Results 11 to 20 of about 185,841 (304)

Altered lipid metabolites accelerate early dysfunction of T cells in HIV-infected rapid progressors by impairing mitochondrial function

Frontiers in Immunology, 2023
The complex mechanism of immune-system damage in HIV infection is incompletely understood. HIV-infected “rapid progressors” (RPs) have severe damage to the immune system early in HIV infection, which provides a “magnified” opportunity to study the ...
Si-Yao Li, Si-Yao Li, Si-Yao Li, Lin-Bo Yin, Lin-Bo Yin, Lin-Bo Yin, Hai-Bo Ding, Hai-Bo Ding, Hai-Bo Ding, Mei Liu, Mei Liu, Jun-Nan Lv, Jun-Nan Lv, Jun-Nan Lv, Jia-Qi Li, Jia-Qi Li, Jia-Qi Li, Jing Wang, Jing Wang, Jing Wang, Tian Tang, Tian Tang, Tian Tang, Ya-Jing Fu, Ya-Jing Fu, Ya-Jing Fu, Yong-Jun Jiang, Yong-Jun Jiang, Yong-Jun Jiang, Zi-Ning Zhang, Zi-Ning Zhang, Zi-Ning Zhang, Hong Shang, Hong Shang, Hong Shang   +34 more
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Prevalence and associated factors of depression and anxiety among patients with cancer seeking treatment at the Butaro Cancer Center of Excellence in Rwanda

Frontiers in Public Health, 2023
BackgroundDepression and anxiety are psychological and physiological disturbances persisting in cancer patients with high prevalence worldwide, particularly in low- and middle-income countries, due to complexities of determinants of health including ...
Samuel Habimana, Samuel Habimana, Emmanuel Biracyaza, Emmanuel Biracyaza, Tharcisse Mpunga, Epaphrodite Nsabimana, Florence Kayitesi, Pascal Nzamwita, Stefan Jansen   +8 more
doaj   +1 more source

Antiretroviral treatment interruption and resumption within 16 weeks among HIV-positive adults in Jinan, China: a retrospective cohort study

Frontiers in Public Health, 2023
BackgroundTreatment interruption has been found to increase the risk of opportunistic infections and death among HIV-positive adults, posing a challenge to fully realizing antiretroviral therapy (ART).
Jing Ma, Yan Jin, Kedi Jiao, Yao Wang, Lijie Gao, Xinrui Li, Wei Ma   +6 more
doaj   +1 more source

Vitamin D and Calcium Supplementation Reverses Tenofovir-Caused Bone Mineral Density Loss in People Taking ART or PrEP: A Systematic Review and Meta-Analysis

Frontiers in Nutrition, 2022
BackgroundThe decrease of bone mineral density (BMD) after the intake of Tenofovir disoproxil fumarate (TDF)-based drugs in people living with HIV/AIDS (PLWHA) and HIV-negative key populations under pre-exposure prophylaxis (PrEP) regimen raised concerns.
Xiaoyan Bi, Xiaoyan Bi, Xiaoyan Bi, Xiaoyan Bi, Fan Liu, Fan Liu, Fan Liu, Fan Liu, Xiangjun Zhang, Hongyi Wang, Hongyi Wang, Hongyi Wang, Hongyi Wang, Zehao Ye, Zehao Ye, Zehao Ye, Zehao Ye, Ke Yun, Ke Yun, Ke Yun, Ke Yun, Xiaojie Huang, Haibo Ding, Haibo Ding, Haibo Ding, Haibo Ding, Wenqing Geng, Wenqing Geng, Wenqing Geng, Wenqing Geng, Junjie Xu, Junjie Xu, Junjie Xu, Junjie Xu, Junjie Xu   +34 more
doaj   +1 more source

High-Throughput Screening and Identification of Human Adenovirus Type 5 Inhibitors

