Results 141 to 150 of about 8,833 (185)
Variable domain glycosylation of ACPA-IgG: A missing link in the maturation of the ACPA response?
Clinical Immunology, 2018 Anti-citrullinated Protein Antibodies (ACPA) are excellent markers for Rheumatoid arthritis (RA) and are postulated to have a pathogenic role in the disease process. A multistep model for the evolution of the ACPA response in RA was proposed in which an initial break of tolerance causes, as "first hit", "silent" production of ACPA without any clinical ...
Hans Ulrich Scherer +2 more
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Comparison of serological markers between ACPA+ and ACPA− of RA patients
Rheumatology International, 2011Anti-citrullinated protein/peptide antibodies (ACPA) have recently emerged as sensitive and specific serological markers of rheumatoid arthritis (RA), providing superior alternative of the rheumatoid factor (RF) test in the laboratory diagnostics of RA. We compare the change of serum RF, CRP, IgG, IgM, IgA, total complement, C3 and C4.
Chunhua, Xun, Yong, Zhao
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Pre-rheumatoid arthritis and ACPA: Contribution of ACPAs in the pathogeny of pre-disease stage
Joint Bone Spine, 2021Rheumatoid arthritis (RA) is a chronic auto-immune disease characterized by a breach in tolerance leading to joint inflammation. The underlying mechanism(s) triggering this breach is (are) still debated. However, a major advance in our knowledge of RA has been the identification of an abnormal auto-immunity directed against citrullinated peptides, and ...
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Annals of the Rheumatic Diseases, 2011
Very early therapy of rheumatoid arthritis (RA) with disease-modifying antirheumatic drugs is associated with lower levels of joint destruction and a higher chance of achieving remission.1,–,5 Having symptoms for >12 weeks at treatment initiation is a strong and independent risk factor for a persistent disease course.1 3,–,5 These observations have led
Willemze, A. +6 more
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Very early therapy of rheumatoid arthritis (RA) with disease-modifying antirheumatic drugs is associated with lower levels of joint destruction and a higher chance of achieving remission.1,–,5 Having symptoms for >12 weeks at treatment initiation is a strong and independent risk factor for a persistent disease course.1 3,–,5 These observations have led
Willemze, A. +6 more
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ACPA and Bone Loss in Rheumatoid Arthritis
Current Rheumatology Reports, 2013Rheumatoid arthritis (RA) is an autoimmune inflammatory disease characterized by bone loss. Degree of inflammation and autoantibody positivity have both been identified as important initiators of skeletal damage in RA. Whereas it is well appreciated that inflammation initiates bone loss via the action of cytokines, the effect of autoantibodies in ...
Georg Schett +2 more
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Annals of the Rheumatic Diseases, 2021
Clinically evident tenosynovitis can be seen in established rheumatoid arthritis (RA). Imaging research has recently shown that tenosynovitis at small joints occurs in early RA, contributes to typical RA symptoms (including joint swelling) and is infrequent in healthy controls.
Xanthe Marijn Edmée Matthijssen +4 more
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Clinically evident tenosynovitis can be seen in established rheumatoid arthritis (RA). Imaging research has recently shown that tenosynovitis at small joints occurs in early RA, contributes to typical RA symptoms (including joint swelling) and is infrequent in healthy controls.
Xanthe Marijn Edmée Matthijssen +4 more
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ACPA 2014 Oral Presentation Abstracts
The Cleft Palate Craniofacial Journal, 2014The abstracts below were presented as podium presentations at the 71(st) Annual Meeting of the American Cleft Palate-Craniofacial Association from March 24(th) to 29(th), 2014. They are printed directly as they appeared in the program book.
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ACPA 2017 Oral Presentation Abstracts
The Cleft Palate Craniofacial Journal, 2017The peer-reviewed abstracts presented at the 74th Annual Meeting of the ACPA are published as submitted by the authors. For financial conflict of interest disclosure, please visit http://meeting.acpa-cpf.org/disclosures.html.
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[Autoantibodies and the autoreactive immune response : There is more to ACPA than ACPA].
Zeitschrift fur Rheumatologie, 2020The immune response against posttranslationally modified (PTM) antigens, in particular the generation of anti-citrullinated protein antibodies (ACPA), is a very specific hallmark of rheumatoid arthritis. The factors that initiate this immune response and the triggers that stimulate the transition from asymptomatic autoimmunity to autoimmune disease are
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