Results 131 to 140 of about 1,254 (143)

Disruption of placental ACKR3 impairs growth and hematopoietic development of offspring.

Development
Fukuoka A, Wilson GJ, Pitmon E, Koumbas Foley L, Johnsson H, Pingen M, Graham GJ.   +6 more
europepmc   +1 more source

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ACKR2 limits skin fibrosis and hair loss through IFN‐β

The FASEB Journal, 2021
Abstract The resolution of inflammation facilitates proper wound healing and limits tissue repair short of exaggerated fibrotic scarring. The atypical chemokine receptor (ACKR)2/D6 scavenges inflammatory chemokines, while IFN‐β is a recently unveiled pro‐resolving cytokine.
Sergei Butenko, Nofar Ben Jashar, Tsofiya Sheffer, Edmond Sabo, Sagie Schif‐Zuck, Amiram Ariel   +5 more
openaire   +2 more sources

Expression of ACKR2 in placentas from different types of preeclampsia

Placenta, 2020
The purpose of this study was to investigate the expression of atypical chemokine receptor 2 (ACKR2, D6) in different types of preeclampsia (PE) and its effects on trophoblast proliferation and apoptosis.The subjects were divided into four groups: early-onset PE group (EOPE, n = 30), late-onset PE group (LOPE, n = 30), preterm birth group (PB, n = 30),
Shujun, Yan, Shihong, Cui, Linlin, Zhang, Bo, Yang, Yangyang, Yuan, Xiaofeng, Lv, Han, Fu, Yingying, Li, Chenxi, Huang, Ping, Wang   +9 more
openaire   +2 more sources

Histone Deacetylase Sirtuin 2 Enhances Viability of Trophoblasts Through p65-Mediated MicroRNA-146a/ACKR2 Axis

Reproductive Sciences, 2021
Reduced activity of trophoblast cells is well-recognized to lead to preeclampsia (PE) progression. This study aims to evaluate the roles of histone deacetylase sirtuin 2 (SIRT2) in activity of trophoblast cells and the molecules involved. Differentially expressed genes in placental tissues between PE patients and healthy individuals were screened using
Yingchun Yu, Xiaoqin An, Dongmei Fan
openaire   +2 more sources

Contribution of atypical chemokine receptor 2/ackr2 in bone remodeling

Bone, 2017
Bone remodeling is a tightly regulated process influenced by chemokines. ACKR2 is a decoy receptor for CC chemokines functioning as regulator of inflammatory response. In this study we investigated whether the absence of ACKR2 would affect bone phenotype and remodeling induced by mechanical loading.An orthodontic appliance was placed between incisors ...
Izabella Lucas de Abreu, Lima, Janine Mayra da, Silva, Letícia Fernanda Duffles, Rodrigues, Davidson Frois, Madureira, Angélica Cristina, Fonseca, Gustavo Pompermaier, Garlet, Mauro Martins, Teixeira, Remo Castro, Russo, Sandra Yasuyo, Fukada, Tarcília Aparecida da, Silva   +9 more
openaire   +2 more sources

CCL2/ACKR2 interaction participate in breast cancer metastasis especially in patients with altered lipid metabolism

Medical Hypotheses, 2022
Breast cancer is the most prevalent cancer worldwide and metastasis accounts for the majority of associated deaths. Altered lipid metabolism has been proved to be involved with breast cancer, yet the underlying mechanism in lipid metabolism mediated metastasis in breast cancer remains inadequately understood. Evidence have indicated that adipocytes can
Xiaoying, Zhong, Xuefei, Wang, Qiang, Sun   +2 more
openaire   +2 more sources

The role of ACKR2 in the skin and lung

2021
Abstract not currently available.
openaire   +2 more sources

Role of atypical chemokine receptor ACKR2 in experimental oral squamous cell carcinogenesis

Cytokine, 2019
Chemokines and chemokine receptors are critical in oral tumourigenesis. The atypical chemokine receptor ACKR2 is a scavenger of CC chemokines controlling the availability of these molecules at tumour sites, but the role of ACKR2 in the context of oral carcinogenesis is unexplored.In this study, wild-type (WT) and ACKR2 deficient mice (ACKR2-/-) were ...
Janine Mayra, da Silva, Tálita Pollyanna Moreira, Dos Santos, Adriana Machado, Saraiva, Ana Laura, Fernandes de Oliveira, Gustavo Pompermaier, Garlet, Aline Carvalho, Batista, Ricardo Alves, de Mesquita, Remo Castro, Russo, Tarcília Aparecida, da Silva   +8 more
openaire   +2 more sources

A Novel Autocrine CXCL14/ACKR2 Axis: The Achilles' Heel of Cancer Metastasis?

Clinical Cancer Research, 2019
Abstract Cancer-associated fibroblasts (CAF) are essential for cancer hallmarks. While CAFs are molecularly heterogeneous, a CXCL14-expressing subset has been a critical player in the cancer context. In breast cancer, an autocrine fibroblast CXCL14/ACKR2 axis mediates epithelial-to-mesenchymal transition and endows metastatic traits ...
Qian, Zhang, Nianxin, Zhou, Wei, Wang, Shengtao, Zhou   +3 more
openaire   +2 more sources

Expanding the role of the chemokine network—the multifaceted role of ACKR2

Journal of Leukocyte Biology
Extended repertoire of CXC chemokines engaging ACKR2 and its implications in immune regulation.
Bonecchi, Raffaella, Sozzani, Silvano
openaire   +2 more sources