Results 81 to 90 of about 286,389 (401)
Investigating the role of SARM1 in central nervous system
Sterile‐α and Toll/interleukin 1 receptor (TIR) motif‐containing protein 1 (SARM1) is a pivotal molecule that has garnered extensive attention in neuroscience. As an intracellular molecule, SARM1 possesses various crucial biological functions in the nervous system.
Junjie Wang+4 more
wiley +1 more source
INTRODUCTION: Over 30 years after the acquired immunodeficiency syndrome epidemic, several strategies have been implemented to verify the trend of the infection, the profile of the affected individuals, and the impact of prevention and control measures,
Sybelle de Souza Castro+5 more
doaj +1 more source
Seronegative spondyloarthropathies : a review : part II: genetics and pathogenesis [PDF]
In none of the spondyloarthropathies is the pathogenesis well understood. Much of the investigation into the aetio-pathogenesis of these diseases has focused on the association with HLA-B27 and the known triggering potential of certain infectious agents.
Borg, Andrew A.+2 more
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Gut microbiota and tuberculosis
This review explores the intricate relationship between gut microbiota (GM) and tuberculosis (TB). The figure illustrates the bidirectional effects between GM dynamics and TB progression, as well as the interactions between the GM and antituberculosis drugs.
Yanhua Liu+39 more
wiley +1 more source
OBJETIVO: Analisar a freqüência da tuberculose e das outras principais doenças oportunistas definidoras de síndrome da imunodeficiência adquirida, no momento em que estes casos são notificados, no Município do Rio de Janeiro. MÉTODOS: Análise do banco de
Elizabeth Cristina Coelho Soares+5 more
doaj +1 more source
New insights into applications of base editor in hereditary disorders
Abstract Hereditary disorders are a group of diseases caused by genetic mutations or chromosomal variations. Although the incidence of each genetic disorder is relatively low, patients affected by the disease generally experience a range of severe symptoms, including blindness, disability, and even premature death. In addition, the available treatments
Maoping Cai+8 more
wiley +1 more source
Qualidade de vida de pessoas vivendo com o vírus e síndrome da imunodeficiência humana
Objective to characterize the Brazilian scientific production on the quality of life of people living with human immunodeficiency virus/Acquired Immunodeficiency Syndrome.Methods bibliometric study with 20 dissertations and 18 theses available at the ...
Sergio Vital da Silva+5 more
doaj +1 more source
Harmonizing TREC Thresholds in Newborn Screening for SCID: Insights From Russian Validation Cohort
Refining TREC cutoff values in newborn screening (NBS) for SCID: ROC analysis of a large testing cohort supports increasing the TREC threshold from 100 to 150–200 copies/105 cells, improving assay sensitivity and enabling earlier detection of SCID and other immunodeficiencies.
Andrey Marakhonov+14 more
wiley +1 more source
Effects of Hepatic or Renal Impairment on Pharmacokinetics of Fruquintinib
Abstract Fruquintinib (FRUZAQLATM) is a highly selective tyrosine kinase inhibitor of all three vascular endothelial growth factor receptors (‐1, ‐2, and ‐3). Two Phase 1, open‐label, single‐dose studies investigated the impact of hepatic or renal impairment on the pharmacokinetics and tolerability of fruquintinib.
Martha Gonzalez+8 more
wiley +1 more source
Human Immunodeficiency Virus Related Non-Hodgkin’s Lymphoma
Tesfaye Gessese,1 Fikir Asrie,2 Zewudu Mulatie1 1Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia; 2Department of Hematology and Immunohematology, School of Biomedical and Laboratory ...
Gessese T, Asrie F, Mulatie Z
doaj