Results 61 to 70 of about 181,625 (306)

Stress History Establishes a Transient Tolerant State That Shapes Antibiotic Survival Upon Resuscitation

Advanced Science, EarlyView.
High‐throughput single‐cell analysis of resuscitating bacteria reveals a starvation‐history‐dependent transiently tolerant subpopulation that survives β$\beta$‐lactam exposure by temporarily reducing growth. Distinct from classical persisters, these actively growing yet dynamically modulated cells dominate survival across clinically relevant antibiotic
Kieran Abbott, Georgeos Hardo, Ruizhe Li, Jack Bradley, Ashraf Zarkan, Somenath Bakshi   +5 more
wiley   +1 more source

Streptavidins Coordinate Biotin Sequestration and Self‐Resistance Within a Biotin‐Pathway Antibiotic Network

Advanced Science, EarlyView.
A conserved genomic region between two streptavidin genes in Streptomyces packages biosynthetic gene clusters for diverse biotin‐pathway antibiotics: acidomycin, stravidin, the new non‐proteinogenic amino acid ANDA, and the new BioA inhibitor α‐methyl‐KAPA.
Sumire Kurosawa, Jingjun Mo, Xiaotong Diao, Feng Xie, Tingting Wang, Haowen Zhao, Dalei Wu, Rolf Müller, Chengzhang Fu   +8 more
wiley   +1 more source

A Dual‐Functional Biohybrid Nanorobot to Synergistically Eradicate Biofilm and Degrade Antibiotic Resistance Genes

Advanced Science, EarlyView.
A biohybrid nanorobot integrating lytic bacteriophage N4 with Pd nanozymes is developed for targeted eradication of multidrug‐resistant E. coli biofilms. Synergistic bacterial lysis and ROS‐mediated oxidation enable simultaneous biofilm removal and antibiotic resistance genes degradation, maintaining high efficacy in complex wastewater environments ...
Junzheng Zhang, Tong Dou, Luokai Wang, Jingxian Yang, Wenrui Wang, Shuaitian Guo, Xiangyu Li, Xuefang Huang, Yunlei Xianyu, Dongsheng Wang   +9 more
wiley   +1 more source

A degenerate PCR-based strategy as a means of identifying homologues of aminoglycoside and ß-lactam resistance genes in the gut microbiota [PDF]

, 2014
peer-reviewedBackground: The potential for the human gut microbiota to serve as a reservoir for antibiotic resistance genes has been the subject of recent discussion. However, this has yet to be investigated using a rapid PCR-based approach.
Cotter, Paul D., Fitzgerald, Gerald F, Fouhy, Fiona, Ross, R Paul, STANTON, CATHERINE   +4 more
core   +1 more source

DNA Nanoarray for Multiplexed RNA Detection With Single‐Molecule Readout

Advanced Science, EarlyView.
A carrier‐based DNA nanoarray integrates programmable nucleic acid hybridization with solid‐state nanopore readout for direct RNA detection at single‐molecule resolution. A ternary encoding system enables 27 carriers with 81 addressable sensing sites, allowing the simultaneous identification of targets spanning a wide size range, from short microRNAs ...
Yunxuan Li, Yesheng Wang, Chunmiao Yu, Siyu Hou, Elli Mylona, Plamena Naydenova, Jingyuan Zhao, Hong Yuan, Jingsong Duan, Hendrik F. P. Runge, Stephen Baker, Jinbo Zhu, Ulrich F. Keyser   +12 more
wiley   +1 more source

Prevalence of Extended-spectrum Beta-lactamase (ESBL), Metallo Beta-lactamase (MBL) and Carbapenemase Producing Acinetobacter Species Isolated from Various Clinical Samples in Tertiary Care Hospital

Journal of Pure and Applied Microbiology
Acinetobacter is an important nosocomial pathogen causing health care associated infections. It is highly antibiotic resistant gram-negative bacilli. The study was done to determine the prevalence of Acinetobacter species isolated from various clinical ...
Manasi Vikas Yadav, Geeta S. Karande, S.N. Karande, S.R. Patil, Shanu Sharma   +4 more
doaj   +1 more source

Prevalence of Acinetobacter Sp. In ICUs and their Antimicrobial Resistance [PDF]

