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Acquired TTP: ADAMTS13 meets the immune system

Blood Reviews, 2014
The majority of the patients affected by acquired thrombotic thrombocytopenic purpura (TTP) develop autoantibodies directed towards ADAMTS13 that interfere with its von Willebrand Factor (VWF) processing activity. B cell responses have been shown to primarily target the spacer domain of ADAMTS13 thereby prohibiting the binding of ADAMTS13 to the VWF A2
Fabian C, Verbij   +3 more
openaire   +3 more sources

Acquired Immunity to Systemic Candidiasis in Immunodeficient Mice

Journal of Infectious Diseases, 1991
Twenty-seven percent of beige-athymic (bg/bg nu/nu) mice died of systemic candidiasis 7-20 weeks after gastrointestinal tract colonization with Candida albicans. Conversely, beige-euthymic (bg/bg nu/+) mice colonized with C. albicans for a similar time period did not die or develop systemic candidiasis. C. albicans-colonized bg/bg nu/+ mice, but not bg/
M T, Cantorna, E, Balish
openaire   +2 more sources

Regulation of Acquired Immune System by Notch Signaling

International Journal of Hematology, 2005
T- and B-cells are generated from hematopoietic stem cells through lymphoid intermediates. The interplay of intrinsic and extrinsic signals determines cell fate at the branch point for T- and B-cell lineages and at the post-commitment stage of lymphogenesis.
Yoshiaki, Minato, Koji, Yasutomo
openaire   +2 more sources

Systemic and Acquired Immune Responses in Alzheimer's Disease

2007
Alzheimer's disease (AD) is a neurodegenerative disorder characterized clinically by a progressive cognitive decline and dementia. AD brains are marked by amyloid plaques and neurofibrillary tangles, neuronal cell loss, and a prominent activation of glial cells, and innate immune responses.
Markus, Britschgi, Tony, Wyss-Coray
openaire   +2 more sources

Systemic sarcocystosis in a patient with acquired immune deficiency syndrome

Human Pathology, 2008
Sarcocystis sp is a tissue coccidian parasite in humans that causes intestinal and muscular sarcocystosis in immunocompetent patients. Intestinal sarcocystosis can be diagnosed at the tissue level in the lamina propria of the small bowel and by fecal examination. Muscular sarcocystosis is diagnosed by microscopic examination of muscle biopsies.
Jorge N, Velásquez   +7 more
openaire   +2 more sources

Acquired Immune Deficiency Syndrome and the Developing Nervous System

1990
Publisher Summary The study of AIDS has contributed substantially to a growing awareness of the relationship between the immune and nervous systems. This chapter discusses a comparison of the impairments in the nervous and immune systems that arise from HIV infection.
D E, Brenneman, S K, McCune, I, Gozes
openaire   +2 more sources

Innate and Acquired Immunity in Real Time Systems

Fourth International Conference on Hybrid Intelligent Systems (HIS'04), 2005
In most potential industrial applications of artificial immune systems for early fault detection, some form of simple fault detection system already exists. We propose that this existing layer of simple, generally rule-based fault detection is analogous to innate immunity in the natural immune system. We argue that the artificial acquired immune system
D.W. Taylor, D.W. Corne
openaire   +1 more source

Acquired Immune Deficiency Syndrome and Systemic Lupus Erythematosis

Annals of Plastic Surgery, 2008
Compartment Syndrome (CS) is a disease that has 2 etiologies, that of acute events and that of chronic. It occurs when the pressure in a fascia-encased compartment exceeds the profusion pressure in tissue. The end result, when left untreated, is muscle and nerve ischemia that can cause significant morbidity.
Johnny J, Wirth   +3 more
openaire   +2 more sources

Central nervous system involvement in patients with acquired immune deficiency syndrome (AIDS)

Acta Neurologica Scandinavica, 2009
Central nervous system involvement occurred in 28 of 121 patients with acquired immune deficiency syndrome (AIDS). The major risk factor in this AIDS population was intravenous drug abuse (64%). A neurologic symptom or disability was the principal reason for hospitalization in 16 cases (57%).
B S, Koppel   +5 more
openaire   +2 more sources

Why did the acquired immune system of vertebrates evolve?

Developmental & Comparative Immunology, 2007
Rapidly expanding genomic information offers important insights into the mechanisms of acquired immunity and has fostered progress in comparative immunology. However, the question of why the acquired immune system, a trait restricted to jawed vertebrates, evolved has rarely been addressed.
openaire   +2 more sources

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