Results 91 to 100 of about 7,261 (245)

Dystrophia Smolandiensis is characterized by a novel NQO1 variant and a distinct phenotype from COL17A1‐associated epithelial recurrent erosion dystrophy

open access: yesActa Ophthalmologica, EarlyView.
Abstract Purpose To determine the molecular cause of the two epithelial recurrent erosion dystrophies, Dystrophia Smolandiensis and Dystrophia Helsinglandica, and to identify phenotypic differences between the two conditions. Methods DNA samples and clinical data from structured interview records were obtained from the Swedish families in which ...
Karl De Geer   +5 more
wiley   +1 more source

Clinical characteristics of the asthma–COPD overlap syndrome – a systematic review

open access: yesInternational Journal of COPD, 2015
Mia Nielsen,1 Camilla Boslev Bårnes,1 Charlotte Suppli Ulrik1,2 1Department of Pulmonary Medicine, Hvidovre Hospital, 2University of Copenhagen, Copenhagen, Denmark Background and objective: In recent years, the so-called asthma–chronic ...
Nielsen M, Bårnes CB, Ulrik CS
doaj  

Decoding neuronal vulnerability: Multidimensional analysis of D1R‐ and D2R‐ medium‐sized spiny neurons in Huntington's disease

open access: yesBrain Pathology, EarlyView.
D1R and D2R MSNs show distinct responses to Huntington's pathology. G&T‐sequencing of pre‐symptomatic MSNs reveals global LINE‐1 downregulation. While D1R‐MSNs display early transcriptomic changes (OXPHOS/translation upregulation) and reduced mutant huntingtin aggregation, D2R‐MSNs exhibit higher nuclear mHTT accumulation and greater CAG somatic ...
Guendalina Bergonzoni   +22 more
wiley   +1 more source

Fractional exhaled nitric oxide levels in asthma–COPD overlap syndrome: analysis of the National Health and Nutrition Examination Survey, 2007–2012

open access: yesInternational Journal of COPD, 2016
Tadahiro Goto, Carlos A Camargo Jr, Kohei Hasegawa Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA Purpose: Recent studies propose TH2-mediated inflammation in patients with asthma&ndash ...
Goto T, Camargo CA Jr, Hasegawa K
doaj  

Liquid Biopsy and Multi‐Cancer Early Detection Tests for Cancer Screening: A Scoping Review

open access: yesClinical Genetics, EarlyView.
There is a large body of evidence on liquid biopsy and multi‐cancer detection tests for cancer screening. Most studies addressed test performance outcomes, while fewer addressed clinical outcomes, implementation, and cost‐effectiveness. No studies evaluated cancer mortality.
Tessa Robinson   +6 more
wiley   +1 more source

Efficient exact formulations for the flexible job shop scheduling with flexible maintenance

open access: yesInternational Transactions in Operational Research, EarlyView.
Abstract In modern manufacturing systems, integrating preventive maintenance into production scheduling is essential to ensure operational efficiency and equipment reliability. This paper addresses the flexible job shop scheduling problem under machine unavailability constraints caused by non‐fixed maintenance tasks.
Tom Perroux   +4 more
wiley   +1 more source

An Electronic Health Record “Nudge” to Reduce Antipsychotic Medication Prescribing for Primary Care Patients With Dementia: A Pragmatic RCT

open access: yesJournal of the American Geriatrics Society, EarlyView.
ABSTRACT Background We hypothesized that an electronic health record (EHR) alert grounded in behavioral science could reduce new antipsychotic medication prescriptions for older adults with dementia. Methods We conducted a pragmatic clinical trial at a large academic health system, randomizing providers to receive the alert (intervention) or not ...
Catherine A. Sarkisian   +9 more
wiley   +1 more source

Inflammatory biomarkers in asthma-COPD overlap syndrome

open access: yesInternational Journal of COPD, 2016
Seiichi Kobayashi, Masakazu Hanagama, Shinsuke Yamanda, Masatsugu Ishida, Masaru YanaiDepartment of Respiratory Medicine, Japanese Red Cross Ishinomaki Hospital, Ishinomaki, JapanBackground: The clinical phenotypes and underlying mechanisms of asthma ...
Kobayashi S   +4 more
doaj  

Organising organic: a Foucauldian analysis of the regulation of organic food production [PDF]

open access: yes
Early in the life of this thesis, Britain became the world's third largest consumer of organic produce with sales of organic food exceeding one billion pounds.
Skinner, Diane Elizabeth
core  

A Robust and Effective GNSS/INS Integration Optimizing Cost and Effort [PDF]

open access: yes, 2009
Meeting all requirements for ying approaches in bad weather conditions is one of the most demanding and challenging aspects of present day airborne navigation.
Rippl, Markus   +2 more
core  

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