Results 71 to 80 of about 1,254 (143)
Biased and g protein-independent signaling of chemokine receptors [PDF]
, 2014 Biased signaling or functional selectivity occurs when a 7TM receptor preferentially activates one of several available pathways. It can be divided into three distinct forms: ligand bias, receptor bias, and tissue or cell bias, where it is mediated by ...
Larsen, Olav +3 more
core +3 more sources
CCL2/CCR2 Signalling in Mesenchymal Stem/Progenitor Cell Recruitment and Fracture Healing in Mice
Journal of Cellular and Molecular Medicine, Volume 28, Issue 24, December 2024.ABSTRACT Macrophage efferocytosis (clearance of apoptotic cells) is crucial for tissue homeostasis and wound repair, where macrophages secrete factors that promote resolution of inflammation and regenerative signalling. This study examined the role of efferocytic macrophage‐associated CCL2 secretion, its influence on mesenchymal stem/progenitor cell ...
Rahasudha Kannan +9 more
wiley +1 more source
The Interplay Between Lymphatic Vessels and Chemokines [PDF]
, 2019 Chemokines are a family of small protein cytokines that act as chemoattractants to migrating cells, in particular those of the immune system. They are categorized functionally as either homeostatic, constitutively produced by tissues for basal levels of ...
Rae H. Farnsworth +8 more
core +1 more source
Muscle cell‐derived Ccl8 is a negative regulator of skeletal muscle regeneration
The FASEB Journal, Volume 38, Issue 14, 31 July 2024.Immune cells infiltrating injured skeletal muscles produce the chemokine Ccl8, which suppresses muscle regeneration. Muscle stem cells (or myogenic progenitor cells) also express Ccl8. The results of our in vitro and in vivo studies suggest that muscle cell‐derived Ccl8 has a negative role in muscle regeneration.
A. Boss‐Kennedy +5 more
wiley +1 more source
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2019 In experimental obesity, the hypothalamus is affected by an inflammatory response activated by dietary saturated fats. This inflammation is triggered as early as one day after exposure to a high-fat diet, and during its progression, there is recruitment of inflammatory cells from the systemic circulation.
Fioravante, Milena +12 more
openaire +2 more sources
ANALYSIS OF BIASED SIGNALING IN THE CHEMOKINE SYSTEM [PDF]
, 2016 Chemokines constitute a family of almost 50 small secreted cytokines, recognized by about 20 different 7TM spanning G protein coupled receptors (GPCRs), that activating pertussis toxin sensitive G proteins induce cell migration.
A. Vacchini
core +1 more source
Investigating the role of Atypical Chemokine Receptor 3 in cancer development [PDF]
, 2020 Atypical Chemokine Receptor 3 (ACKR3) is a seven-transmembrane spanning receptor with pleiotropic functions in development, homeostasis and pathophysiology.
Karatza, Angeliki
core
O receptor atípico de quimiocinas ACKR2 exerce papel protetor na ascaridíase larval por Ascaris suum em modelo murino [PDF]
, 2017 Human ascariasis is a highly prevalent geohelmintosis and affects millions of people worldwide and is associated with significant morbidity. This helminthiasis is related to precarious conditions of basic sanitation in addition to reduced socioeconomic ...
Renata Barbosa Peixoto
core
The role of ACKR2 in inflammatory pathologies [PDF]
, 2015 Chemokines are a highly conserved family of chemoattractant cytokines that are key to the movement of cells around the body under both inflammatory and homeostatic conditions. Chemokines bind to seven transmembrane G protein coupled receptors that signal
Pallas, Kenneth James
core +1 more source
Corrigendum: ACKR2: An Atypical Chemokine Receptor Regulating Lymphatic Biology [PDF]
Frontiers in Immunology, 2017 Ornella Bonavita +9 more
openaire +2 more sources