Results 51 to 60 of about 513,528 (306)

Back to School: Academic Functioning and Educational Needs among Youth with Acquired Brain Injury

Children, 2022
Youth with a history of traumatic or non-traumatic acquired brain injury are at increased risk for long-lasting cognitive, emotional, behavioral, social, and physical sequelae post-injury.
W. Michael Vanderlind, Lauren A. Demers, Georgina Engelson, Rollen C. Fowler, Melissa McCart   +4 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Methodological issues in the design and evaluation of supported communication for aphasia training: a cluster-controlled feasibility study

BMJ Open, 2016
Objective To assess the feasibility and acceptability of training stroke service staff to provide supported communication for people with moderate–severe aphasia in the acute phase; assess the suitability of outcome measures; collect data to inform ...
Allan Clark, Garry Barton, Valerie M Pomeroy, Kathleen Lane, Simon Horton   +4 more
doaj   +1 more source

Sensorimotor vs. Motor Upper Limb Therapy for Patients With Motor and Somatosensory Deficits: A Randomized Controlled Trial in the Early Rehabilitation Phase After Stroke

Frontiers in Neurology, 2020
Background: Somatosensory function plays an important role in motor learning. More than half of the stroke patients have somatosensory impairments in the upper limb, which could hamper recovery.Question: Is sensorimotor upper limb (UL) therapy of more ...
Nele De Bruyn, Leen Saenen, Liselot Thijs, Annick Van Gils, Eva Ceulemans, Bea Essers, Christophe Lafosse, Marc Michielsen, Hilde Beyens, Fabienne Schillebeeckx, Kaat Alaerts, Geert Verheyden   +11 more
doaj   +1 more source

Exploring the intersection of brain injury and mental health in survivors of intimate partner violence: A scoping review

Frontiers in Public Health, 2023
RationaleIntimate partner violence (IPV) is the most commonly occurring form of violence against women. The most common site of injury in IPV is the head, face, and neck, resulting in possible brain injury (BI). Independently, mental health (MH) concerns
Danielle Toccalino, Danielle Toccalino, Amy Moore, Elizabeth Cripps, Sophia Chuon Gutierrez, Angela Colantonio, Angela Colantonio, Angela Colantonio, Angela Colantonio, Angela Colantonio, Christine M. Wickens, Christine M. Wickens, Christine M. Wickens, Christine M. Wickens, Christine M. Wickens, Vincy Chan, Vincy Chan, Vincy Chan, Vincy Chan, Emily Nalder, Emily Nalder, Emily Nalder, Halina (Lin) Haag, Halina (Lin) Haag   +23 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Characterizing the evolution of oculomotor and vestibulo-ocular function over time in children and adolescents after a mild traumatic brain injury

Frontiers in Neurology, 2022
BackgroundImpairments to oculomotor (OM) and vestibulo-ocular reflex (VOR) function following pediatric mTBI have been demonstrated but are poorly understood.
Adrienne Crampton, Kathryn J. Schneider, Kathryn J. Schneider, Kathryn J. Schneider, Lisa Grilli, Mathilde Chevignard, Mathilde Chevignard, Mathilde Chevignard, Michal Katz-Leurer, Miriam H. Beauchamp, Miriam H. Beauchamp, Chantel Debert, Isabelle J. Gagnon, Isabelle J. Gagnon   +13 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

A Protocol to Understand the Implementation and Experiences of an Online Community-Based Performance Arts Programme Through and Beyond the COVID-19 Pandemic, Brain Waves

Frontiers in Rehabilitation Sciences, 2022
IntroductionIndividuals living with acquired brain injury experience numerous psychological, physical, and social challenges. Since the COVID-19 pandemic, many have experienced additional isolation, mental health issues and have had limited access to ...
Carolina Estevao, Elizabeth Taylor, Lucinda Jarrett, Joseph Fort, Kevin Murphy, Anthony Woods, Nikki Crane, Daisy Fancourt, Carmine M. Pariante, Fiona Jones   +9 more
doaj   +1 more source