Anaemia and blood transfusion in African children presenting to hospital with severe febrile illness [PDF]
, 2015 BACKGROUND: Severe anaemia in children is a leading cause of hospital admission and a major cause of mortality in sub-Saharan Africa, yet there are limited published data on blood transfusion in this vulnerable group.
Akech, SO +13 more
core +1 more source
Advanced Science, EarlyView.This study designs a targeted nanocomposite (ct@HMCF‐Dex) that responds to acidic infection microenvironments, releasing components which amplify oxidative stress. It disrupts bacterial redox balance, chelates metals to sustain lipid peroxidation, and synergistically induces cuproptosis/ferroptosis‐like death.
Zehui Xiao +6 more
wiley +1 more source
Case Reports in Anesthesiology, 2016 A 53-year-old man with chronic renal tubular acidosis and subclinical hypothyroidism underwent lower leg amputation surgery under general anesthesia.
Hiroe Yoshioka +4 more
doaj +1 more source
Hemodialysis in COVID-19 Patients: Yes or No? A Commentary
Oman Medical Journal, 2020 COVID-19 is responsible for lower respiratory infections and can cause acute respiratory distress syndrome (ARDS). Studies have shown that patients in a critical condition can quickly develop ARDS, shock, metabolic acidosis, impaired blood coagulation ...
Amin Hosseini, Fatemeh Bahramnezhad
doaj +1 more source
Potentially Diagnostic Electron Paramagnetic Resonance Spectra Elucidate the Underlying Mechanism of Mitochondrial Dysfunction in the Deoxyguanosine Kinase Deficient Rat Model of a Genetic Mitochondrial DNA Depletion Syndrome [PDF]
, 2016 A novel rat model for a well-characterized human mitochondrial disease, mitochondrial DNA depletion syndrome with associated deoxyguanosine kinase (DGUOK) deficiency, is described.
Bennett, Brian +8 more
core +2 more sources
m.10010T>C Mitochondrial Disease: A Case Report With Hypoparathyroidism and Review of the Literature
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Mitochondria are essential intracellular organelles that play a critical role in cellular metabolism, including the regulation of intracellular calcium signaling. Advances in genomic sequencing have facilitated the identification of rare pathogenic mitochondrial DNA (mtDNA) genetic variants in patients with unexplained endocrine disorders.
Jacob Mohr +5 more
wiley +1 more source
OXYGENATION BY USING 10 LPM BAG AND MASK IMPROVES RESPIRATORY ACIDOSIS
Jurnal Ners, 2017 Introduction: ALO (Acute Lung Oedema) is the most common and remarkably life threatening medical emergency. It is not unusual that clients come to the hospital in critical condition.
Sunarko Setyawan +3 more
doaj +1 more source
Nanoantidote for repression of acidosis pH promoting COVID‐19 infection
View, 2022 Acidosis, such as respiratory acidosis and metabolic acidosis, can be induced by coronavirus disease 2019 (COVID‐19) infection and is associated with increased mortality in critically ill COVID‐19 patients.
Qidong Liu +6 more
doaj +1 more source
Diagnosing Severe Falciparum Malaria in Parasitaemic African Children: A Prospective Evaluation of Plasma PfHRP2 Measurement. [PDF]
, 2012 In African children, distinguishing severe falciparum malaria from other severe febrile illnesses with coincidental Plasmodium falciparum parasitaemia is a major challenge. P. falciparum histidine-rich protein 2 (PfHRP2) is released by mature sequestered
Amos, Ben +23 more
core +5 more sources
Expanding the Phenotype of TUFM‐Related Combined Oxidative Phosphorylation Deficiency 4
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Combined oxidative phosphorylation deficiency 4 (COXPD4) is a rare mitochondrial condition caused by biallelic deleterious variants in the nuclear‐encoded gene TUFM. To date, most individuals with COXPD4 have presented with encephalopathy, hypotonia, and abnormal brain imaging. Many of the reported individuals died in infancy. We aim to expand
Noémie Villeneuve‐Cloutier +2 more
wiley +1 more source