Results 31 to 40 of about 1,289 (149)

Single-Cell Profiling Reveals Conserved Differentiation and Partial EMT Programs Orchestrating Ecosystem-Level Antagonisms in Head and Neck Cancer. [PDF]

J Cell Mol Med
ABSTRACT Head and neck squamous cell carcinoma (HNSC) exhibits profound intratumoral heterogeneity, driven by dynamic interactions between malignant cells and the tumour microenvironment (TME). Using consensus non‐negative matrix factorisation (cNMF) on multi‐site HNSC single‐cell transcriptomes, we resolving conserved meta‐programs define cellular ...
Jiang D, Wu X, Deng Y, Yang X, Wang Z, Tang Y, He L, He X.   +7 more
europepmc   +2 more sources

CXCL14 promotes metastasis of non-small cell lung cancer through ACKR2-depended signaling pathway. [PDF]

Int J Biol Sci, 2023
Background: Lung cancer is a malignant tumor with metastatic potential. Chemokine ligand 14 (CXCL14) has been reported to be associated with different cancer cell migration and invasion. However, few studies have explored the function of CXCL14 and its specific receptor in lung cancer metastasis.
Chang TM, Chiang YC, Lee CW, Lin CM, Fang ML, Chi MC, Liu JF, Kou YR.   +7 more
europepmc   +3 more sources

CXCL10 Is an Agonist of the CC Family Chemokine Scavenger Receptor ACKR2/D6 [PDF]

Cancers, 2021
Atypical chemokine receptors (ACKRs) are important regulators of chemokine functions. Among them, the atypical chemokine receptor ACKR2 (also known as D6) has long been considered as a scavenger of inflammatory chemokines exclusively from the CC family. In this study, by using highly sensitive β-arrestin recruitment assays based on NanoBiT and NanoBRET
Andy Chevigné, Bassam Janji, Max Meyrath, Nathan Reynders, Giulia D’Uonnolo, Tomasz Uchański, Malina Xiao, Guy Berchem, Markus Ollert, Yong-Jun Kwon, Muhammad Zaeem Noman, Martyna Szpakowska   +11 more
openaire   +3 more sources

ACKR2: An Atypical Chemokine Receptor Regulating Lymphatic Biology [PDF]

Frontiers in Immunology, 2017
The lymphatic system plays an important role in the induction of the immune response by transporting antigens, inflammatory mediators, and leukocytes from peripheral tissues to draining lymph nodes. It is emerging that lymphatic endothelial cells (LECs) are playing an active role in this context via the expression of chemokines, inflammatory mediators ...
O. Bonavita, V. Mollica Poeta, E. Setten, M. Massara, R. Bonecchi   +4 more
openaire   +2 more sources

ACKR2: Nature’s Decoy Receptor Lures Unsuspecting Chemokines in Psoriasis [PDF]

Journal of Investigative Dermatology, 2017
While we know much about the processes mediated by the Th17 inflammatory pathway that is crucial in psoriasis, we actually know little about the processes by which most psoriatic patients maintain what grossly looks like non-inflamed, normal skin in the face of massive inflammatory changes in nearby affected skin. Other molecular regulators that defend
Tomotaka, Mabuchi, Samuel T, Hwang
openaire   +2 more sources

Chemoradiotherapy-induced ACKR2⁺ tumor cells drive CD8⁺ T cell senescence and cervical cancer recurrence. [PDF]

Cell Rep Med
Tumor recurrence after chemoradiotherapy is challenging to overcome, and approaches to predict the recurrence remain elusive. Here, human cervical cancer tissues before and after concurrent chemoradiotherapy (CCRT) analyzed by single-cell RNA sequencing reveal that CCRT specifically promotes CD8+ T cell senescence, driven by atypical chemokine receptor
Dai D, Pei Y, Zhu B, Wang D, Pei S, Huang H, Zhu Q, Deng X, Ye J, Xu J, Chen X, Huang M, Xiao Y.   +12 more
europepmc   +3 more sources

Chemokines: Orchestration of the Tumor Microenvironment and Control of Hepatocellular Carcinoma Progression. [PDF]

Cancer Med
ABSTRACT Chemokines, a family of chemotactic cytokines, play a central role in shaping the tumor microenvironment (TME) and in influencing the progression of hepatocellular carcinoma (HCC), a well‐known inflammation‐related cancer. This review addresses the intricate interplay between chemokines and HCC and highlights their multifaceted role.
Yang J, Lu H, Li L.
europepmc   +2 more sources

Die Beeinflussung des akuten und chronischen Ischämie-Reperfusionsschadens in der Niere durch das Chemokin-bindende Molekül ACKR2 [PDF]

Nach einem Ischämie-Reperfusionsschaden in der Niere erlaubt ein Rückgang der Entzündungsreaktion eine Regeneration und Heilung des Tubulusepithels. Wenn die Entzündungsreaktion aber persistiert oder gar voranschreitet, kommt es zu einem andauernden ...
Lux, Moritz
core   +2 more sources

Control of Cytoskeletal Dynamics by β-Arrestin1/Myosin Vb Signaling Regulates Endosomal Sorting and Scavenging Activity of the Atypical Chemokine Receptor ACKR2

Vaccines, 2020
The atypical chemokine receptor ACKR2, formerly named D6, is a scavenger chemokine receptor with a non-redundant role in the control of inflammation and immunity. The scavenging activity of ACKR2 depends on its trafficking properties, which require actin
Alessandro Vacchini, Cinzia Cancellieri, Samantha Milanesi, Sabrina Badanai, Benedetta Savino, Francesco Bifari, Massimo Locati, Raffaella Bonecchi, Elena Monica Borroni   +8 more
doaj   +1 more source

The atypical chemokine receptor ACKR2 suppresses Th17 responses to protein autoantigens [PDF]

Immunology & Cell Biology, 2014
Chemokine‐directed leukocyte migration is a critical component of all innate and adaptive immune responses. The atypical chemokine receptor ACKR2 is expressed by lymphatic endothelial cells and scavenges pro‐inflammatory CC chemokines to indirectly subdue leukocyte migration.
Hansell, Chris AH, MacLellan, Lindsay M, Oldham, Rachel S, Doonan, James, Chapple, Katie J, Anderson, Elinor JR, Linington, Christopher, McInnes, Iain B, Nibbs, Robert JB, Goodyear, Carl S   +9 more
openaire   +2 more sources