Results 151 to 160 of about 2,306,835 (372)
Molecular Oncology, EarlyView.CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar +4 more
wiley +1 more source
COVID-19 vaccines for moderately to severely immunocompromised people [PDF]
Updated Apr. 12, 2022Having a weakened immune system can make you more likely to get severely ill from COVID-19. Many conditions and treatments can cause a person to be immunocompromised or have a weakened immune system.
core +6 more sources
Two novel immunization strategies for epidemic control in directed scale-free networks with nonlinear infectivity [PDF]
arXiv, 2018 In this paper, we propose two novel immunization strategies, i.e., combined immunization and duplex immunization, for SIS model in directed scale-free networks, and obtain the epidemic thresholds for them with linear and nonlinear infectivities. With the suggested two new strategies, the epidemic thresholds after immunization are greatly increased. For
arxiv
Molecular Oncology, EarlyView.Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy +12 more
wiley +1 more source
Primary extranodal diffuse large B‐cell lymphoma: Molecular features, treatment, and prognosis
Aging and Cancer, Volume 3, Issue 3-4, Page 133-146, September-December 2022., 2022 One‐third of DLBCL arises from extranodal organs and is challenging to manage. Molecular features are critical to elucidate the differences in clinical features, predict the disease prognosis, and improve effective targeted therapeutic strategies. Abstract Diffuse large B‐cell lymphoma (DLBCL) is the most common subtype of non‐Hodgkin's lymphoma and ...
Si‐Yuan Chen +3 more
wiley +1 more source
Analiz Riska Zdorovʹû, 2017 Our task was to create a mathematical model which could describe anti-virus immune response regulation allowing for disorders in the adaptation (neuroendocrine and immune) systems caused by chemical factors of various genesis. We analyzed immune response
P.V. Trusov +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Transient receptor potential melastatin‐4 (TRPM4) is overexpressed in prostate cancer (PCa). Knockout of TRPM4 resulted in reduced PCa tumor spheroid size and decreased PCa tumor spheroid outgrowth. In addition, lack of TRPM4 increased cell death in PCa tumor spheroids.
Florian Bochen +6 more
wiley +1 more source
JTO Clinical and Research Reports, 2020 Introduction: Immune-related adverse events affecting virtually every organ system have been described in individuals receiving immune checkpoint inhibitors.
Jacinth J. Joseph, MD +4 more
doaj
Immuno-epidemiology of a population structured by immune status: a mathematical study of waning immunity and immune system boosting [PDF]
arXiv, 2014 When the body gets infected by a pathogen the immune system develops pathogen-specific immunity. Induced immunity decays in time and years after recovery the host might become susceptible again. Exposure to the pathogen in the environment boosts the immune system thus prolonging the time in which a recovered individual is immune.
arxiv
Molecular Oncology, EarlyView.Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti +8 more
wiley +1 more source