Results 51 to 60 of about 45,337 (219)

A study of early afterdepolarizations in a model for human ventricular tissue [PDF]

, 2014
Sudden cardiac death is often caused by cardiac arrhythmias. Recently, special attention has been given to a certain arrhythmogenic condition, the long-QT syndrome, which occurs as a result of genetic mutations or drug toxicity. The underlying mechanisms
Kazbanov, Ivan, Nuitermans, Anita, Pandit, Rahul, Panfilov, Alexander, Vandersickel, Nele, Weise, Louis   +5 more
core   +10 more sources

R-from-T as a common mechanism of arrhythmia initiation in long QT syndromes [PDF]

, 2019
Background: Long QT syndromes (LQTS) arise from many genetic and nongenetic causes with certain characteristic ECG features preceding polymorphic ventricular tachyarrhythmias (PVTs).
Liu, Michael B., Panfilov, Alexander, Qu, Zhilin, Vandersickel, Nele   +3 more
core   +2 more sources

CLINICAL SIGNIFICANCE OF DRUGINDUCED INTERVALS QT AND QTC PROLONGATION

Рациональная фармакотерапия в кардиологии, 2015
Interval QT prolongation is a predictor of the life-threatening cardiac arrhythmias — polymorphic ventricular tachycardia (torsade de pointes). Long QT syndrome may be congenital or acquired.
N. V. Furman, S. S. Shmatova
doaj   +3 more sources

Genetics update: monogenetics, polygene disorders and the quest for modifying genes [PDF]

, 2018
The genetic channelopathies are a broad collection of diseases. Many ion channel genes demonstrate wide phenotypic pleiotropy, but nonetheless concerted efforts have been made to characterise genotype-phenotype relationships.
Symonds, Joseph D., Zuberi, Sameer M.
core   +1 more source

Prevalence of Long QT Syndrome in Children with Congenital Sensory-Neural Deafness

Journal of Ardabil University of Medical Sciences, 2021
Background & objectives: Long QT syndrome (LQTS), congenital or acquired disorder, is characterized by a prolonged QT interval associated with syncope attacks and sudden death.
Ahmad Jamei Khosroshahi, Mahmoud Samadi, Shamsi Ghaffari, Akbar Molaei, Fatemeh Chakari   +4 more
doaj  

Long QT interval in resting electrocardiogram – and what next? Sports cardiologist’s pointofview. Part 1. From electrophysiology to diagnostics

Pediatria i Medycyna Rodzinna, 2014
Electrocardiography is the most common and available cardiovascular diagnostic procedure and an important tool in everyday clinical practice of a family physician. Electrocardiogram interpretation is therefore an invaluable clinical skill.
Zbigniew Krenc
doaj   +1 more source

Defying the Odds of Sudden Cardiac Death in Hypertrophic Cardiomyopathy

JACC: Case Reports, 2020
We report an unusual case of a patient with hypertrophic obstructive cardiomyopathy, anomalous aortic origin of a coronary artery, obesity hypoventilation syndrome, and acquired long QT syndrome who was able to defy the odds of sudden cardiac death in ...
Ara H. Rostomian, MD, MPH, MBA, Maxine C. Tang, MD, MS, Kamran Shamsa, MD   +2 more
doaj   +1 more source

Abnormal ECG Findings in Athletes: Clinical Evaluation and Considerations. [PDF]

, 2019
PURPOSE OF REVIEW: Pre-participation cardiovascular evaluation with electrocardiography is normal practice for most sporting bodies. Awareness about sudden cardiac death in athletes and recognizing how screening can help identify vulnerable athletes have
A Biffi, A Biffi, A D’Silva, A D’Silva, A Magalski, A Malhotra, A Malhotra, A Malhotra, A Merghani, A Morshedi-Meibodi, A Pelliccia, A Pelliccia, A Zaidi, A Zaidi, A Zorzi, A Zorzi, A Zorzi, AD Desai, AL Aro, AL Rao, AO Usoro, BJ Maron, BJ Maron, C Antzelevitch, C Calore, C Daubert, C Miles, D Corrado, D Corrado, D Corrado, D Corrado, F D’Ascenzi, F Migliore, F Schnell, FI Marcus, G Finocchiaro, G Malfatto, G Mcclean, GJ Klein, GJ Klein, H Dhutia, H Morita, HUH Virk, J Basu, J Ehtisham, J Marek, J Novak, J Pei, J Steinfurt, JA Drezner, JA Drezner, KG Harmon, KM Park, L Calò, L Verdile, M Brosnan, M Papadakis, M Papadakis, M Sadron Blaye-Felice, MAE Haukilahti, Mark Abela, MG Wilson, MI Cohen, MJ Ackerman, MJ Brosnan, N Chandra, N Panhuyzen-goedkoop, N Sheikh, P Banankhah, PG Postema, PT Matusik, RE Bent, RE Eckart, S Gati, S Kapa, S Masrur, S Peters, S Sharma, S Viskin, Sanjay Sharma, SEE Page, T Senturk, X Li, YH Lee   +83 more
core   +1 more source

Prolonged QT Interval in Cirrhosis: Twisting Time?

Gut and Liver, 2022
Approximately 30% to 70% of patients with cirrhosis have QT interval prolongation. In patients without cirrhosis, QT prolongation is associated with an increased risk of ventricular arrhythmias, such as torsade de pointes (TdP).
William Lee, Bert Vandenberk, Satish R. Raj, Samuel S. Lee   +3 more
doaj   +1 more source

Gain of function mutants: Ion channels and G protein-coupled receptors [PDF]

, 2000
Many ion channels and receptors display striking phenotypes for gain-of-function mutations but milder phenotypes for null mutations. Gain of molecular function can have several mechanistic bases: selectivity changes, gating changes including constitutive
Karschin, Andreas, Lester, Henry A.
core   +1 more source