C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi+5 more
wiley +1 more source
Acquired bronchoesophageal fistula
Bronchoesophageal fistula in an adult is rarely encountered in clinical practice. Most commonly, they have malignant origin. We report a case of bronchoesophageal fistula secondary to trauma caused by upper gastrointestinal endoscopy.
Aggarwal Deepak+2 more
doaj
Acquired versus Non-Acquired Subsidiaries - Which Entry Mode do Parent Firms Prefer [PDF]
Despite the economic importance of international foreign direct investment (FDI) flows, investment decisions of multinational firms are not well understood.
Esther Kalkbrenner
core
Cyclosporine treatment of acquired hemophilia due to factor VIII antibodies [PDF]
Acquired hemophilia, caused by autoantibodies against coagulation factor VIII, is usually treated with steroids, cyclophosphamide, intravenous gammaglobulins and sporadically other drugs.
Baele, Gaston+2 more
core
Time-resolved optical fluorescence spectroscopy of heterogeneous turbid media with special emphasis on brain tissue structures including diseased regions: A sensitivity analysis [PDF]
Fluorescence-enhanced optical imaging based on near-infrared light provides a promising tool to differentiate diseased lesions from normal tissue. However, the measurement sensitivity of the fluorescence signals acquired at the output surface of the ...
L'HUILLIER, Jean-Pierre+1 more
core +5 more sources
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile+8 more
wiley +1 more source
Large-Scale information extraction from textual definitions through deep syntactic and semantic analysis [PDF]
We present DEFIE, an approach to large-scale Information Extraction (IE) based on a syntactic-semantic analysis of textual definitions. Given a large corpus of definitions we leverage syntactic dependencies to reduce data sparsity, then ...
DELLI BOVI, CLAUDIO+2 more
core +1 more source
Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley +1 more source
Preventing Hospital Acquired Infections Through a Workflow-Based Cyber-Physical System
Hospital acquired infections (HAI) are infections acquired within the hospital from healthcare workers, patients or from the environment, but which have no connection to the initial reason for the patient's hospital admission.
Bocicor, Maria Iuliana+2 more
core +1 more source
Extending the Foundational Model of Anatomy with Automatically Acquired Spatial Relations [PDF]
Formal ontologies have made significant impact in bioscience over the last ten years. Among them, the Foundational Model of Anatomy Ontology (FMA) is the most comprehensive model for the spatio-structural representation of human anatomy.
Christian Folz+4 more
core +2 more sources