Results 31 to 40 of about 2,829,556 (263)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Replacement of dietary saturated fatty acids by trans fatty acids lowers serum HDL cholesterol and impairs endothelial function in healthy men and women [PDF]

, 2001
We tested whether trans fatty acids and saturated fatty acids had different effects on flow-mediated vasodilation (FMD), a risk marker of coronary heart disease (CHD). Consumption of trans fatty acids is related to increased risk of CHD, probably through
Roos, N.M., de, Katan, M.B., Bots, M.L.
core  

Inverse Association between trans Isomeric and Long-Chain Polyunsaturated Fatty Acids in Pregnant Women and Their Newborns: Data from Three European Countries [PDF]

, 2011
Background: trans unsaturated fatty acids are thought to interfere with essential fatty acid metabolism. To extend our knowledge of this phenomenon, we investigated the relationship between trans isomeric and long-chain polyunsaturated fatty acids ...
Krauss-Etschmann, S., É. Szabó, Marosvolgyi, Tamas, Campoy, C., T. Marosvölgyi, Decsi, Tamás, Marosvölgyi, T., C. Campoy, B. Koletzko, M. Escolano, Campoy, Cristina, Cruz, M., Szabó, É., Krauss-Etschmann, Susanne, S. Krauss-Etschmann, M. Cruz, Szabo, Eva, Escolano, M., Marchal, G., T. Decsi, Koletzko, Berthold, H. Demmelmair, Demmelmair, Hans, G. Marchal   +23 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Towards improved anticancer properties of the G-quadruplex-forming T40231 aptamer through increased flexibility of nucleoside residues

Scientific Reports
In this article, the T40231 aptamer, an anticancer agent, originally known for its ability to inhibit STAT3, was altered with UNAs to enhance its flexibility in the loops or G-tetrads.
Weronika Kotkowiak, Natalia Bartyś, Anna Pasternak   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Quest for space: Tenacity of DNA, Protein, and Lipid macromolecules in intracellular crowded environment

Biomolecular Concepts
The biochemical processes in the cellular milieu involving biomacromolecular interaction usually occur in crowded and heterogeneous environments, impacting their structure, stability, and reactivity.
Phogat Priyanka, Bansal Aparna, Nain Nishu, Khan Shoaib, Saso Luciano, Kukreti Shrikant   +5 more
doaj   +1 more source

Commercial varieties of European plums grown in Hungary, a comparison of promising foreign varieties with the widely grown traditional ones

International Journal of Horticultural Science, 2012
Observations and investigations performed in laboratory at several growing sites over a period of many years are summarised on established plum varieties as well as on new promising ones concerning their marketing value.
Sz. Kovács, Á. Molnár, Gy. Szenci, M. Tóth   +3 more
doaj   +1 more source

Deciphering the tRNA-derived small RNAs: origin, development, and future

Cell Death and Disease, 2021
Transfer RNA (tRNA)-derived small RNAs (tsRNAs), a novel category of small noncoding RNAs, are enzymatically cleaved from tRNAs. Previous reports have shed some light on the roles of tsRNAs in the development of human diseases.
Bowen Liu, Jinling Cao, Xiangyun Wang, Chunlei Guo, Yunxia Liu, Tianjiao Wang   +5 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source