Results 191 to 200 of about 242,934 (307)

The ocean: a key Earth system regulator with boundaries. [PDF]

Natl Sci Rev
Mathesius S, Kaiser J, Ödalen M, Rockström J, Sakschewski B, Caesar L.   +5 more
europepmc   +1 more source

FBP1‐Mediated Compartmentalization of Glycolytic Enzyme Complexes Suppresses PKM2 Function to Ameliorate MASLD Progression

Advanced Science, EarlyView.
In normal hepatocytes, FBP1 forms compartmentalized complexes with PKM2, ENO1, and LDHA independent of its catalytic activity, inhibiting PKM2 activity and restricting excessive glycolysis. During MASLD progression, FBP1 downregulation markedly reduces the abundance of these complexes and releases the “hijacked” glycolytic enzymes, leading to PKM2 ...
Busong Wang, Yiping Tang, Na Li, Xuening Dai, Jing Wu, Bin Xue, Yuxin Chen, Jingzi Zhang, Lingdong Kong, Chaojun Li, Lei Fang   +10 more
wiley   +1 more source

Biosensors reveal distinct cytosolic pH and redox dynamics across seedlings in response to danger signals and pathogen infection. [PDF]

J Exp Bot
Mor E, Ramesh K, Bandaru H, Robatzek S.
europepmc   +1 more source

In Situ Generation of Gel Foam via Heat‐Accelerated Calcium Ion Release From Nano‐CaCO3 for Lithium‐Ion Battery Fire Suppression and Prevention

Advanced Science, EarlyView.
We present a heat‐accelerated in situ crosslinking strategy to create an alginate gel foam for lithium‐ion battery fire suppression. At ambient temperature, the formulation maintains low viscosity for easy foam generation. After exposure to fire, δ‐gluconolactone hydrolysis accelerates, enabling rapid Ca2+ release from CaCO3 and rapid ionic ...
Xiaoyang Yu, Cuiping Li, Mingjun Xu, Man Pun Wan   +3 more
wiley   +1 more source

Wood Carbon Sponge/SiO2 Aerogel Composites with Anisotropic Broadband Microwave Absorption, Elastic Resilience, and Thermal Insulation

Advanced Science, EarlyView.
Anisotropic wood carbon sponge/SiO2 aerogel composites are constructed, revealing a robust direction‐dependent permittivity ordering (tangential > radial > axial). The radial direction delivers an ultra‐broadband effective absorption bandwidth of 11.6 GHz at only 4.95 mm, while the tangential direction offers superior compressibility and thermal ...
Shuo Sun, Zhimeng Zhao, Weikai Zhan, Yonggang Jiang, Fengqi Liu, Yijie Hu, Junzong Feng, Jian Feng   +7 more
wiley   +1 more source

Recent and Promising Strategies for Robust, Sustainable, and Cost-Friendly Production of Yogurt With Superior Quality. [PDF]

Compr Rev Food Sci Food Saf
Zhao S, Tadesse BT, Solem C.
europepmc   +1 more source

TROP2‐Targeting Chimeras (TRTACs) for Tumor Cell‐Selective Membrane Protein Degradation and Enhanced Drug Delivery

Advanced Science, EarlyView.
TROP2 is identified as a novel tumor‐selective lysosomal‐targeting receptor with established clinical relevance. TROP2‐targeting chimeras (TRTACs) are developed by genetically fusing a TROP2‐binding nanobody to nanobodies against specific target proteins.
Luping Chen, Xinying Fu, Wenqian Dong, Xiaobei Deng, Simin Chen, Fujun Wang, Jian Zhao, Shiqun Shao, Liqiang Fan, Jingyu Zhang, Lixin Zhang   +10 more
wiley   +1 more source

African swine fever virus impairs porcine alveolar macrophages bactericidal function by disrupting lysosomal acidification and cathepsin activity. [PDF]

PLoS Pathog
Xu Z, Shi F, Xiang Z, Guo R, Wen Z, Qu Y, Li Q, Zhou Q, Gao P, Zhang Y, Ge X, Han J, Guo X, Zhou L, Yang H.   +14 more
europepmc   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Strain-Specific Antimicrobial Mechanisms of Lactic Acid Bacteria Against <i>Listeria monocytogenes</i> Scott A Under Nutrient-Rich and Carbohydrate-Limited Conditions. [PDF]

Microorganisms
Didos S, Tsotsouli K, Saitis O, Koutsoumanis K, Argiriou A.   +4 more
europepmc   +1 more source