Results 141 to 150 of about 2,306,835 (372)

Why Doesn’t a Pregnant Woman Reject her Fetus [PDF]

open access: yes, 2011
Overview: Recurrent Pregnancy loss (RPL) occurs when a woman has three or more consecutive miscarriages; this phenomenon happens in about 1-3% of women. Why some women reject their unborn fetus and others carry theirs to term is still unclear.
Merry, Lisa
core   +1 more source

How Exposures to Biologics Influence the Induction and Incidence of Asthma [PDF]

open access: yes, 2006
A number of environmental factors can affect the development and severity of allergy and asthma; however, it can be argued that the most significant inhaled agents that modulate the development of these conditions are biologics.
Bauer O   +12 more
core   +4 more sources

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

open access: yesMolecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran   +16 more
wiley   +1 more source

Mathematical models for vaccination, waning immunity and immune system boosting: a general framework [PDF]

open access: yesarXiv, 2015
When the body gets infected by a pathogen or receives a vaccine dose, the immune system develops pathogen-specific immunity. Induced immunity decays in time and years after recovery/vaccination the host might become susceptible again. Exposure to the pathogen in the environment boosts the immune system thus prolonging the duration of the protection ...
arxiv  

Impact of molecular diagnostics and targeted cancer therapy on patient outcomes (MODIFY): a retrospective study of the implementation of precision oncology

open access: yesMolecular Oncology, EarlyView.
The authors conducted a retrospective study of 94 patients with advanced cancer who underwent next‐generation sequencing (NGS) gene panel analysis and received targeted treatments when applicable. Results further support evidence indicating that molecular profiling provides clinical benefit.
Michaël Dang   +3 more
wiley   +1 more source

Symbiont-induced odorant binding proteins mediate insect host hematopoiesis

open access: yeseLife, 2017
Symbiotic bacteria assist in maintaining homeostasis of the animal immune system. However, the molecular mechanisms that underlie symbiont-mediated host immunity are largely unknown.
Joshua B Benoit   +7 more
doaj   +1 more source

Towards a Conceptual Framework for Innate Immunity [PDF]

open access: yesProceedings of the 4th International Conference on Artificial Immune Systems (ICARIS 2005), Lecture Notes in Computer Science 3627, Banff, Canada, p 112-125, 2010
Innate immunity now occupies a central role in immunology. However, artificial immune system models have largely been inspired by adaptive not innate immunity. This paper reviews the biological principles and properties of innate immunity and, adopting a conceptual framework, asks how these can be incorporated into artificial models.
arxiv  

The evolution of resistance through costly acquired immunity [PDF]

open access: yes, 2004
We examine the evolutionary dynamics of resistance to parasites through acquired immunity. Resistance can be achieved through the innate mechanisms of avoidance of infection and reduced pathogenicity once infected, through recovery from infection and ...
Boots M., Michael Boots, Roger G. Bowers
core   +2 more sources

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu   +7 more
wiley   +1 more source

Forward: The Legal Challenge of Aids [PDF]

open access: yes, 1988
The sudden outbreak of Acquired Immune Deficiency Syndrome (AIDS) during the first half of the 1980s has generated major challenges to our system of government and ...
Leonard, Arthur S.
core   +1 more source

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