Results 111 to 120 of about 45,337 (219)
Exonic Variation and Its Clinical Impact in 7221 Old Order Amish
American Journal of Medical Genetics Part A, Volume 197, Issue 12, December 2025.ABSTRACT The Amish of Lancaster County, PA has been the focus of genetic studies for many years due to its demographic history and unique genetic makeup that includes a historical bottleneck event and subsequent genetic drift, resulting in a marked decrease in genetic diversity and increased frequency of some variants that have substantially shaped the
Braxton D. Mitchell +21 more
wiley +1 more source
The classical “R-on-T” phenomenon
Indian Heart Journal, 2015 The polymorphic ventricular tachycardia (PVT) is uncommon arrhythmia with multiple causes and has been classified according to whether they are associated with long QT interval or normal QT.
Fatih Oksuz +9 more
doaj +1 more source
コウテンセイ QT エンチョウ ショウコウグン ノ ビョウタイ [PDF]
, 2017 The definition of long QT syndrome depends on demonstration of QT prolongation and recurrent syncope due to life-threatening ventricular arrhythmia .
Yamamoto, Hirofumi
core
A Common Genetic Variant Risk Score is Associated with Drug-Induced QT Prolongation and Torsade de Pointes Risk: A Pilot Study. [PDF]
, 2017 Background -Drug-induced QT interval prolongation, a risk factor for life-threatening ventricular arrhythmias, is a potential side effect of many marketed and withdrawn medications.
Behr, ER +11 more
core +2 more sources
Acta Physiologica, Volume 241, Issue 12, December 2025.ABSTRACT Aim Heart failure is a clinical syndrome where the heart's structural or functional impairment leads to inadequate blood flow to meet the body's metabolic demands. Mitochondrial dysfunction is increasingly recognized as a central contributor underlying the contractile impairment observed in the failing heart.
Manuel Vicente +6 more
wiley +1 more source
Revista Portuguesa de Cardiologia, 2018 Sudden cardiac death is a major public health challenge, which can be caused by genetic or acquired structural or electrophysiological abnormalities. These abnormalities include hereditary channelopathies: long QT, short QT and Brugada syndromes.
Diogo Ramalho, João Freitas
doaj +1 more source
Treatment of Adult Patients with Relapsed/Refractory B-Cell Philadelphia-Negative Acute Lymphoblastic Leukemia [PDF]
, 2019 The majority of adult patients affected by B-cell acute lymphoblastic leukemia (B-ALL) will relapse after an initial response, while approximately 20% will display primary resistant disease. Patients suffering from relapsed/refractory B-ALL have a very
Lanza, Francesco +2 more
core +1 more source
Elucidation of the zinc binding site in KCNQ channels
British Journal of Pharmacology, Volume 182, Issue 24, Page 6081-6099, December 2025.Background and Purpose KCNQ1‐5 (Kv7.1–7.5) are members of a family of voltage‐gated potassium channels with prominent function in the nervous and cardiovascular systems and in epithelia. KCNQ channels are activated by intracellular free zinc, but the molecular mechanism of this effect is poorly understood and zinc binding sites within KCNQ channels are
Shuo Zhang +6 more
wiley +1 more source
Liver International, Volume 45, Issue 12, December 2025.ABSTRACT Background and Aim Alagille syndrome (ALGS) is a rare disorder characterised by cholestasis and extrahepatic manifestations. Given the current era of ileal bile acid transporter (IBAT) inhibitor therapies that reduce serum bile acid (SBA) levels, we evaluated whether SBA predicts liver disease outcomes in ALGS.
Carla Fiorella Murillo Perez +97 more
wiley +1 more source
Ventricular Tachycardia in the Absence of Structural Heart Disease [PDF]
, 2005 In up to 10% of patients who present with ventricular tachycardia (VT), obvious structural heart disease is not identified. In such patients, causes of ventricular arrhythmia include right ventricular outflow tract (RVOT) VT, extrasystoles, idiopathic ...
Appleton, Christopher P +4 more
core +1 more source