Frontiers in Cellular and Infection Microbiology, 2021
Human adenovirus infections can develop into diffuse multi-organ diseases in young children and immunocompromised patients, and severe cases can lead to death. However, there are no approved antiviral drugs available to treat adenovirus diseases. In this
Xiaojing Wen, Xiaojing Wen, Xiaojing Wen, Li Zhang, Shan Zhao, Qiang Liu, Wenyi Guan, Jiajing Wu, Qiwei Zhang, Qiwei Zhang, Hongling Wen, Hongling Wen, Weijin Huang   +12 more
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Medication Non-adherence and Condomless Anal Intercourse Increased Substantially During the COVID-19 Pandemic Among MSM PrEP Users: A Retrospective Cohort Study in Four Chinese Metropolises

Frontiers in Medicine, 2022
BackgroundThe coronavirus disease (COVID-19) pandemic has impacted HIV prevention strategies globally. However, changes in pre-exposure prophylaxis (PrEP) adherence and HIV-related behaviors, and their associations with medication adherence among men who
Yangyang Gao, Yangyang Gao, Yangyang Gao, Yangyang Gao, Qinghai Hu, Qinghai Hu, Qinghai Hu, Qinghai Hu, Sequoia I. Leuba, Le Jia, Le Jia, Le Jia, Le Jia, Hongyi Wang, Hongyi Wang, Hongyi Wang, Hongyi Wang, Xiaojie Huang, Yaokai Chen, Hui Wang, Jing Zhang, Jing Zhang, Jing Zhang, Jing Zhang, Zhenxing Chu, Zhenxing Chu, Zhenxing Chu, Zhenxing Chu, Lukun Zhang, Zixin Wang, Hong Shang, Hong Shang, Hong Shang, Hong Shang, Junjie Xu, Junjie Xu, Junjie Xu, Junjie Xu, CROPrEP Study Team, Xiaoqing He, Yao Li, Fang Zhao, Yijun Duan, Rui Li, Shangcao Li, Hang Li, Zhili Hu, Rantong Bao, Sitong Cui, Zhaozhen Liu, Zehao Ye, Xiaoyun Shi   +51 more
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Chinese Guidelines for Diagnosis and Treatment of Human Immunodeficiency Virus Infection/Acquired Immunodeficiency Syndrome(2021 edition)

Xiehe Yixue Zazhi, 2022
In 2005, the first edition of the guidelines for the diagnosis and treatment of acquired immunodeficiency syndrome(AIDS) was formulated by the AIDS Professional Group of the Society of Infectious Diseases of Chinese Medical Association, which was updated
Acquired Immunodeficiency Syndrome and Hepatitis C Professional Group, Society of Infectious Diseases, Chinese Medical Association, Chinese Center for Disease Control and Prevention
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Genome-Wide Characterization of Host Transcriptional and Epigenetic Alterations During HIV Infection of T Lymphocytes

Frontiers in Immunology, 2020
Background and methods: Host genomic alterations are closely related to dysfunction of CD4+ T lymphocytes in the HIV–host interplay. However, the roles of aberrant DNA methylation and gene expression in the response to HIV infection are not fully ...
Xi Zeng, Xi Zeng, Joseph Chi-Ching Tsui, Mai Shi, Jie Peng, Cyanne Ye Cao, Lea Ling-Yu Kan, Carol Po-Ying Lau, Yonghao Liang, Lingyi Wang, Li Liu, Zhiwei Chen, Stephen Kwok-Wing Tsui, Stephen Kwok-Wing Tsui, Stephen Kwok-Wing Tsui   +14 more
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IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH

Hepatology, EarlyView., 2022
IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen‐Chieh Chuang, Julie Lin, Wen‐Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris V. Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin   +20 more
wiley   +1 more source

Clinical effectiveness and treatment satisfaction between two triple‐therapy regimens in treating neuropathic pain: A real‐world data

Ibrain, EarlyView., 2023
This study compared the clinical effectiveness and treatment satisfaction of Pregabalin and Gabapentin triple therapy for neuropathic pain in a real‐world setting. The primary outcome measured the reduction in mean Self‐Administered Leeds Assessment of Neuropathic Symptoms and Signs pain score value from baseline to 12 weeks posttreatment.
Nithya Raju, Samyuktha Villavan, Saranya Ravi, Roja Murugesan, Panneerselvam Theivendren, Vennila Jaganathan, Redlin Jani Rajan, Krupanidhi Karunanithi   +7 more
wiley   +1 more source