Results 151 to 160 of about 202,074 (311)
, 1984 One of the most important aspects of the soil acidity research programme is the accurate analysis of soil and plant materials. A soil acidity problem cannot be simply diagnosed with one test.
Wilson, I R
core +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Why Targeting Tumor Acidity Fails: Translational Barriers and Emerging Solutions. [PDF]
Int J Mol SciKim KH, Yoo BC.
europepmc +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Erosive Potential of Commercially Available Cannabis Beverages. [PDF]
Clin Exp Dent ResBoonsuth B +11 more
europepmc +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
, 2014 台灣冬天旱季生產的葡萄不但糖度高，香氣濃，病害少，具有許多超越夏季葡萄的優點，同時冬季低溫比夏季更適合葡萄酒的釀造。近年來雖有釀酒葡萄產期調整到冬季之議，但由於冬季葡萄酸度過高，且經多年之調查仍不明其原因，因此遲遲不能推展。 本研究針對上述冬季葡萄酸度過高的問題，比較分析冬季與夏季葡萄，單粒果實內酒石酸與蘋果酸變化的差異，探討冬季葡萄酸度偏高的生理原因。 酒石酸與蘋果酸形成與消失的曲線，在冬夏兩季並無顯著不同，差異僅在夏季葡萄蘋果酸含量下降幅度較大，成熟末期幾乎可能完成被分解 ...
李國權 +3 more
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