Results 111 to 120 of about 415,146 (302)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Dissolution kinetics of coal and limestone samples from Kogi state, Nigeria

African Scientific Reports
This work is concerned with the dissolution behaviour and kinetics of Okobo coal and Obajana limestone from Kogi State, Nigeria, within acidic, basic, and neutral media. This was achieved using hydrochloric acid and sodium hydroxide with distilled water,
Anthony Ugbedeojo Atumeyi, Adams Udoji Itodo, Rufus Sha'Ato, Raymond Ahulle Wuana   +3 more
doaj   +1 more source

Sulfuric acid leaching of mechanically activated manganese carbonate ore

Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2010
Acidic leaching of mechanically activated manganese ore from Denizli – Tavas was investigated. The ore was activated mechanically in a planetary mill and the amorphisation in manganese structure was analyzed with X-ray diffraction.
Kenan Yıldız
doaj   +1 more source

Electrooxidation of a cobalt based steel in LiOH: a non-noble metal based electro-catalyst suitable for durable water-splitting in an acidic milieu

, 2017
The use of proton exchange membrane (PEM) electrolyzers is the method of choice for the conversion of solar energy when frequently occurring changes of the current load are an issue. However, this technique requires electrolytes with low pH.
Daum, Diemo, Hana, Weijia, Krupp, Ulrich, Küpper, Karsten, Müller-Buschbaum, Klaus, Schmidt, Mercedes, Schäfer, Helmut, Stangl, Johannes, Steinhart, Martin, Wollschläger, Joachim   +9 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Oligosaccharide Generation in Acidic Sugar Media

Journal of AOAC INTERNATIONAL, 1993
Abstract Oligosaccharides were shown to be present in beet medium invert sugar, but the origin of these molecules has remained obscure. The present study reveals that oligosaccharides are not a contaminant of purified beet sucrose. They appear during sucrose hydrolysis but are not specific to inversion.
openaire   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Conditions and reactions defining dye bacteriostasis [PDF]

, 1926
The continued study of bacterial cells from the point of view which assumes that they behave as conjugated proteins (Stearn and Stearn, 1924a and b) has led to an intensive study of the action of both basic and acid dyes in their bacteriostatic and ...
Stearn, Allen E., Stearn, Esther Wagner
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source