Results 51 to 60 of about 63,906 (257)

Extended-Spectrum Cephalosporinase in Acinetobacter baumannii [PDF]

Antimicrobial Agents and Chemotherapy, 2010
ABSTRACT An AmpC-type β-lactamase conferring high-level resistance to expanded-spectrum cephalosporins and monobactams was characterized from an Acinetobacter baumannii clinical isolate. This class C β-lactamase (named ADC-33) possessed a Pro210Arg substitution together with a duplication of an Ala residue
Rodriguez-Martinez, J.-M., Nordmann, P., Ronco, E., Poirel, L.   +3 more
openaire   +2 more sources

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

Screening of bacterial molecules with antagonistic or adjuvant activity [PDF]

, 2010
The Lipopolysaccharides (LPSs) are the major constituents of the outer membrane of Gram-negative bacteria and the interest in their chemical characterization is motivated by the close correlation existing between the structure and the biological activity
Fregolino, Eleonora
core  

Molecular Epidemiology of Integron-Associated Antimicrobial Gene Cassettes in the Clinical Isolates of Acinetobacter baumannii from Northern Taiwan [PDF]

, 2014
Background: The aims of this study were to understand the molecular epidemiology of integron-associated gene cassettes in Acinetobacter baumannii across four hospitals in northern Taiwan and to clarify the relationship between the presence of integrons ...
Lin, Ming-Feng;Liou, Ming-Li;Tu, Chi-Chao;Yeh, Hui-Wen;Lan, Chung-Yu
core   +1 more source

Prevalence of Extensively and Pan-drug-resistant Acinetobacter spp. in Nosocomial Infections in Western Saudi Arabia

Journal of Pure and Applied Microbiology
Multidrug resistance patterns of Acinetobacter spp. have led to their emergence as an important source of nosocomial infections. This study investigated the prevalence and clinical characteristics of Acinetobacter spp.
Hanan S. Al-Ghamdi, Hesham A. Malak, Leena A. Neyaz, Najla A. Obaid, Shmoukh Alghuraibi, Mawadah M.S. AlKashkary, Khaled Elbanna, Iqbal Ahmad, Hussein H. Abulreesh   +8 more
doaj   +1 more source

Extrahuman Epidemiology of Acinetobacter baumannii in Lebanon [PDF]

Applied and Environmental Microbiology, 2015
ABSTRACT The presence of Acinetobacter baumannii outside hospitals is still a controversial issue. The objective of our study was to explore the extrahospital epidemiology of A. baumannii in Lebanon.
Rafei, Rayane, Hamze, Monzer, Pailhories, Hélène, Eveillard, Matthieu, Marsollier, Laurent, Joly-Guillou, Marie-Laure, Dabboussi, Fouad, Kempf, Marie   +7 more
openaire   +3 more sources

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

Clonal spread of bla(OXA-72)-carrying Acinetobacter baumannii sequence type 512 in Taiwan [PDF]

, 2017
This is the first report to show an insidious outbreak of armA-and bla(OXA-72)-carrying Acinetobacter baumannii sequence type 512 (ST512) at a study hospital in northern Taiwan. Multilocus sequence typing revealed that this was a ST512 clone.
Kuo, Han-Yueh;Hsu, Po-Jui;Chen, Jiann-Yuan;Liao, Po-Cheng;Lu, Chia-Wei;Chen, Chang-Hua;Liou, Ming-Li, 郭漢岳;郭弘揚   +1 more
core   +1 more source

Mesoporous Catalytic‐Adsorptive Nanoregulator Orchestrates Biofilm eDNA/LPS Disassembly and TLR9/TLR4 Immune Reprogramming to Resolve Diabetic Foot Infections

Advanced Science, EarlyView.
Chronic diabetic wounds are hindered by a “dual trap” of biofilm resistance and hyperinflammation. A mesoporous catalytic‐adsorptive nano‐regulator is developed to dismantle this barrier through simultaneous eDNA degradation and LPS sequestration. By silencing TLR4/9‐mediated signaling, the platform clears resilient pathogens and reprograms the immune ...
Junfeng Song, Yang Song, Xirui Huang, Xingjin Li, Lifei Gao, Yixiang Wang, Tianbao Zhu, Xiaomin Li, Shuai Wang, Tiancong Zhao, Dongyuan Zhao   +10 more
wiley   +1 more source

Rapid Multiplex Antimicrobial Resistance Profiling and Bacterial Identification by LAP‐MALDI Mass Spectrometry Biotyping

Advanced Science, EarlyView.
Liquid atmospheric pressure matrix‐assisted laser desorption/ionization (LAP‐MALDI) mass spectrometry (MS) provides multiplexed biotyping of microbial cultures using a fast and simple workflow. This is demonstrated for clinically relevant bacteria, resulting in accurate antimicrobial resistance (AMR) detection, speciation by MS/MS sequencing and ...
Lily R. Adair, Shabnam Iyer, Ian M. Jones, Rainer Cramer   +3 more
wiley   +1 more source