Cu,Zn superoxide dismutase genes in Tribolium castaneum: evolution, molecular characterisation and gene expression during immune priming. [PDF]
, 2017 The production of reactive oxygen species (ROS) is a normal consequence of the aerobic cell metabolism. Despite their high and potentially detrimental reactivity with various biomolecules, the endogenous production of ROS is a vital part of physiological,
Bakiu, Rigers +5 more
core +2 more sources
Post-translational modifications of proteins in tumor immunotherapy and their potential as immunotherapeutic targets [PDF]
Cellular, Molecular and Biomedical Reports, 2023 Protein is an important component of life. Protein modification after translation enriches the diversity of protein, regulates the structure and function of a protein, and participates in more life processes.
Yang Yang +2 more
doaj +1 more source
Dynamic interplay between tumour, stroma and immune system can drive or prevent tumour progression [PDF]
Converg. Sci. Phys. Oncol. 3 034002, 2017, 2017 In the tumour microenvironment, cancer cells directly interact with both the immune system and the stroma. It is firmly established that the immune system, historically believed to be a major part of the body's defence against tumour progression, can be reprogrammed by tumour cells to be ineffective, inactivated, or even acquire tumour promoting ...
arxiv +1 more source
Characterization of CRISPR-Cas Systems in Serratia marcescens Isolated from Rhynchophorus ferrugineus (Olivier, 1790) (Coleoptera: Curculionidae) [PDF]
, 2019 The CRISPR-Cas adaptive immune system has been attracting increasing scientific interest for biological functions and biotechnological applications. Data on the Serratia marcescens system are scarce.
Calia, Carla +7 more
core +1 more source
Getting on in Old Age: How the Gut Microbiota Interferes With Brain Innate Immunity
Frontiers in Cellular Neuroscience, 2021 The immune system is crucial for defending against various invaders, such as pathogens, cancer cells or misfolded proteins. With increasing age, the diminishing immune response, known as immunosenescence, becomes evident.
Omar Mossad, Omar Mossad, Thomas Blank
doaj +1 more source
Understanding how T helper cells learn to coordinate effective immune responses through the lens of reinforcement learning [PDF]
Phys. Rev. Research 3, 013222 (2021), 2019 The adaptive immune system of vertebrates can detect, respond to, and memorize diverse pathogens from past experience. While the clonal selection of T helper (Th) cells is the simple and established mechanism to better recognize new pathogens, the question that still remains unexplored is how the Th cells can acquire better ways to bias the responses ...
arxiv +1 more source
Trogocytosis by Entamoeba histolytica Mediates Acquisition and Display of Human Cell Membrane Proteins and Evasion of Lysis by Human Serum. [PDF]
, 2019 We previously showed that Entamoeba histolytica kills human cells through a mechanism that we termed trogocytosis ("trogo-" means "nibble"), due to its resemblance to trogocytosis in other organisms. In microbial eukaryotes like E.
Miller, Hannah W +2 more
core +1 more source
The Tumor Microenvironment Factors That Promote Resistance to Immune Checkpoint Blockade Therapy
Frontiers in Oncology, 2021 Through genetic and epigenetic alterations, cancer cells present the immune system with a diversity of antigens or neoantigens, which the organism must distinguish from self.
Bonnie L. Russell +5 more
doaj +1 more source
Diversity of immune strategies explained by adaptation to pathogen statistics [PDF]
Proc Natl Acad Sci USA 113(31) 8630 (2016), 2015 Biological organisms have evolved a wide range of immune mechanisms to defend themselves against pathogens. Beyond molecular details, these mechanisms differ in how protection is acquired, processed and passed on to subsequent generations -- differences that may be essential to long-term survival.
arxiv +1 more source
Beyond Vaccination Rates: A Synthetic Random Proxy Metric of Total SARS-CoV-2 Immunity Seroprevalence in the Community [PDF]
arXiv, 2022 Explicit knowledge of total community-level immune seroprevalence is critical to developing policies to mitigate the social and clinical impact of SARS-CoV-2. Publicly available vaccination data are frequently cited as a proxy for population immunity, but this metric ignores the effects of naturally-acquired immunity, which varies broadly throughout ...
arxiv