Results 41 to 50 of about 513,528 (306)

Assessing the global variation in patient characteristics, management and short-term outcomes of spontaneous intracranial haemorrhage worldwide: a protocol for a global observational prospective multicentre study (the PLOT-ICH study)

BMJ Open
Introduction Stroke is the second leading cause of death worldwide, with the greatest burden in low- and middle-income countries (LMICs). Haemorrhagic stroke or spontaneous intracranial haemorrhage (sICH), including intraparenchymal haemorrhage (IPH) and
Kee B Park, Michael F Bath, David Clark, Angelos G Kolias, Peter J Hutchinson, Tom Bashford, Alexis Joannides, Michael Martin, Sara Venturini, Tariq Khan, Katharina Kohler, Anthony Figaji, Sami Tetri, Brandon George Smith, Charlotte Jane Whiffin, Rikin A Trivedi, Saniya Mediratta, Arina Tamborska, Deanna Saylor, Harry Mee, Nourou Dine Adeniran Bankole, Laura Hobbs, Karol Budohoski, Megan Still, Mohamed Amin Soliman, Elijah Katambo, Tommi K Korhonen, Nicephorus Rutabasibwa, Arnold Bhebhe, Thangaraj Munusamy, Abenezer Tirsit, Petra Wahjoepramono, Almas Fasih Khattak   +32 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Brain-In-Hand technology for adults with acquired brain injury: A convergence of mixed methods findings

Journal of Rehabilitation and Assistive Technologies Engineering, 2022
Introduction Individuals with acquired brain injury may find it difficult to self-manage and live independently. Brain-in-Hand is a smartphone app designed to support psychological problems and encourage behaviour change, comprised of a structured diary,
Jade Kettlewell, Asha Ward, Roshan das Nair, Kate Radford   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Neurophysiological predictors of full clinical consciousness recovery in patients with DoC: a retrospective evaluation of the DoC-NP Score

Frontiers in Neurology
BackgroundPrognostication in prolonged disorders of consciousness (pDoC) remains challenging, particularly when estimating recovery of a clinically observable conscious state.
Valerio Sveva, Valerio Sveva, Ilaria Sermasi, Valentina Colombo, Francesca Cesira Cava, Bledi Shehaj, Alice Rita Portillo, Chiara Minardi, Matteo Bologna, Matteo Bologna, Paola Rucci, Pamela Salucci   +11 more
doaj   +1 more source

Evidence-based practice ‘on-the-go’: using ViaTherapy as a tool to enhance clinical decision making in upper limb rehabilitation after stroke, a quality improvement initiative

BMJ Open Quality, 2019
Recovery of upper limb function after stroke is currently sub-optimal, despite good quality evidence showing that interventions enabling repetitive practice of task-specific activity are effective in improving function.
Mark Bayley, Nicola J Hancock, Kathryn Collins, Charlie Dorer, Steven L Wolf, Valerie M Pomeroy   +5 more
doaj   +1 more source

Sensory Stimulation of the Foot and Ankle Early Post-stroke: A Pilot and Feasibility Study

Frontiers in Neurology, 2021
Background: Somatosensory stimulation of the lower extremity could improve motor recovery and walking post-stroke. This pilot study investigated the feasibility of a subsequent randomized controlled trial (RCT) to determine whether task-specific gait ...
Alison M. Aries, Valerie M. Pomeroy, Valerie M. Pomeroy, Julius Sim, Susan Read, Susan M. Hunter   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The global state of cranioplasty practice following cranial decompression for traumatic brain injury: a provider survey

World Neurosurgery: X
Objective: For patients undergoing decompressive craniectomy for TBI, cranioplasty facilitates rehabilitation and reintegration into society. Cranioplasty practice is poorly documented globally. Challenges including lack of materials and technical skills
Sara Venturini, Saniya Mediratta, Tobias J. Adams, Harry Mee, Bhagavatula Indira Devi, Tariq Khan, Andres M. Rubiano, Franco Servadei, Adel Helmy, Angelos Kolias, Peter J. Hutchinson   +10 more
doaj   +1 more source

Impaired Cerebral Autoregulation during Head Up Tilt in Patients with Severe Brain Injury. [PDF]

PLoS ONE, 2016
Early mobilization is of importance for improving long-term outcome for patients after severe acquired brain injury. A limiting factor for early mobilization by head-up tilt is orthostatic intolerance.
Christian Gunge Riberholt, Niels Damkjær Olesen, Mira Thing, Carsten Bogh Juhl, Jesper Mehlsen, Tue Hvass Petersen   +5 more
doaj   +1 more source