Results 31 to 40 of about 11,139 (183)

Patient iPSC‐derived astrocytes reveal impaired homeostasis and reactive‐like features in propionic acidemia

The Journal of Pathology, EarlyView.
Abstract Propionic acidemia (PA) is a neurometabolic disorder caused by propionyl‐CoA carboxylase deficiency with frequent neurological involvement, yet cell‐type‐specific mechanisms remain poorly defined. We established human induced pluripotent stem cell (iPSC)‐derived astrocytes (iAs) from patients harboring PCCA or PCCB mutations and investigated ...
Irene González‐Garnacho, Mar Álvarez, Francisco Zafra, Pilar Rodríguez‐Pombo, Lourdes R Desviat, Eva Richard   +5 more
wiley   +1 more source

Acid–Base Status During Venoarterial Extracorporeal Membrane Oxygenator Support in Patients With Cardiogenic Shock

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The prognostic significance of an adverse acid–base milieu despite venoarterial extracorporeal membrane oxygenation support in patients with cardiogenic shock remains poorly defined.
Garima Dahiya, J. Kyle Bohman, Joseph E. Tonna, Dustin B. Hillerson, Katrina J. Augustin, Suraj M. Yalamuri, Kianoush B Kashani, Jacob C. Jentzer   +7 more
doaj   +1 more source

Hemodynamic Effects of Prolonged Apneic Oxygenation in Laryngologic Surgery: A Randomized Controlled Pilot Trial

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Limited data exist on cardiocirculatory responses associated with extended periods of apnea during administration of high‐flow nasal oxygen for laryngologic surgery (apneic oxygenation with HFNO, AO‐HFNO). The possibility of hemodynamic compromise in the settings of acute hypercapnia, respiratory acidosis, hyperoxia, and IV ...
Vladimir Nekhendzy, Hendrikus J. Lemmens, Amit R. Saxena, Brita M. Mittal, Edward J. Damrose, C. Kwang Sung, Raffick Bowen   +6 more
wiley   +1 more source

Severe Metabolic Acidosis in Intensive Care: Implications for Acute Kidney Injury, Bicarbonate, and Renal Replacement Therapy

Kidney and Dialysis
Severe metabolic acidosis is a frequent finding in the intensive care unit (ICU) and a critical marker of clinical severity and organ dysfunction, closely linked to acute kidney injury (AKI) due to shared physiological mechanisms and the loss of the ...
Carlos Rebolledo-Maldonado, Juan Solano-Ropero, Elber Osorio-Rodríguez, Aleyda Parra-Castillo, Carlos Beltran-Sánchez, Neil Martínez-Fontalvo, Diego González-Betancur, Dairo Rodelo-Barrios, Manuel Cueto-Chaparro, José Correa-Guerrero, Alberto Polo-Barranco, Carmelo Dueñas-Castell   +11 more
doaj   +1 more source

Added Value of Estimated Fetal Weight Growth Velocity to Doppler Evaluation for the Prediction of Perinatal Outcomes Among Foetuses With EFW < 10th Centile at Term: A Retrospective Cohort Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To evaluate whether estimated fetal weight (EFW) growth velocity (GV), assessed using interval‐specific standards, provides additional prediction beyond standard criteria for identifying adverse outcomes in term foetuses with EFW < 10th centile. Design Retrospective cohort study. Setting Tertiary perinatal centre. Population A cohort
Eva Meler, Cesar Gil‐Armas, Marina Moliner, Edurne Mazarico, Clara Montañés, Anna Peguero, Francesc Figueras   +6 more
wiley   +1 more source

Secondary Hemophagocytosis in Propionic Acidemia [PDF]

Iranian Journal of Pediatrics, 2015
Dear Editor, Propionic acidemia is one of the intoxication type organic acidemias, which often present in the neonatal period with lethargy, feeding difficulties, hypotonia, vomiting and coma if not identified and treated appropriately. Patients with propionic acidemia can decompensate during periods of increased metabolic demand (1, 2 ...
Kasapkara, Cigdem Seher, TÜMER, LEYLA, EZGÜ, FATİH SÜHEYL, Hasanoglu, Alev, Karatas, Mustafa, Demir, Remezan, Ozbek, Mehmet Nuri, Ozmen, Banu Oflaz, Kangin, Murat   +8 more
openaire   +4 more sources

Deep brain stimulation outcomes and management of childhood‐onset dystonia and associated hyperkinetic movements disorders

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To examine longitudinal changes in self‐selected goals and dystonia severity over 1 year, 2 years, and 5 years after deep brain stimulation (DBS) in children and young people (CYP) with dystonia and other hyperkinetic movement disorders, using CYP and caregiver reports.
Sinead Barkey, Laura Ainaga, Eva Maria Navarrete Muñoz, Verity McClelland, Keyoumars Ashkan, Richard Selway, Harutomo Hasegawa, Daniel E Lumsden, Jean‐Pierre Lin, Hortensia Gimeno   +9 more
wiley   +1 more source

Predicting Intrapartum Acidemia: A Review of Approaches Based on Fetal Heart Rate

Bioengineering
Fetal acidemia, caused by impaired gas exchange between the fetus and the mother, is a leading cause of stillbirth and neurologic complications. Early prediction is therefore essential to guide timely clinical intervention.
Gabriele Varisco, Giulio Steyde, Elisabetta Peri, Iris Hoogendoorn, Maria G. Signorini, Judith O. E. H. van Laar, Massimo Mischi, Marieke B. van der Hout-van der Jagt   +7 more
doaj   +1 more source

Anaesthetic management of a horse with acute kidney injury

Equine Veterinary Education, EarlyView.
Summary Anaesthetic management of animals with acute kidney injuries (AKI) is complex and poses considerable risk. There are no publications describing management of anaesthetised horses with AKI. Perioperative and anaesthetic care of a Thoroughbred filly presented with traumatic injuries and subsequent AKI is described.
C. T. Quinn, K. J. Hughes, A. N. Walton
wiley   +1 more source

Clinical use of sodium bicarbonate in small animals: indications, electrolyte changes and survival outcome

Journal of Small Animal Practice, EarlyView.
Objectives The objective of the study was to describe the use of sodium bicarbonate in dogs and cats. Materials and Methods Retrospective descriptive study of animals administered sodium bicarbonate from 2019 to 2023 in a university teaching hospital.
L. Hoover, M. A. Oyama, E. L. Reineke
wiley   +1 more source