Results 31 to 40 of about 2,228,702 (296)
FEBS Open Bio, EarlyView.Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia +9 more
wiley +1 more source
Early menopause in acquired immunodeficiency syndrome
Journal of Research in Medical Sciences, 2021 Premature menopause can occur in women living with human HIV. In this study, we analyzed and reviewed published literature using the PubMed, Cochrane, and Embase databases since the year 1990 using a combination of MeSH terms such as “Early,” “Premature,”
Mohamed Hassan Ahmed +7 more
doaj +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Revista da Sociedade Brasileira de Medicina Tropical, 2019 INTRODUCTION: Prevalence of human immunodeficiency virus among adolescents is increasing. This study aimed to analyze this current situation in Rio de Janeiro City.
Stella Regina Taquette +1 more
doaj +1 more source
Advanced Science, EarlyView.FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni +17 more
wiley +1 more source
Clinical Features in Nine Patients with Acquired Immunodeficiency Syndrome [PDF]
, 2000 We encountered nine patients with acquired immunodeficiency syndrome (AIDS). All were men, and ranged in age from 25 to 63 (mean,43.1±13.5years).One patient was a Thailander,one was a Brazilian and the others were Japanese.
山口, 伸二 +13 more
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Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy
Advanced Science, EarlyView.By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng +16 more
wiley +1 more source
Frontiers in Cellular and Infection MicrobiologyBackgroundCytokines in the serum and cerebrospinal fluid (CSF) are critical to the pathogenesis of HIV-associated cryptococcal meningitis (HCM). Previous studies focused on baseline cytokine levels, but changes during antifungal therapy are underexplored.
Rui Su +7 more
doaj +1 more source
A Drug‐Gated, Modular STAb‐T Immunotherapy With External Control
Advanced Science, EarlyView.Engineered STAb‐TON cells act as programmable living factories that continuously secrete inactive antibody modules, which assemble extracellularly into a functional T cell engager only upon small‐molecule administration. This externally controlled platform enables reversible, on‐demand regulation of antitumor immunity, establishing a new paradigm for ...
Susana Luengo‐Arias +23 more
wiley +1 more source
Acquired Immunodeficiency Syndrome (AIDS) [PDF]
, 2007 Acquired Immunodeficiency Syndrome (AIDS) is a fatal syndrome that affects normally healthy individuals who have acquired an immune system deficiency. AIDS is acquired via a viral agent that attacks the immune system of healthy individuals and eventually
David Fleischmann
core +1 more source