Results 61 to 70 of about 286,252 (337)

PBLD Orchestrates the STING‐Mediated Antiviral Immune Response and Autoimmune Diseases

Advanced Science, EarlyView.
During viral infection, PBLD expression is downregulated, thereby subverting host antiviral defenses and promoting viral replication. This study identifies PBLD as a positive regulator of STING‐induced type I interferon activation and delineated the molecular network underlying PBLD‐mediated antiviral immunity and autoimmune pathogenesis, highlighting ...
Peili Hou, Hongchao Zhu, Xiaonan Sun, Ni Zhang, Song Wang, Xuexing Zheng, Xiaoyun Wang, Yueyue Feng, Fuzhen Zhang, Xingyu Li, Rui Li, Xiaomeng Wang, Yuanyuan Han, Jun Wang, Chuanhong Wang, Xiaoyang Yao, Hongmei Wang, Hongbin He   +17 more
wiley   +1 more source

Disability-adjusted life years and mortality rate attributed to unsafe sex and drug use for AIDS in the Middle East and North Africa countries

Archives of Public Health, 2020
Background The Middle East and North Africa, is one of few regions where the number of new human immunodeficiency virus infections is increasing.
Farid Najafi, Fatemeh Khosravi, Mojtaba Ghalandari, Mitra Darbandi   +3 more
doaj   +1 more source

IgG‐Bridging–Seeded Synergistic Aggregation of SARS‐CoV‐2 Spikes Underlies Potent Neutralization by a Low‐Affinity Antibody

Advanced Science, EarlyView.
Low‐affinity antibodies are frequently disregarded in discovery pipelines. This work reports P5‐1C8, a Class 1 SARS‐CoV‐2 antibody with weak trimer binding (KD‐to‐IC50 > 3700‐fold) yet potent neutralization of Omicron JN.1. Structural, biophysical, functional, and coarse‐grained simulations collectively demonstrate that transient inter‐spike IgG ...
Niannian Lv, Peng Chen, Xiaobin Dai, Hu Xu, Ziheng Li, Zelin Shan, Jinqian Li, Fenglin Guo, Yuanfang Chen, Jiayi Li, Yiqian Huang, Guizhi Dong, Yifan Jiang, Liang Chen, Xuanyu Nan, Hanjun Zhao, Kang Zhang, Shilong Fan, Yuanchen Dong, Dongsheng Liu, Xinquan Wang, Deli Huang, Xiaojing Pan, Chunying Chen, Zhihua Liu, Li‐Tang Yan, Qi Zhang, Linqi Zhang, Yuliang Zhao, Yuhe Renee Yang   +29 more
wiley   +1 more source

Aplastic anemia associated to systemic lupus erythematosus in an AIDS patient: a case report

Revista Brasileira de Hematologia e Hemoterapia, 2013
Aplastic anemia is a bone marrow failure syndrome characterized by peripheral cytopenias and hypocellular bone marrow. Although aplastic anemia is idiopathic in most cases, rheumatic diseases such as systemic lupus erythematosus are recognized as causes ...
Leonardo Rodrigues de Oliveira, Thais Camargos Ferreira, Fernando de Freitas Neves, Antonio Carlos de Oliveira Meneses   +3 more
doaj   +1 more source

Immune compromise in HIV-1/HTLV-1 coinfection with paradoxical resolution of CD4 lymphocytosis during antiretroviral therapy: a case report [PDF]

, 2015
Human immunodeficiency virus type-1 (HIV-1) and human T lymphotropic virus type-1 (HTLV-1) infections have complex effects on adaptive immunity, with specific tropism for, but contrasting effects on, CD4 T lymphocytes: depletion with HIV-1, proliferation
Bangham, C, Basnayake, S, Cook, L, Kagdi, H, Pozniak, A, Rockwood, N, Taylor, GP   +6 more
core   +2 more sources

Multimorbidity and animal models

Animal Models and Experimental Medicine, EarlyView.
Multimorbidity, defined as the coexistence of ≥2 chronic conditions, is associated with aging, genetics, and environmental factors. Animal models in multimorbidity research span three tiers: simple organisms for initial screening → rodents for mechanistic analysis → large mammals for clinical prediction.
Xinpei Wang, Yakun Ren, Xingjiu Yang, Mengyuan Li, Junxiu Liu, Xiaoyan Du, Wen Wang, Ran Gao   +7 more
wiley   +1 more source

Systemic infections after acute stroke [PDF]

, 2008
After an acute stroke, systemic infection can complicate the recovery process and lead to a worse clinical outcome, including a higher risk of mortality.
Damian Jenkinson, Englyst, Hamidon, Joseph Kwan, Kammersgaard, Kwan, Mike Vassallo, Nicola Englyst, Niel-Weise, Oconnor, V Hugh Perry, Werner   +11 more
core   +1 more source

Late Pregnancy Antiseizure Medication Exposure and Offspring Neurodevelopmental Risk: A Multi‐Child Cohort Study

Annals of Neurology, EarlyView.
Objective Antiseizure medication (ASM) use during pregnancy has increased over the past decade. However, evidence linking prenatal ASM exposure to neurodevelopmental disorders (NDDs) in offspring remains inconsistent. This study evaluated whether prenatal ASM exposure increases the risk of NDDs in children.
Odile Sheehy, Vanina Tchuente, Sherif Eltonsy, Steven Hawken, Padma Kaul, Mark Walker, Michael Pugliese, Roxana Dragan, Anamaria Savu, Lisiane Leal, Lucie Morin, Isabelle Malhamé, Raluca Pana, Anick Bérard   +13 more
wiley   +1 more source

Factors impacting antiretroviral therapy adherence among human immunodeficiency virus-positive adolescents in Sub-Saharan Africa: a systematic review [PDF]

, 2018
© 2018 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.Objectives: Eighty-two percent of human immunodeficiency virus (HIV)–positive adolescents live in Sub-Saharan Africa (SSA).
Adejumo, Agwu, AIDS.gov, AIDSinfo, AIDSinfo, Ankrah, Bernays, Bezabhe, Bhattacharya, Bikaako-Kajura, Birungi, Braitstein, Bygrave, Centers for Disease Control and Prevention, Cluver, Cohen, Critical Appraisal Skills Programme, Danford, Deeks, Denison, Fair, Famoroti, Ferrara, Fetzer, Finocchario-Kessler, Fongkaew, Gross, Gulick, Haberer, Habib, Harries, Hodgson, Hogwood, Hudelson, J.M. Corkery, Jaspan, Joint United Nations Programme on HIV/AIDS, Katz, Kawuma, Kim, King, Kirk, Klitzman, Krauss, Kunapareddy, Lall, Langat, Lowenthal, Lyimo, Maartens, MacPherson, Manglos, Mavhu, Mbirimtengerenji, Mburu, Mburu, Michaud, Mills, Moon, Murphy, Musumari, Mutumba, Mutwa, N. Ammon, Nabukeera-Barungi, Nachega, Nachega, Nachega, Nachega, National Institutes of Health, Nyogea, Nöstlinger, O'Brien, Park, Preferred Reporting Items for Systematic Reviews and Meta-Analyses, Reda, Reisner, Remien, Roberts, Ross-Degnan, S. Mason, Scanlon, Simoni, Sithole, Siu, Sivapalasingam, Thomas, Tumwine, United Nations International Children's Emergency Fund, United Nations International Children's Emergency Fund, Vaz, Vreeman, Vreeman, Vyas, Wanyama, Wasti, Watt, Wiener, World Health Organization, World Health Organization, World Health Organization, World Health Organization, Zou   +102 more
core   +2 more sources

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source