Results 71 to 80 of about 1,289 (149)

CXCL14 Promotes Skeletal Muscle Mass Growth and Attenuates Lipopolysaccharide‐ and Dexamethasone‐Induced Muscle Atrophy in Cultured Myotubes and Mouse Models

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 5, October 2025.
ABSTRACT Background Skeletal muscle mass is regulated by secretory factors derived from myofibers and muscle‐resident cells. Identifying these factors and understanding their mechanisms is critical for combating muscle wasting disorders. This experimental study investigates the role of CXCL14, a chemokine primarily secreted by fibro‐adipogenic ...
Bagus Sarmito, Younjeong Oh, Nurkyz Alymkulova, Jeong Kyo Yoon   +3 more
wiley   +1 more source

Resolution of inflammation: a new therapeutic frontier [PDF]

, 2016
Dysregulated inflammation is a central pathological process in diverse disease states. Traditionally, therapeutic approaches have sought to modulate the pro- or anti-inflammatory limbs of inflammation, with mixed success.
A Ariel, A Ariel, A Basran, A Boasso, A Chatterjee, A Devitt, A Kovalenko, A Recchiuti, A Recchiuti, A Rossi, AB Shyu, AE Leitch, AE Leitch, AG Rossi, AG Rossi, AG Rossi, AG Rossi, AI Medeiros, AJ Degraaf, AJ O'Brien, AL Alessandri, AL Alessandri, AL Robertson, AP Cope, AW Segal, B Amulic, B Bondue, B Geering, B Gemici, B Leon, BA Zabel, BJ Evans, C Favas, C Godson, C Qin, C Schauer, C von Roretz, C Yao, CA Wijbrandts, CC Mihalache, CD Buckley, CD Buckley, CD Gregory, CE Clay, CH Fong, CN Serhan, CN Serhan, CN Serhan, CW Yang, D Bhaumik, D El Kebir, D Park, DA Isenberg, DA Sawatzky, DC Cara, Derek W. Gilroy, DH Rodrigues, DR Gude, DS Straus, DW Gilroy, DW Gilroy, DW Gilroy, E Carballo, E Carballo, E Perdiguero, E Tili, EB Wilson, EE McGrath, EL Hahn, ES Mocarski, EY Chung, F Mariani, FJ Sheedy, FK Chan, FK Swirski, FM Menzies, FN Gavins, FS Machado, G D'Agostino, G Fredman, G Song, G Stoecklin, GA Rabinovich, GJ Bellingan, GJ Graham, GJ Graham, GL Bannenberg, H Braley-Mullen, H Muhl, H Nakano, H Seki, HJ Anders, HT Chung, I Allaeys, I McConnell, I Mitroulis, I Mitroulis, I Sauer, IK Poon, J Bystrom, J Bystrom, J Bystrom, J Gong, J Hopkins, J Liang, J Liu, J Liu, J Newson, J Savill, J Savill, J Seok, James N. Fullerton, JD Langereis, JD Pollock, JL Cash, JL Wallace, JM Gonzalez-Navajas, JM Schwab, JP Vago, JR Brown, JR Teijaro, JW Zmijewski, K Ersland, K Horino, K Lauber, K Linker, K Matsushita, K Miles, K Phillips, K Sasaki, K Takao, K Uchida, K Vyas, KD Taganov, KE Blume, KH Weylandt, KP High, L Arnold, L Chen, L Li, L Sun, LJ Harvey, LM Wakim, LP Sousa, LP Sousa, LR Prince, LS van Rijt, M Back, M Brittan, M Drechsler, M Feoktistova, M Kool, M Lagarde, M Mavers, M Perretti, M Perretti, M Piecyk, M Romano, M Romano, M Rosas, M Singh, M Vukmanovic-Stejic, MA Nahid, MC Martin, MF Schmidt, MG Johnston, MM Chan, MM Matzelle, MM Perry, MR Elliott, MR Jones, MR Junttila, MS Bynoe, MS Chapman, MT Elola, N Chiang, N Chiang, N Dufton, NC Henderson, NM Reddy, P Anderson, P Anderson, P Libby, P Ramachandran, P Sampath, PA Insel, Q Remijsen, R Gyurko, R Mounier, R Mukhopadhyay, R Pettipher, R Rajakariar, R Rajakariar, R Tomasini, RJ Nibbs, RL Ogilvie, RL Ogilvie, RM Day, RM Dores, RM Thurlings, RN Cahill, S Bala, S Brown, S Divanovic, S Krishnamoorthy, S Mi, S Parathath, S Schif-Zuck, S Uderhardt, S Yazid, S Yona, SB Berger, SG Trivedi, SJ Gardai, SJ Nicholls, SW Jones, SW Ryter, T Brzoska, T Hisada, T Lawrence, T Montero-Melendez, T Shay, T Vanden Berghe, U Koedel, UE Knies, V Deretic, VA Fadok, VA Fadok, VA Fadok, VA Fadok, VA Fadok, W Jenner, WH Shao, WJ Kim, WR Hansen, Y Fang, Y Fang, Y Okabe, Y Uehara, YL Chen   +239 more
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Genetically Determined Inflammation‐Related Proteins in Asthma and Type‐2 Signatures

