Results 41 to 50 of about 2,829,556 (263)

Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria [PDF]

, 2007
Background. Mycolic acids are a complex mixture of branched, long-chain fatty acids, representing key components of the highly hydrophobic mycobacterial cell wall.
Robert C Reynolds, Coxon, Geoffrey D., Dover, Lynn, Geoffrey D Coxon, Besra, Gurdyal; id_orcid, Besra, Gurdyal S., Besra, Gurdyal, Dover, Lynn G., Reynolds, Robert C., Laurent Kremer, Trivelli, X, Trivelli, Xavier, James C Sacchettini, Sacchettini, JC, Anuradha Alahari, Lynn G Dover, Kremer, Laurent, Kremer, L, Guérardel, Yann, Dover, Lynn G, Coxon, Geoffrey D, Coxon, GD, Gurdyal S Besra, Sacchettini, James C., Reynolds, Robert, Yann Guérardel, Reynolds, Robert C, Reynolds, RC, Coxon, Geoffrey, Gu��rardel, Yann, Alahari, Anuradha, Sacchettini, James C, Gu rardel, Y, Alahari, A, Besra, Gurdyal S, Xavier Trivelli, El-Shemy, Hany, Sacchettini, James   +37 more
core   +1 more source

Self-association of Coralyne: An ordered thermal destacking

Results in Chemistry, 2020
Understanding DNA-ligand interactions is a prerequisite, for designing sequence/structure specific ligands. Generally, stabilization/destabilization of DNA structures as a function of ligand is studied using UV-thermal melting, and the data is usually ...
Shikha Kaushik, Mahima Kaushik, Ritu Barthwal, Shrikant Kukreti   +3 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Exploring potential of i-motif DNA formed in the promoter region of GRIN1 gene for nanotechnological applications

Results in Chemistry, 2020
The tandem repeat stretches of cytosine residues fold to construct intercalated motif (i-motif) structures over an acidic pH range. Several advancements have been made to understand the biological role of i-motif DNA.
Swati Chaudhary, Mahima Kaushik, Saami Ahmed, Shrikant Kukreti   +3 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Anacardic Acids and Ferric Ion Chelation [PDF]

, 2007
6-Pentadeca(e)nylsalicylic acids isolated from the cashew Anacardium occidentale L. (Anacardiaceae), commonly known as anacardic acids, inhibited the linoleic acid peroxidation catalyzed by soybean lipoxygenase-1 (EC 1.13.11.12, type 1) competitively ...
Hayashi, Akio, Tsujimoto, Kazuo, Joung Ha, Tae, Kubo, Isao   +3 more
core  

Amino acids and central fatigue

, 2001
There is an increasing interest in the mechanisms behind central fatigue, particularly in relation to changes in brain monoamine metabolism and the influence of specific amino acids on fatigue.
Blomstrand, Eva,, Blomstrand, E
core   +1 more source

Agrobiological, economical, and technological characteristics of the Ribier table grape variety depending on the different vine loads with fertile buds [PDF]

Agroznanje
The study of the impact of different vine loads on the agrobiological, economical, and technological characteristics of the Ribier variety was carried out in 2020 and 2021 with the aim of determining the optimal load for this variety.
Popović Tatjana, Raičević Danijela, Pajović-Šćepanović Radmila, Matijašević Saša   +3 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

The inhibition of T-lymphocyte proliferation by fatty acids is via an eicosanoid-independent mechanism

, 1992
Eicosanoids, in particular prostaglandin E2 (PGE2), are potent inhibitors of a number of immune responses, including lymphocyte proliferation. We have previously shown that fatty acids, especially polyunsaturated fatty acids (PUFA), inhibit mitogen ...
Calder, P.C., Newsholme, E.A., Bevan, S.J.   +2 more
core   +1 more source