Results 41 to 50 of about 104,185 (298)

Adjunctive interferon-γ immunotherapy for the treatment of HIV-associated cryptococcal meningitis: a randomized controlled trial.

, 2012
BACKGROUND: Interferon-gamma (IFNγ) is of key importance in the immune response to Cryptococcus neoformans. Mortality related to cryptococcal meningitis remains high, and novel treatment strategies are needed.
Bekker, Linda-Gail, Bicanic, Tihana, Harrison, Thomas S, Jarvis, Joseph N, Meintjes, Graeme, Rebe, Kevin, Schutz, Charlotte, Williams, Anthony, Williams, Gertrude Ntombomzi, Wood, Robin   +9 more
core   +1 more source

Successful Extracorporeal Life Support for Life-threatening Hypercapnia with Bronchiolitis Obliterans after Allogeneic Hematopoietic Stem Cell Transplantation [PDF]

, 2011
Bronchiolitis obliterans (BO) is a disease with a poor prognosis, and a key factor that limits long-term survival after allogeneic hematopoietic stem cell transplantation (HSCT).
Ichiba, Shingo, Kanehiro, Arihiko, Maeda, Yoshinobu, Miyahara, Nobuaki, Murakami, Toshi, Nagano, Osamu, Ochi, Nobuaki, Tanimoto, Mitsune, Tanimoto, Yasushi, Terado, Michihisa, Ujike, Yoshihito, Waseda, Koichi   +11 more
core   +1 more source

Throat and rectal swabs may have an important role in MRSA screening of critically ill patients.

, 2008
OBJECTIVE: Methicillin-resistant Staphylococcus aureus (MRSA) is a major problem in intensive care units (ICU). International guidelines recommend screening patients for MRSA on admission, although consensus on sites required for optimum detection has ...
Batra, Rahul, Edgeworth, Jonathan, Eziefula, Alice C, Wyncoll, Duncan   +3 more
core   +1 more source

Associations between Dietary Acid Load and Biomarkers of Inflammation and Hyperglycemia in Breast Cancer Survivors. [PDF]

, 2019
Metabolic acidosis can lead to inflammation, tissue damage, and cancer metastasis. Dietary acid load contributes to metabolic acidosis if endogenous acid-base balance is not properly regulated.
Hollenbach, Kathryn, Lemus, Hector, Pierce, John P, Seaver, Phoebe, Wang, Emily, Wu, Tianying   +5 more
core   +2 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Inhalational sevoflurane in severe bronchial obstruction unresponsive to multipharmacologic therapy: a case report [v1; ref status: indexed, http://f1000r.es/Tg4qxg]

F1000Research, 2012
Introduction: Bronchial asthma with respiratory failure is a challenge for the intensivist as mechanical ventilation is often difficult due to bronchoconstriction and air-trapping.
Thomas Weber, Christian Schiebenpflug, Engelbert Deusch   +2 more
doaj   +1 more source

The Cerebellar Fastigial Nucleus Contributes to CO\u3csub\u3e2\u3c/sub\u3e-H\u3csup\u3e+\u3c/sup\u3e Ventilatory Sensitivity in Awake Goats [PDF]

, 2007
The purpose of this study was to test the hypothesis that an intact cerebellar fastigial nucleus (CFN) is an important determinant of CO2-H+ sensitivity during wakefulness.
Bonis, Joshua M., Davis, S., Forster, Hubert V., Krause, Katie L., Martino, P. F., Opansky, C., Pan, Lawrence, Qian, B.   +7 more
core   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

New insights in gill/buccal rhythm spiking activity and CO2 sensitivity in pre- and post-metamorphic tadpoles (Pelophylax ridibundus)

, 2013
Central CO2chemosensitivity is crucial for all air-breathing vertebrates and raises the question of itsrole in ventilatory rhythmogenesis. In this study, neurograms of ventilatory motor outputs recorded infacial nerve of premetamorphic and ...
Fiamma, Marie-Noëlle, Horcholle-Bossavit, Ginette, Quenet, Brigitte, Rivals, Isabelle, Similowski, Thomas, Straus, Christian   +5 more
core   +3 more sources

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source