Results 51 to 60 of about 155,970 (361)

Tackling Acinetobacter baumannii

Journal of Clinical Medicine, 2023
Globally, multidrug-resistant (MDR) bacteria represent a menace to public health [...]
Guido Granata, Fabrizio Taglietti, Nicola Petrosillo   +2 more
openaire   +2 more sources

Prevalence and antibiotic resistance patterns of nosocomial urinary tract infections in ICU patients at Shahid Beheshti hospital, Kashan, Iran (2020–2021) [PDF]

Basic and Clinical Biochemistry and Nutrition
Background: Nosocomial urinary tract infections (UTIs) are a significant cause of morbidity and mortality in intensive care units (ICUs), particularly due to the increasing prevalence of multidrug-resistant (MDR) pathogens.
Mohanna Pourjozi, Mahdi Imani, Hamed Pahlevani, Habibollah Rahimi, Maedeh Najafizadeh   +4 more
doaj   +1 more source

Biology of Acinetobacter baumannii: Pathogenesis, Antibiotic Resistance Mechanisms, and Prospective Treatment Options

Frontiers in Cellular and Infection Microbiology, 2017
Acinetobacter baumannii is undoubtedly one of the most successful pathogens responsible for hospital-acquired nosocomial infections in the modern healthcare system.
Chang-Ro Lee, Jung Hun Lee, Moonhee Park, Kwang Seung Park, I. K. Bae, Young Bae Kim, C. Cha, B. Jeong, S. Lee   +8 more
semanticscholar   +1 more source

Evaluating Cefiderocol in the Treatment of Multidrug-Resistant Gram-Negative Bacilli: A Review of the Emerging Data

Infection and Drug Resistance, 2020
Daniele Roberto Giacobbe,1,2 Eugenio Ciacco,3 Corrado Girmenia,4 Federico Pea,5,6 Gian Maria Rossolini,7,8 Giovanni Sotgiu,9 Carlo Tascini,10 Mario Tumbarello,11,12 Pierluigi Viale,5,6 Matteo Bassetti1,2 On behalf of the ISGRI-SITA (Italian Study Group ...
Giacobbe DR, Ciacco E, Girmenia C, Pea F, Rossolini GM, Sotgiu G, Tascini C, Tumbarello M, Viale P, Bassetti M   +9 more
doaj  

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Phosphomimetic mutations near active sites of proteins in Thermus thermophilus suggest a widespread regulatory mechanism

FEBS Open Bio, EarlyView.
In Thermus thermophilus, more than half of the phosphorylation sites identified by proteomic analysis are located near the active site. All phosphomimetic mutants of phosphosites of six enzymes belonging to different families showed severely reduced activity compared with the wild‐type, particularly in the turnover number.
Anzu Nishiwaki, Hiroki Okanishi, Yoshikatsu Kanai, Ryoji Masui   +3 more
wiley   +1 more source

Global escalation in carbapenem-resistant Enterobacterales and carbapenem-resistant Acinetobacter baumannii infections: Serious threat to human health from the pink corner

Biomedical and Biotechnology Research Journal, 2023
Rise in carbapenem-resistant Gram-negative bacterial infections, especially among immunocompromised patients in healthcare settings is an imminent threat as they are difficult to treat and result in a prolonged length of hospital stay, frequent treatment
Mohan Bilikallahalli Sannathimmappa
doaj   +1 more source

Rapid identification of Acinetobacter baumannii, Acinetobacter nosocomialis and Acinetobacter pittii with a multiplex PCR assay

Journal of Medical Microbiology, 2014
Acinetobacter baumannii, Acinetobacter nosocomialis and Acinetobacter pittii are clinically relevant members of the Acinetobacter calcoaceticus–A. baumannii (Acb) complex and important nosocomial pathogens. These three species are genetically closely related and phenotypically similar; however, they differ in their epidemiology ...
Su-Pen Yang, Su-Pen Yang, Shu-Chen Kuo, Shu-Chen Kuo, Shu-Chen Kuo, Te-Li Chen, Te-Li Chen, Shou-Dong Lee, Yi-Tzu Lee, Yi-Tzu Lee, Chang-Phone Fung, Chang-Phone Fung   +11 more
openaire   +3 more sources

Microbial profile of the appendix niche in acute appendicitis: a novel sampling approach

FEBS Open Bio, EarlyView.
This study utilized a novel sampling method, ERAT (i.e. endoscopic retrograde appendicitis treatment)‐guided lumen aspiration, to obtain samples from the appendix, and shotgun metagenomic sequencing was performed for in situ characterization of the appendix microbiome in patients with acute appendicitis.
Huimin Ma, Mingfei Wang, Yanhu Feng, Wanqi Zhang, Wenbo Wang, Yanfeng Xie, Guixiang Kong, Jie Feng, Pengfei Wang, Qi Wang, Xiaojun Huang   +10 more
wiley   +1 more source

Acinetobacter baumannii Efflux Pumps and Antibiotic Resistance

Infection and Drug Resistance, 2020
Acinetobacter baumannii is a nosocomial pathogen and gram-negative coccobacillus that is responsible for opportunistic infections, pneumonia, and infections of the urinary tract, bloodstream, skin, and soft tissue.
Seyyed Naser Abdi, R. Ghotaslou, K. Ganbarov, Ahmad Mobed, A. Tanomand, M. Yousefi, M. Asgharzadeh, Hossein Samadi Kafil   +7 more
semanticscholar   +1 more source