Results 101 to 110 of about 5,731,504 (362)
Cyclosporine treatment of acquired hemophilia due to factor VIII antibodies [PDF]
, 2000 Acquired hemophilia, caused by autoantibodies against coagulation factor VIII, is usually treated with steroids, cyclophosphamide, intravenous gammaglobulins and sporadically other drugs.
Baele, Gaston +2 more
core
Epigenetics as a mechanism driving polygenic clinical drug resistance [PDF]
, 2006 Aberrant methylation of CpG islands located at or near gene promoters is associated with inactivation of gene expression during tumour development.
A Balmain +57 more
core +2 more sources
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Kur’an’a Göre İnsana Değer Katan Unsurlar
Şırnak Üniversitesi İlahiyat Fakültesi Dergisi, 2020 Bu çalışmada insana değer katan unsurların tespiti ve vehbî-kesbî olmaları cihetinden tasnifi amaçlanmaktadır. İnsanın kıymeti kâinattaki ilahî işaretleri önemseyip önemsememesiyle doğru orantılıdır.
Cumhur Demirel
doaj +1 more source
Extending the Foundational Model of Anatomy with Automatically Acquired Spatial Relations [PDF]
, 2009 Formal ontologies have made significant impact in bioscience over the last ten years. Among them, the Foundational Model of Anatomy Ontology (FMA) is the most comprehensive model for the spatio-structural representation of human anatomy.
Christian Folz +4 more
core +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Frontiers in OncologyBackgroundThe differences in clinical characteristics and treatment prognosis in NSCLC patients harboring primary and acquired BRAF mutations are still poorly understood.MethodsFrom Oct 2017 to Dec 2023, 10, 211 lung cancer patients at Shanghai Ruijin ...
Xiangran Feng +27 more
doaj +1 more source
Counselling for people with sight loss in the UK: The need for provision and the need for evidence [PDF]
, 2010 For adults of any age the diagnosis of a visual impairment can be traumatic, and timely referral to informal peer support and/or professional counselling may be both beneficial and appropriate.
Gosney, M.A., Nyman, S.R., Victor, C.R.
core +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Acquired hemophilia A in a patient with advanced prostate cancer
Autopsy and Case Reports, 2015 Acquired hemophilia A (AHA) is a rare disorder that results from the presence of autoantibodies against the clotting factor VIII (FVIII) causing hemorrhagic disorders.
Daniel da Motta Girardi +6 more
doaj