Allergy, Volume 80, Issue 6, Page 1702-1714, June 2025.
This study investigates the association between genetic variation and inflammation‐related plasma proteins, and the differences in the proteins genetically determined between subjects with type‐2 signatures and/or asthma. Our findings suggest a strong contribution of genetic variation to the inflammation‐related proteome.
Natalia Hernandez‐Pacheco, Sophia Björkander, Simon Kebede Merid, Maura Kere, Ashish Kumar, Susanna Klevebro, Ida Mogensen, Sandra Ekström, Christer Janson, Lena Palmberg, Marianne van Hage, Anders Mälarstig, Anne‐Sophie Merritt, Göran Pershagen, Anna Bergström, Inger Kull, Jochen M. Schwenk, Erik Melén   +17 more
wiley   +1 more source

Cross-genetic determination of maternal and neonatal immune mediators during pregnancy. [PDF]

, 2018
BACKGROUND:The immune system plays a fundamental role in development during pregnancy and early life. Alterations in circulating maternal and neonatal immune mediators have been associated with pregnancy complications as well as susceptibility to ...
Ashwood, Paul, Croen, Lisa A, DeLorenze, Gerald N, Heuer, Luke S, Jones, Karen L, Kharrazi, Martin, Traglia, Michela, Van de Water, Judy, Weiss, Lauren A, Yolken, Robert   +9 more
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Relationship Between MCP‐1 Levels in GCF and Periodontitis: A Systematic Review With Meta‐Analysis and Analysis of Molecular Interactions

Journal of Cellular and Molecular Medicine, Volume 29, Issue 9, May 2025.
ABSTRACT Monocyte chemoattractant protein 1 (MCP‐1) is involved in monocyte chemotaxis, endothelial activation and regulation of leukocyte function in biological activities that promote inflammation, such as in periodontitis. A systematic review and meta‐analysis was conducted with the primary objective of investigating the roles of MCP‐1 in the ...
Mario Alberto Alarcón‐Sánchez, Ruth Rodríguez‐Montaño, Sarah Monserrat Lomelí‐Martínez, Artak Heboyan   +3 more
wiley   +1 more source

DOWN-REGULATION OF ATYPICAL CHEMOKINE RECEPTOR ACKR2/D6 EXPRESSION BY HEMATOPOIETIC PROGENITORS PROMOTES MYELOID CELL MOBILIZATION AND DIFFERENTIATION [PDF]

, 2017
Chemokines and chemokine receptors are key mediators of inflammation and important regulators of leukocyte migration in homeostatic conditions as well as during infection and cancer.
O. Bonavita
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Transitional CXCL14+ cancer‐associated fibroblasts enhance tumour metastasis and confer resistance to EGFR‐TKIs, revealing therapeutic vulnerability to filgotinib in lung adenocarcinoma

Clinical and Translational Medicine, Volume 15, Issue 4, April 2025.
Single‐cell analysis identifies transitional CXCL14+ myofibroblastic cancer‐associated fibroblasts (myCAFs) predominantly exist in the advanced‐stage lung adenocarcinoma (LUAD). Transitional CXCL14+ myCAFs fuel metastasis by promoting epithelial–mesenchymal transition (EMT) and angiogenesis on the spatial level.
Weijiao Xu, Haitang Yang, Ke Xu, Anshun Zhu, Sean R. R. Hall, Yunxuan Jia, Baicheng Zhao, Enshuo Zhang, Gang Liu, Jianlin Xu, Thomas M. Marti, Ren‐Wang Peng, Patrick Dorn, Yongliang Niu, Xufeng Pan, Yajuan Zhang, Feng Yao   +16 more
wiley   +1 more source

A Novel ACKR2-Dependent Role of Fibroblast-Derived CXCL14 in Epithelial-to-Mesenchymal Transition and Metastasis of Breast Cancer [PDF]

Clinical Cancer Research, 2019
Abstract Purpose: Fibroblasts expressing the orphan chemokine CXCL14 have been previously shown to associate with poor breast cancer prognosis and promote cancer growth. This study explores the mechanism underlying the poor survival associations of stromal CXCL14.
Elin Sjöberg, Max Meyrath, Laura Milde, Mercedes Herrera, John Lövrot, Daniel Hägerstrand, Oliver Frings, Margarita Bartish, Charlotte Rolny, Erik Sonnhammer, Andy Chevigné, Martin Augsten, Arne Östman   +12 more
openaire   +2 more sources

Transcriptomic and Histological Characterization of Telocytes in the Human Dorsal Root Ganglion

Journal of Comparative Neurology, Volume 533, Issue 3, March 2025.
Schematic summary of the presence and characteristics of putative telocytes in human dorsal root ganglia (DRG). In‐depth in silico analysis of sequencing data suggests the presence of nine distinct telocyte subtypes in human DRG and defined more than 3000 predicted receptor–ligand interactions between neurons and telocytes.
Rainer V. Haberberger, Dusan Matusica, Stephanie Shiers, Ishwarya Sankaranarayanan, Theodore J. Price   +4 more
wiley   +1 more source

Beeinflussung der diabetischen Nephropathie durch den atypischen Chemokinrezeptor 2 [PDF]

, 2023
Die diabetische Nephropathie gehört zu den bedeutendsten Pathologien der Nephrologie mit hoher klinischer Relevanz. Inflammatorische Prozesse mit leukozytärer Infiltration in das renale Gewebe spielen eine wichtige pathophysiologische Rolle, tragen zur ...
Mertsch, Manuela
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