Results 271 to 280 of about 233,323 (358)

Tumor-derived sphingosine-1-phosphate shapes angiogenesis in the acidic microenvironment of osteosarcoma via paracrine and autocrine signaling. [PDF]

Front Cell Dev Biol
Avnet S, Bozzini N, Nguyen PN, Lipreri MV, Perut F, Baldini N, Cortini M.   +6 more
europepmc   +1 more source

CD93—An emerging vascular target in cancer therapy

British Journal of Pharmacology, EarlyView.
Abstract CD93 is a single‐pass transmembrane glycoprotein that belongs to the C‐type lectin domain group XIV family of proteins. Although it is known to be expressed in other cell types, namely, in some subsets of immune cells, CD93 is primarily expressed on endothelial cells, where it acts as a crucial regulator of angiogenesis.
Beatriz de Alves Pereira, Stefano Barbera, Roberta Lugano, Anna Dimberg   +3 more
wiley   +1 more source

Metformin Toxicity Unmasked by Obstructive Uropathy: A Case of Metformin Associated Lactic Acidosis and Euglycemic Diabetic Ketoacidosis. [PDF]

Discoveries (Craiova)
Khan RS, Patla A, Ayyazuddin M, Michaeil G, Shah R, Rajaram S.   +5 more
europepmc   +1 more source

Periodontitis‐Associated Circulating EVs Promote Colorectal Cancer Progression via Carnosine‐Mediated Acidosis Adaptation

Cell Proliferation, EarlyView.
This study identifies a link between periodontitis and CRC progression mediated by carnosine‐enriched circulating EVs. These EVs target the intestine and elevate tumour cell intracellular pH (pHi), which rescues lysosomal function. This process drives a transition from dysfunctional lysosomes to functional ones, promoting a high malignancy phenotype in
Ruoyi Wu, Zihan Cai, Hualing Sun, Haikun Yu, Bicheng Zhang, Chi Zhang, Yi Fan, Xiaoxuan Zhu, Yueqi Ni, Yu Cui, Kaixin Wang, Zhe Li, Xinyi Zhou, Qing He, Yanru Wu, Yufeng Zhang   +15 more
wiley   +1 more source

The anion gap: basic chemistry, powerful clinical implications. [PDF]

Singapore Med J
Fong JMN, Tang GXJ, See KC.
europepmc   +1 more source

Mediator bias and methodological limitations in the evaluation of physiological CTG interpretation

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Boujenah Jérémy
wiley   +1 more source

Integrated Engineering of CAR‐T Cells for Solid Tumours

Cell Proliferation, EarlyView.
Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang, Tan Li, Ping He, Zhijie Zhao, Shenglong Li, Liming Wang   +5 more
wiley   +1 more source

Survival after severe aluminum phosphide poisoning complicated by concurrent insulin overdose: A case report. [PDF]

Toxicol Rep
Rasouli M, Goli R, Mohammadi N, Karimi N.   +3 more
europepmc   +1 more source

Early neurodevelopmental outcome in newborns with mild hypoxic‐ischaemic encephalopathy

Developmental Medicine &Child Neurology, EarlyView.
Aim To describe the natural history of newborn children with mild hypoxic‐ischaemic encephalopathy in the first year of life. Method This was a multicentre, prospective observational study involving five neonatal intensive care units in an Italian region using both structured clinical and neurophysiological assessments according to the Italian Society ...
Domenico M. Romeo, Chiara Arpaia, Angelo Di Malta, Elisa Pede, Grazia Maria Cicala, Daniela Ricci, Francesca Serrao, Eugenio Mercuri, Claudia Brogna, Mild Encephalopathy Regional Network*, Giovanni Vento, Chiara Cafforio, Eleonora Scapillati, Roberta Arena, Francesca Gallini, Vita Augusta, Andrea Guzzetta   +16 more
wiley   +1 more source