Placental chemokine compartmentalisation: a novel mammalian molecular control mechanism [PDF]
, 2019 Atypical chemokine receptor 2 (ACKR2) is a chemokine-scavenging receptor. ACKR2–/–embryos display a reduction in size of a novel, to our knowledge, embryonic skin macrophage population referred to as ‘intermediate’ cells. CC chemokine receptor 2 (CCR2)–/–
Bartolini, Robin +7 more
core +2 more sources
The Role of Atypical Chemokine Receptor D6 (ACKR2) in Physiological and Pathological Conditions; Friend, Foe, or Both? [PDF]
Front Immunol, 2022 Chemokines exert crucial roles in inducing immune responses through ligation to their canonical receptors. Besides these receptors, there are other atypical chemokine receptors (ACKR1–4) that can bind to a wide range of chemokines and carry out various functions in the body.
Gowhari Shabgah A +6 more
europepmc +4 more sources
Immune modulation by virus-encoded secreted chemokine binding proteins [PDF]
, 2015 Chemokines are chemoattractant cytokines that mediate the migration of immune cells to sites of infection which play an important role in innate and adaptive immunity. As an immune evasion strategy, large DNA viruses (herpesviruses and poxviruses) encode
Alcamí, Antonio +2 more
core +1 more source
The atypical chemokine receptor-2 does not alter corneal graft survival but regulates early stage of corneal graft induced lymphangiogenesis [PDF]
, 2018 Open Access via Springer Compact Agreement Funding: Saving Sight in Grampian provided financial support in the forming of Saving Sight in Grampian funding.
Forrester, John V. +3 more
core +1 more source
The chemokine scavenging receptor D6/ACKR2 is a target of miR-146a in thyroid cancer [PDF]
Genes & Cancer, 2017 We have previously shown that miR-146a, a NF-κB-regulated microRNA, is strongly expressed in human specimens and cell lines derived from anaplastic thyroid carcinomas (ATC) where it mediates some of the NF-κB pro-tumorigenic functions. By using a bioinformatic analysis, we identified the chemokine scavenger receptor D6/ ACKR2 as a target of miR146a in ...
Francesco Pacifico +7 more
openaire +5 more sources
Transfection of Sertoli cells with androgen receptor alters gene expression without androgen stimulation [PDF]
, 2015 Background: Androgens play an important role for the development of male fertility and gained interest as growth and survival factors for certain types of cancer.
Bergmann, M. +8 more
core +3 more sources
Expert Review of Clinical Immunology, 2023 ACKR2 is a scavenger for most inflammation-related CC chemokines. This study aimed to assess the pan-cancer prognostic significance of ACKR2 and the genetic and epigenetic mechanisms underlying its dysregulation. Pan-cancer data from The Cancer Genome Atlas (TCGA), Therapeutically Applicable Research to Generate Effective Treatments (TARGET) and The ...
Hongxiu Dong +4 more
openaire +2 more sources
Role of Atypical Chemokine Receptors in Microglial Activation and Polarization. [PDF]
, 2017 Inflammatory reactions occurring in the central nervous system (CNS), known as neuroinflammation, are key components of the pathogenic mechanisms underlying several neurological diseases.
Del Prete, A. +3 more
core +1 more source
Intrapericardial Administration of Secretomes from Menstrual Blood-Derived Mesenchymal Stromal Cells: Effects on Immune-Related Genes in a Porcine Model of Myocardial Infarction. [PDF]
, 2022 Acute myocardial infarction (AMI) is a manifestation of ischemic heart disease where the immune system plays an important role in the re-establishment of homeostasis.
Blanco, Virginia +11 more
core +1 more source
Renal Protection by Genetic Deletion of the Atypical Chemokine Receptor ACKR2 in Diabetic OVE Mice [PDF]
Journal of Diabetes Research, 2016 In diabetic nephropathy (DN) proinflammatory chemokines and leukocyte infiltration correlate with tubulointerstitial injury and declining renal function. The atypical chemokine receptor ACKR2 is a chemokine scavenger receptor which binds and sequesters many inflammatory CC chemokines but does not transduce typical G-protein mediated signaling events ...
Shirong Zheng +6 more
openaire +3 more sources