Results 51 to 60 of about 196,806 (297)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

2-(o-Hydroxyphenyl)Benzimidazole as a New Corrosion Inhibitor for mild Steel in Hydrochloric Acid Solution

International Journal of Electrochemical Science, 2012
In this study, 2-(o-Hydroxyphenyl)benzimidazole (HPB) was synthesized, characterized and tested as a new corrosion inhibitor for mild steel in 1M HCl solution.
Y. Abboud, B. Hammouti, A. Abourriche, B. Ihssane, A. Bennamara, M. Charrouf, S.S. Al-Deyab   +6 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Air Oxidation of 2-Aryl-1-tetralones in Basic, Neutral, and Acidic Media:  An Unprecedented Oxidative Aryl Migration to 2-Aryloxy-1-naphthols under Acidic Condition

, 2016
Air Oxidation of 2-Aryl-1-tetralones in Basic, Neutral, and Acidic Media:  An Unprecedented Oxidative Aryl Migration to 2-Aryloxy-1-naphthols under Acidic ...
Tsutomu Ishikawa (1699012), Masayuki Murota (3047184), Toshiko Watanabe (2694472), Takaaki Yoneda (3047187), Kentaro Yamaguchi (1415581), Keiko Hino (3047190)   +5 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The time course of the transcriptomic response of Sinorhizobium meliloti 1021 following a shift to acidic pH

, 2009
Hellweg C, Pühler A, Weidner S. The time course of the transcriptomic response of Sinorhizobium meliloti 1021 following a shift to acidic pH. BMC MICROBIOLOGY.
Hellweg Christoph, Hellweg, Christoph, Pühler Alfred, Pühler, Alfred ; https://orcid.org/, Christoph Hellweg, Alfred Pühler, Stefan Weidner, Weidner, Stefan, Weidner Stefan   +8 more
core   +1 more source

Nanostructured Electrocatalysts for CO2 Conversion in Acidic Electrolytes

Small Structures
Electrochemical CO2 reduction in acidic media offers an appealing route to overcome the issues related to carbonates precipitation in neutral or basic electrolytes.
Shangfeng Chen, Hermenegildo García, Josep Albero   +2 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source