Results 101 to 110 of about 242,934 (307)

Region‐Specific Profiling of the Gut Microbiome and Metabolite Landscape in Response to Dietary Intervention Using Electronics‐Free Ingestible Smart Sampling Capsules

Advanced Materials Technologies, EarlyView.
Region‐specific profiling of the gut microbiome is achieved non‐invasively using electronics‐free ingestible sampling capsules that activate at defined intestinal sites through stimuli‐responsive coatings. Deployed in a porcine dietary intervention model, the capsules resolve spatially distinct, fiber‐driven shifts in microbial composition and short ...
Devendra Sarnaik, Caitlyn Sullivan, Akshay Krishnakumar, Fangxin Chen, Anna Clapp Organski, Wayne W. Campbell, Jay S. Johnson, Tzu‐Wen L. Cross, Rahim Rahimi   +8 more
wiley   +1 more source

Investigation on life cycle assessment of lead and zinc production [PDF]

International Journal of Mining and Geo-Engineering, 2015
Lead and zinc production is one of the main predisposing factors of excessive greenhouse gases emissions, air pollution and water consumption. In this paper, the environmental problems of lead and zinc production in Calcimin plant are expressed and life ...
Sabere Nazari, Mehdi Gharabaghi
doaj  

Extrusion‐Based Bioprinting of Living Bioinks for Tissue and Organ Engineering

Advanced Materials Technologies, EarlyView.
Extrusion‐based bioprinting is presented as the most versatile route for fabricating living, heterogeneous tissues. Its ability to combine diverse bioinks, support matrices, and advanced printhead geometries transforms familiar constraints into powerful biofabrication opportunities.
Eric Silberman, Ester Sapir Baruch, Roni Cohen, Assaf Shapira, Tal Dvir   +4 more
wiley   +1 more source

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source

Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo

eLife, 2019
Lysosomal acidification is a key feature of healthy cells. Inability to maintain lysosomal acidic pH is associated with aging and neurodegenerative diseases.
K. F. Yambire, Christine M Rostosky, Takashi Watanabe, D. Pacheu-Grau, S. Torres-Odio, Á. Sánchez-Guerrero, Ola Senderovich, E. Meyron-Holtz, Ira Milosevic, J. Frahm, A. West, Nuno Raimundo   +11 more
semanticscholar   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Efeito da acidificação, fermentação e adição de cálcio na qualidade de couve-flor (Brassica oleraceae L.) processada pelo calor Effect of acidification, fermentation and addition of calcium on the quality of canned cauliflower (Brassica oleraceae L.)

Scientia Agricola, 1993
O presente trabalho foi desenvolvido com o objetivo de fornecer informações, não encontradas na literatura, sobre o efeito da acidificação (cinco ácidos orgânicos), fermentação e adição de cálcio na qualidade de couve-flor (cultivar Shiromaru III ...
J.N. Nogueira, P.R. Cantarelli, C.R. Gallo, I.A.M. Moreno, F.C.A.V. Matsuura   +4 more
doaj   +1 more source

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

Multimodal Imaging of Hypoxia, Metabolism and pH in Feline Sarcoma Using Hyperpolarized ¹³C MRI and PET. [PDF]

Adv Sci (Weinh)
This work presents a clinically deployable simultaneous PET/MRI workflow which integrates hyperpolarized 13C imaging of metabolism and extracellular pH with [18F]FMISO PET to characterize hypoxia, acidosis, and metabolic reprogramming in feline sarcoma.
Grashei M, Groll T, Kahl S, Baer S, Bliemsrieder E, van Heijster FHA, Wendlinger A, Wodtke P, Cabello J, Notohamiprodjo S, Lohrmann C, Schwaiger M, Weber WA, Steiger K, Meyer-Lindenberg A, Hirschberger J, Baumgartner C, Schilling F.   +17 more
europepmc   +2 more sources

Effects of Ocean Acidification on Marine Photosynthetic Organisms Under the Concurrent Influences of Warming, UV Radiation, and Deoxygenation

Frontiers in Marine Science, 2019
The oceans take up over 1 million tons of anthropogenic CO2 per hour, increasing dissolved pCO2 and decreasing seawater pH in a process called ocean acidification.
K. Gao, J. Beardall, D. Häder, J. Hall-Spencer, Guang Gao, D. Hutchins   +5 more
semanticscholar   +1 more source