Results 71 to 80 of about 9,561 (186)

CBP/β‐Catenin Signaling in Hepatocytes Plays Pivotal Roles in MMP‐7‐Mediated Liver Fibrosis in a Metabolic Dysfunction‐Associated Steatohepatitis Mouse Model

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
CDAHFD‐induced hepatic steatosis stimulates CBP/β‐catenin signaling in hepatocytes, leading to increased production of the downstream effector MMP‐7. Hepatocyte‐derived MMP‐7 contributes to fibrogenic responses and is associated with the progression of liver fibrosis.
Jun Imamura, Masamichi Kimura, Yumi Otoyama, Koji Nishikawa, Michinori Kohara, Kiminori Kimura   +5 more
wiley   +1 more source

Acquired hemophilia.

Haematologica, 1995
Acquired hemophilia is a very rare disease characterized by the presence of an autoantibody (mainly IgG) to factor VIII, with a clinical presentation resembling hemophilia A. It is associated with various autoimmune or dermatologic diseases, pregnancy, cancer, or drug ingestion, but in almost 50% of patients no underlying disorder is found.
P, Bouvry, P, Recloux
openaire   +1 more source

Dual‐Functional Polyphosphoesters for Gene Delivery: Synergistic Effects of Guanidinium and Hydrophobic Side Chains in Degradable Polymers

Advanced Healthcare Materials, Volume 15, Issue 9, 6 March 2026.
This study presents guanidinium‐ and indole‐functionalized polyphosphoesters as degradable, non‐viral gene delivery vectors. Through precise tuning of charge density and hydrophobicity, these polymers form stable polyplexes with low toxicity. Remarkably, minor structural changes yield up to 200‐fold differences in transfection efficiency, highlighting ...
Markus Kötzsche, Andreas Dzierza, Jan Egger, Timo Rheinberger, Christin Weilandt, Frederik R. Wurm, Ivo Nischang, Dagmar Fischer, Kalina Peneva   +8 more
wiley   +1 more source

Challenges facing community-dwelling adults with hemophilia: Implications for community-based adult education and nursing

Journal of International Medical Research, 2020
Community-dwelling adults are members of society residing in community settings. Community-based adult education is designed for local residents and groups, to enable them to improve their quality of life within their community.
Charity Chinelo Okide, Chiedu Eseadi, Uzoamaka Lucynda Koledoye, Felicia Mbagwu, Nwakaego Ebele Ekwealor, Nkechi Mercy Okeke, Chioma Osilike, Polycarp M.D. Okeke   +7 more
doaj   +1 more source

Factor XIII Deficiency: A Silent Bleeder Behind a Normal Coagulation Profile

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Factor XIII deficiency is a rare cause of bleeding disorder. An 8‐month‐old male infant presented with persistent bleeding from a minor lip cut injury, which was sustained 2 days prior. The bleeding did not stop despite local hemostatic measures.
Ramesh Yadav, Madhav Raj Karki, Dikshya Pokhrel, Aron Neupane, Kshitiz Parajuli, Hem Sagar Rimal   +5 more
wiley   +1 more source

Patients' Associations as Co‐Creators of Knowledge: Insights From a Community‐Based Participatory Research Study (ProSafe Project)

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background and Aims Patient and public involvement and engagement (PPIE) in research is crucial for producing knowledge that is meaningful to the participating community. Sharing PPIE principles into practical tools and strategies enriches the development of participatory research methodologies.
Francesca Moretti, Silvia Colpo, Sara Montresor, Daniela Facchinello, Raffaella Robello, Mariangela Mazzi, Stefano Tardivo, Lisa Stagi, Luisa De Stefano, Andrea Zotti, Luigi Ambroso, Cristina Destro, Salvo Leone, Davide Petruzzelli, Ugo Moretti, Michela Rimondini   +15 more
wiley   +1 more source

Companion Diagnostics in Clinical Therapy: Current Applications and Future Directions

MedComm, Volume 7, Issue 3, March 2026.
Companion diagnostics use biomarker‐based assays to stratify patients for precision therapies, improving outcomes while reducing ineffective treatment and side effects. This review summarizes the evolution, regulatory landscape, clinical applications, and technological platforms of CDx, highlighting their role in biomarker‐driven precision therapy.
Yuesong Wu, Rou Xue, Xiangwen Luo, Jiangnan Liao, Zongbo Zhang, Jinhai Deng, Teng Liu, Xin Li, Zhe‐Sheng Chen, Mingzhu Yin   +9 more
wiley   +1 more source

Acquired Hemophilia A successfully treated with rituximab

Mediterranean Journal of Hematology and Infectious Diseases, 2015
Acquired hemophilia A (AHA) is a rare bleeding disorder due to the development of specific autoantibodies against factor VIII. The anti-CD20 monoclonal antibody Rituximab has been proven to be effective in  obtaining a long-term suppression of inhibitors
Giovanni D'Arena, Elvira Grandone, Matteo Nicola Dario Di Minno, Pellegrino Musto, Giovanni Di Minno   +4 more
doaj   +1 more source

Acceptability and Determinants for Implementation of the EnzySystem, a Novel Near‐Patient Testing Platform for Haemophilia A

Haemophilia, Volume 32, Issue 2, Page 481-489, March/April 2026.
ABSTRACT Introduction Coagulation testing in haemophilia A is limited by the scarcity of testing facilities capable of performing relevant assays. This issue incentivized the development of the EnzySystem for haemophilia A, a near‐patient testing platform aimed to measure Factor VIII activity and thrombin generation simultaneously within 1 h from 100 ...
Aernoud P. Bavinck, Kyle Davis, Lisa van Engelshoven, Monique G. van Lier, Tanja Hamacher, Nicole M. A. Blijlevens, Amy Shapiro, Saskia E. M. Schols, Waander L. van Heerde   +8 more
wiley   +1 more source

Low‐Load Quadriceps Strengthening With Blood Flow Restriction in Adults With Haemophilic Knee Arthropathy: A Randomised Controlled Trial

Haemophilia, Volume 32, Issue 2, Page 522-533, March/April 2026.
Abstract Introduction Haemophilic knee arthropathy leads to a reduction in muscle mass and strength. Blood flow restriction (BFR) involves the application of a compressive cuff that enables strength training with reduced loads. Objective To evaluate safety as the primary outcome and the efficacy (muscle strength and activation, functional capacity and ...
Mar Villalón‐González, Raúl Pérez‐Llanes, José Antonio López‐Pina, Rubén Cuesta‐Barriuso, Elena Donoso‐Úbeda   +4 more
wiley   +1 more source