Proximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging
Aging Cell, Volume 25, Issue 2, February 2026.Mouse models revealed age‐associated increased circumferential stiffness of the proximal pulmonary artery that was associated with reorientation of collagen and decreased function of the lung and right ventricle. Age‐related transcriptional changes were indicative of senescence, ECM turnover, TGFβ signaling, and altered intercellular signaling among ...
Ruben De Man +22 more
wiley +1 more source
Single-Cell Transcriptomes Reveal a Complex Cellular Landscape in the Middle Ear and Differential Capacities for Acute Response to Infection. [PDF]
, 2020 Single-cell transcriptomics was used to profile cells of the normal murine middle ear. Clustering analysis of 6770 transcriptomes identified 17 cell clusters corresponding to distinct cell types: five epithelial, three stromal, three lymphocyte, two ...
Draf, Clara +6 more
core
Atlas of the anatomical localization of atypical chemokine receptors in healthy mice. [PDF]
, 2023 Atypical chemokine receptors (ACKRs) scavenge chemokines and can contribute to gradient formation by binding, internalizing, and delivering chemokines for lysosomal degradation.
Ameti, Rafet +8 more
core +1 more source
Analysis of lung stromal expression of the atypical chemokine receptor ACKR2 reveals unanticipated expression in murine blood endothelial cells [PDF]
European Journal of Immunology, 2020 Abstract Analysis of chemokine receptor, and atypical chemokine receptor, expression is frequently hampered by the lack of availability of high‐quality antibodies and the species specificity of those that are available. We have previously described methodology utilizing Alexa‐Fluor‐labeled chemokine ligands as versatile reagents to ...
Hansell, Christopher A.H. +5 more
openaire +3 more sources
Redundancy and robustness versus division of labour and specialization in innate immunity [PDF]
, 2018 Support of Italian Association for Cancer Research (AIRC IG-19014 and AIRC 5×1000), Ministero della Salute (RF-2011-02348358 and RF-2013-02355470), Ministry of Education, University and Research (PRIN 2015YYKPNN) and European Research Council (ERC − N ...
Mantovani, A
core +1 more source
Chemokine receptors ACKR2 and CCR1 coordinate macrophage dynamics and mammary gland development [PDF]
, 2019 AbstractMacrophages are key regulators of developmental processes, including those involved in mammary gland development. We previously demonstrated that the atypical chemokine receptor, ACKR2, contributes to control of ductal epithelial branching in the developing mammary gland by regulating macrophage dynamics.
Wilson, Gillian J +6 more
openaire +1 more source
Multi-walled carbon nanotube-induced genotoxic, inflammatory and pro-fibrotic responses in mice: Investigating the mechanisms of pulmonary carcinogenesis [PDF]
, 2017 The International Agency for Research on Cancer has classified one type of multi-walled carbon nanotubes (MWCNTs) as possibly carcinogenic to humans. However, the underlying mechanisms of MWCNT- induced carcinogenicity are not known.
Aziz, Syed Abdul +9 more
core +2 more sources
ACKR2 contributes to pulmonary dysfunction by shaping CCL5:CCR5-dependent recruitment of lymphocytes during influenza A infection in mice [PDF]
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2020 Inflammation triggered by influenza A virus (IAV) infection is important for viral clearance, induction of adaptive responses, and return to lung homeostasis. However, an exaggerated immune response, characterized by the overproduction of chemokines, can lead to intense lung injury, contributing to mortality.
Luciana P. Tavares +14 more
openaire +2 more sources
The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors
British Journal of Pharmacology, Volume 182, Issue S1, Page S24-S151, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +206 more
wiley +1 more source
The N-terminal Region of the Atypical Chemokine Receptor ACKR2 Is a Key Determinant of Ligand Binding [PDF]
Journal of Biological Chemistry, 2014 The atypical chemokine receptor, ACKR2 is a pivotal regulator of chemokine-driven inflammatory responses and works by binding, internalizing, and degrading inflammatory CC-chemokines. ACKR2 displays promiscuity of ligand binding and is capable of interacting with up to 14 different inflammatory CC-chemokines.
Hewit, Kay D. +3 more
openaire +3 more sources