Results 141 to 149 of about 1,289 (149)
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Contribution of atypical chemokine receptor 2/ackr2 in bone remodeling
Bone, 2017Bone remodeling is a tightly regulated process influenced by chemokines. ACKR2 is a decoy receptor for CC chemokines functioning as regulator of inflammatory response. In this study we investigated whether the absence of ACKR2 would affect bone phenotype and remodeling induced by mechanical loading.An orthodontic appliance was placed between incisors ...
Izabella Lucas de Abreu, Lima +9 more
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Medical Hypotheses, 2022
Breast cancer is the most prevalent cancer worldwide and metastasis accounts for the majority of associated deaths. Altered lipid metabolism has been proved to be involved with breast cancer, yet the underlying mechanism in lipid metabolism mediated metastasis in breast cancer remains inadequately understood. Evidence have indicated that adipocytes can
Xiaoying, Zhong +2 more
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Breast cancer is the most prevalent cancer worldwide and metastasis accounts for the majority of associated deaths. Altered lipid metabolism has been proved to be involved with breast cancer, yet the underlying mechanism in lipid metabolism mediated metastasis in breast cancer remains inadequately understood. Evidence have indicated that adipocytes can
Xiaoying, Zhong +2 more
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The role of ACKR2 in the skin and lung
2021Abstract not currently available.
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Role of atypical chemokine receptor ACKR2 in experimental oral squamous cell carcinogenesis
Cytokine, 2019Chemokines and chemokine receptors are critical in oral tumourigenesis. The atypical chemokine receptor ACKR2 is a scavenger of CC chemokines controlling the availability of these molecules at tumour sites, but the role of ACKR2 in the context of oral carcinogenesis is unexplored.In this study, wild-type (WT) and ACKR2 deficient mice (ACKR2-/-) were ...
Janine Mayra, da Silva +8 more
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A Novel Autocrine CXCL14/ACKR2 Axis: The Achilles' Heel of Cancer Metastasis?
Clinical Cancer Research, 2019Abstract Cancer-associated fibroblasts (CAF) are essential for cancer hallmarks. While CAFs are molecularly heterogeneous, a CXCL14-expressing subset has been a critical player in the cancer context. In breast cancer, an autocrine fibroblast CXCL14/ACKR2 axis mediates epithelial-to-mesenchymal transition and endows metastatic traits ...
Qian, Zhang +3 more
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Expanding the role of the chemokine network—the multifaceted role of ACKR2
Journal of Leukocyte BiologyExtended repertoire of CXC chemokines engaging ACKR2 and its implications in immune regulation.
Bonecchi, Raffaella, Sozzani, Silvano
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International Immunopharmacology
This study aimed to explore the potential bind of Receptor Activity-Modifying Protein 3 (RAMP3) with atypical chemokine receptor 2 (ACKR2), and their cooperative regulation on the degradation of the immunosuppressive chemokine CCL2 in the tumor microenvironment of HCC.
Lan, Yang +3 more
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This study aimed to explore the potential bind of Receptor Activity-Modifying Protein 3 (RAMP3) with atypical chemokine receptor 2 (ACKR2), and their cooperative regulation on the degradation of the immunosuppressive chemokine CCL2 in the tumor microenvironment of HCC.
Lan, Yang +3 more
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The link between serum ACKR2 level and Crohn's Disease and its activity
2021Backgrounds/Aim: Atypical chemokine receptor (ACKR) family suppresses chemokine response and keeps the inflammatory state under control. This study investigated ACKR2 serum levels, which are thought to have an effect on the extreme inflammatory state in Crohn's disease (CD).Methods: Active and newly diagnosed Crohn's patients under treatment ...
ÇİFÇİ, Sami +5 more
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IMPORTANCE OF ACKR2 GENE EXPRESSION IN THE EVALUATION OF MULTIPLE SCLEROSIS DISEASE
Direct interactions between cells, such as those between the cell and the extracellular matrix, are extremely important for the development and function of multicellular organisms. Since peptide hormones, neuropeptides and growth factors do not have the ability to cross the plasma membrane of their target cells like cytokines, they bind to receptors onopenaire +1 more source