Clinical‐Stage Nanatinostat Triggers Productive Epstein‐Barr Virus Lytic Replication
ABSTRACT A phase 1b/2 study of the all‐oral “kick‐and‐kill” combo nanatinostat + valganciclovir (nana‐val) showed a ~40% overall response rate in patients with relapsed/refractory Epstein‐Barr virus (EBV)‐associated lymphomas. Despite the promising results in these difficult‐to‐treat cancers, there is little known about the effects of nanatinostat on ...
Ibukun A. Akinyemi +6 more
wiley +1 more source
From Oral Candidiasis to Candidemia: A Review of Superficial to Invasive Progression
Recent and limited evidence indicates that oral candidiasis can disseminate Candida albicans throughout the body, leading to invasive candidiasis, such as candidemia, a life‐threatening infection. Considering antifungal resistance and global outbreaks of emergent non‐albicans Candida and related yeasts, murine models help understand dissemination ...
Julia Robledo Jerez +3 more
wiley +1 more source
Secondary hemophagocytic syndrome in an acquired immunodeficiency syndrome and Alpha-thalassemia patient infected with Talaromyces marneffei: A case report and literature review. [PDF]
Wu Q +6 more
europepmc +1 more source
Mycobacterium tuberculosis–host interactions and infection outcomes. Following initial infection, alveolar macrophages phagocytose the pathogen, prompting the recruitment of innate immune cells including neutrophils, NK cells, and interstitial macrophages.
Xiaojuan Zhang +3 more
wiley +1 more source
Abstract A 1‐year‐old, female, spayed, mixed‐breed dog was examined by a referring veterinarian for a 1‐week history of sneezing, bilateral mucoid nasal discharge, mild bilateral ocular discharge and stertor. During rhinoscopy, a plant awn foreign body was removed, but upper respiratory signs persisted. Computed tomography of the head revealed findings
Glynn Woods +4 more
wiley +1 more source
Maternal and Newborn Outcomes of SARS-CoV-2/COVID-19 and Pregnancy: Parallels and Contrasts with Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome. [PDF]
Li D +4 more
europepmc +1 more source
Abstract Background and aims Evidence on the causal impact and corresponding risk relationships between dimensions of alcohol consumption and health outcomes continues to evolve, with some contradictory findings across study designs. This review aimed to update current knowledge on causality and risk relationships to inform global and national ...
Sinclair Carr +5 more
wiley +1 more source
Infection control in the brain and the eye
Abstract The Central Nervous System (CNS), comprising the brain and the eye, is considered to have a ‘privileged’ mechanism for dealing with immunological challenge (immune privilege, IP). CNS IP has been revealed through experiments using foreign protein antigens and cell and tissue alloantigens (grafts), but evidence for a role for IP in modulating ...
John V. Forrester +2 more
wiley +1 more source
Optimal Timing of Antiretroviral Therapy Initiation in Acquired Immunodeficiency Syndrome-Associated Toxoplasmic Encephalitis: A Prospective Observational Multicenter Study in China. [PDF]
Li Y +9 more
europepmc +1 more source
This study provides real‐world evidence that implementing an advanced therapy care pathway for patients with IBD leads to significant healthcare cost savings without compromising quality of life. These findings support broader implementation of care pathways in the management of patients with chronic conditions to optimise care delivery and resource ...
Elyke H. Visser +12 more
wiley +1 more source