National Journal of Laboratory Medicine, 2013
Introduction: Acinetobacter Sp. are ubiquitous aerobic gram negative coccobacilli that are increasingly responsible for a large number of nosocomial infections.
Merlin Mary Mathew, Shrikara Mallya P.
doaj   +1 more source

Metabolism‐Based Biomarkers for Rapid Phenotypic Antibiotic Susceptibility Testing

Advanced Science, EarlyView.
Metabolic differences emerging after antibiotic exposure provide rapid phenotypic signals of susceptibility and resistance. This review summarizes metabolic biomarkers for rapid phenotypic AST, associated with nutrient uptake, respiratory activity, metabolic reprogramming, and enzymatic function. ABSTRACT The accelerating global crisis of antimicrobial
Sha Yu, Bayinqiaoge, Xi Lu, Xin Wang, Rongfeng Wang, Yi Li, Shi‐Yang Tang, Chengchen Zhang   +7 more
wiley   +1 more source

Antimicrobial resistance pattern in aerobic bacteria isolated from endotracheal aspirate in ventilator-associated pneumonia: Ten years observation from a tertiary care hospital

Journal of Anaesthesiology Clinical Pharmacology
Background and Aims: Ventilator-associated pneumonia (VAP) is a nosocomial infection associated with high morbidity and mortality. This study was undertaken to monitor the trend of the demographical details, comorbid conditions, bacterial etiological ...
Surlu Vidya Rao, Karadka Ramdas Thilakchand, Rekha Boloor, Sucharitha Suresh, Thomas George, Michael LJ. Pais, Ramakrishna Pai Jakribettu, Manjeshwar Shrinath Baliga   +7 more
doaj   +1 more source

Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis [PDF]

, 2018
Background: Infections due to antibiotic-resistant bacteria are threatening modern health care. However, estimating their incidence, complications, and attributable mortality is challenging.
Abu Sin, Muna, Andrasevic, Arjana Tambic, Aracil, Belen, Asensio, Angel, Billstrom, Hanna, Borg, Michael A., Budimir, Ana, Burns, Karen, Canica, Manuela, Cassini, Alessandro, Catry, Boudewijn, Cecchini, Michele, Coignard, Bruno, Colomb-Cotinat, Melanie, Daikos, George L., de Greeff, Sabine C., Deptula, Aleksander, Devleesschauwer, Brecht, Dobreva, Elina Georgieva, Dsstat, Patrizio Pezzotti, Dumpis, Uga, Eckmanns, Tim, Elstrom, Petter, Fernandes, Paulo Andre, Gagliotti, Carlo, Gikas, Achilleas, Guolaugsson, Olafur, Hajdu, Agnes, Haller, Sebastian, Hogberg, Liselotte Diaz, Hopkins, Susan, Hoxha, Ana, Hryniewicz, Waleria, Ivanov, Ivan Nikolaev, Ivanova, Marina, Jalava, Jari, Johnson, Alan, Klavs, Irena, Koek, Mayke B. G., Kolman, Jana, Kontopidou, Flora, Korosec, Ales, Kretzschmar, Mirjam E., Kristinsson, Karl G., Larsson, Sofie, Latour, Katrien, Litvova, Slavka, Liuimiene, Agne, Lyytikainen, Outi, Manageiro, Vera, Martin, Pille, Mertens, Karl, Monen, Jos C. M., Monnet, Dominique L., Murchan, Stephen, Nogueira, Paulo Jorge, Oliveira, Tiago Cravo, Olsen, Stefan Schytte, Ouakrim, Driss Ait, Paphitou, Niki, Perez-Vazquez, Maria, Perrin, Monique, Plachouras, Diamantis, Popescu, Gabriel Adrian, Quattrocchi, Annalisa, Reilly, Jacqui S., Schreterova, Eva, Serban, Roxana Ioana, Simonsen, Gunnar Skov, Sonksen, Ute Wolff, Soprek, Silvija, Stefkovicova, Maria, Strauss, Reinhild, Struelens, Marc J., Struyf, Thomas, Suetens, Carl, Toth, Akos, Tsiodras, Sotirios, Zabicka, Dorota, Zemlickova, Helena   +79 more
core   +6 more sources