Results 121 to 130 of about 10,325 (203)

Identification of miR‐150‐5p in Human Amniotic Membrane Mesenchymal Cell‐Derived Extracellular Vesicles as a Novel Mechanism Driving Cardioprotection

European Journal of Clinical Investigation, Volume 56, Issue 5, May 2026.
Human amniotic membrane mesenchymal stem cells (hAMSCs) provide significant cardioprotection following myocardial ischemia/reperfusion injury. They improve cardiac function and reduce fibrosis by modulating the MIAT/miR‐150‐5p/HOXA4 signalling axis.
Nunzio Alcharani, Laura Tesoro, Javier Díez‐Mata, José Luis Zamorano, Marta Saura, Maite Iglesias, Carlos Zaragoza   +6 more
wiley   +1 more source

Manganese is essential for PlcP metallophosphoesterase activity involved in lipid 2 remodelling in abundant marine heterotrophic bacteria [PDF]

, 2018
In vast areas of the ocean, microbes must adapt to the availability of scarce nutrients, and a key strategy for reducing the cellular phosphorus (P) quota is to remodel membranes by replacing phospholipids with non-P surrogate lipids.
Chen, Yin, Quareshy, Mussa, Scanlan, David J., Wei, Tao, Zhang, Yu-zhong   +4 more
core   +1 more source

Sphingomyelin-induced glucocorticoid receptor alterations lead to impaired presynaptic plasticity in acid sphingomyelinase deficient neurons

Neurobiology of Disease
Acid sphingomyelinase deficiency (ASMD) is a rare disease caused by mutations in the gene encoding ASM, an enzyme that degrades sphingomyelin (SM). In addition to SM accumulation, neuroinflammation and cognitive impairment are pathological hallmarks of ...
Sara Naya-Forcano, Ángel Gaudioso, Beatriz Soto-Huelin, Celia García-Vilela, César Venero, Edward H. Schuchman, José A. Esteban, María Dolores Ledesma   +7 more
doaj   +1 more source

Inhibition of fatty acid amide hydrolase prevents pathology in neurovisceral acid sphingomyelinase deficiency by rescuing defective endocannabinoid signaling

EMBO Molecular Medicine, 2020
Acid sphingomyelinase deficiency (ASMD) leads to cellular accumulation of sphingomyelin (SM), neurodegeneration, and early death. Here, we describe the downregulation of the endocannabinoid (eCB) system in neurons of ASM knockout (ASM‐KO) mice and a ASMD
Adrián Bartoll, Ana Toledano‐Zaragoza, Josefina Casas, Manuel Guzmán, Edward H Schuchman, María Dolores Ledesma   +5 more
doaj   +1 more source

Dysregulated Choline, Methionine, and Aromatic Amino Acid Metabolism in Patients with Wilson Disease: Exploratory Metabolomic Profiling and Implications for Hepatic and Neurologic Phenotypes. [PDF]

, 2019
Wilson disease (WD) is a genetic copper overload condition characterized by hepatic and neuropsychiatric symptoms with a not well-understood pathogenesis.
Czlonkowska, Anna, Kim, Kyoungmi, Litwin, Tomasz, Mazi, Tagreed A, Medici, Valentina, Sarode, Gaurav V, Shibata, Noreene M   +6 more
core   +2 more sources

Factor V G1691A (Leiden) is a major etiological factor in Egyptian Budd-Chiari syndrome patients [PDF]

, 2011
Objective: Budd-Chiari syndrome is a multifactorial disease in which several prothrombotic disorders may predispose patients to the development of thrombosis at this uncommon location (hepatic veins). The aim of this study was to determine the prevalence
Ezzat S. Elsobky, Mohamed A. Sakr, Nejat Akar, Said Yousuf, Sara M. Abdelhakam, Solaf M. Elsayed, Tawhida Y. Abdel Ghaffar, Yonca Eğin   +7 more
core  

Characterization of an influenza virus pseudotyped with Ebolavirus glycoprotein [PDF]

, 2018
We have produced a new Ebola virus pseudotype: E-S-FLU, which can be handled in biosafety level-1/2 containment for laboratory analysis. E-S-FLU is a single cycle influenza virus coated with Ebolavirus glycoprotein, and it encodes enhanced green ...
Annaert, Wim, Rijal, Pramila, Schimanski, Lisa, Tharkeshwar, Arun Kumar, Townsend, Alain, Wright, Edward, Xiao, Julie   +6 more
core   +1 more source

Case Report of Gastrointestinal Bleeding in an Adult with Chronic Visceral Acid Sphingomyelinase Deficiency

Case Reports in Gastrointestinal Medicine, 2019
Introduction. Acid sphingomyelinase deficiency (ASMD, also known as Niemann-Pick Type A and Type B disease) is a rare, inherited metabolic disorder.
David Cassiman, Louis Libbrecht, Wouter Meersseman, Alexander Wilmer   +3 more
doaj   +1 more source

Pb(II) Induces Scramblase Activation and Ceramide-Domain Generation in Red Blood Cells [PDF]

, 2018
The mechanisms of Pb(II) toxicity have been studied in human red blood cells using confocal microscopy, immunolabeling, fluorescence-activated cell sorting and atomic force microscopy. The process follows a sequence of events, starting with calcium entry,
A Bateman, A Iannelli, AB García-Arribas, AB García-Arribas, AB García-Arribas, AK Shettihalli, B Liu, B Verhoven, BM Castro, C Brugnara, C-W Chen, D Bratosin, D Bratosin, D Smrž, DJ López, DS Kempe, E Lang, E Sugawara, EM Bevers, EM Bevers, EM Bevers, EM Bifano, F Basse, F Contreras, F Lang, F Lang, FE Boas, FX Contreras, FX Contreras, G Grynkiewicz, H Ahyayauch, H Andree, HP Monteiro, IC Aguilar-Dorado, IM Posada, J Connor, J Mas-Oliva, J Sot, J Zhao, JG Stout, JH Shin, JS Owen, JV Busto, KL Dreher, L D’Auria, L He, L Sánchez-Magraner, LA Cowart, LR Montes, M Piagnerelli, MB Ruiz-Arguello, P Williamson, P Yuan, PA Lang, PM Henson, Q Zhou, R Bettaiya, R Glaser, R Kolesnick, R Mateo, RA Goyer, S Hartel, S Hechtenberg, S Mandal, S-N Wu, SC Frasch, SK Sahu, T Simons, T Wiedmer, T Yabu, US Gaipl, V Battistini, VA Fadok, VA Fadok, VA Fadok, VG Francis, VG Francis, Y Guri, Y Nishizaki, Y-J Cao, YA Hannun   +80 more
core   +2 more sources

Niemann–Pick Disease versus acid sphingomyelinase deficiency [PDF]

Cell Death & Differentiation, 2001
J Lozano, A Morales, A Cremesti, Z Fuks, J L Tilly, E Schuchman, E Gulbins, R Kolesnick   +7 more
openaire   +1 more source