Sex Hormones and Repolarization Dynamics During the Menstrual Cycle in Women Treated With QT-Prolonging Drugs. [PDF]
Ann Noninvasive ElectrocardiolSex hormones significantly influence ventricular repolarization in women treated with QT‐prolonging drugs, with estrogen prolonging and progesterone/testosterone shortening QT measures. These findings highlight a hormonal mechanism for sex‐specific arrhythmia risk and support closer monitoring of reproductive‐age women receiving QT‐prolonging therapies.
San A +11 more
europepmc +2 more sources
CaMKII-dependent regulation of cardiac Na(+) homeostasis. [PDF]
, 2014 Na(+) homeostasis is a key regulator of cardiac excitation and contraction. The cardiac voltage-gated Na(+) channel, NaV1.5, critically controls cell excitability, and altered channel gating has been implicated in both inherited and acquired arrhythmias.
Grandi, Eleonora, Herren, Anthony W
core +2 more sources
Comparative Characteristics of Beta-Blockers in Patients with Congenital Long QT Syndrome
Рациональная фармакотерапия в кардиологии, 2021 Congenital long QT syndrome is a pathology that requires special attention and knowledge about the safety and effectiveness of various medications.
A. Yu. Proshlyakov +2 more
doaj +1 more source
Sudden cardiac death in young athletes: Literature review of molecular basis [PDF]
, 2020 Intense athletic training and competition can rarely result in sudden cardiac death (SCD). Despite the introduction of pre-participation cardiovascular screening, especially among young competitive athletes, sport-related SCD remains a debated issue ...
Barbara Lombardo +5 more
core +1 more source
Restricting excessive cardiac action potential and QT prolongation: a vital role for IKs in human ventricular muscle [PDF]
, 2005 Background - Although pharmacological block of the slow, delayed rectifier potassium current (I-Ks) by chromanol 293B, L-735,821, or HMR-1556 produces little effect on action potential duration (APD) in isolated rabbit and dog ventricular myocytes, the ...
Biliczki, Péter +10 more
core +1 more source
A common cardiac sodium channel variant associated with sudden infant death in African Americans, SCN5A S1103Y. [PDF]
, 2006 Thousands die each year from sudden infant death syndrome (SIDS). Neither the cause nor basis for varied prevalence in different populations is understood.
Bowers, Peter N +8 more
core +2 more sources
The Genetics of Acquired Long QT Syndrome
Japanese Journal of Electrocardiology, 2019 Hideki Itoh
openalex +3 more sources
A study of early afterdepolarizations in a model for human ventricular tissue [PDF]
, 2014 Sudden cardiac death is often caused by cardiac arrhythmias. Recently, special attention has been given to a certain arrhythmogenic condition, the long-QT syndrome, which occurs as a result of genetic mutations or drug toxicity. The underlying mechanisms
Kazbanov, Ivan +5 more
core +10 more sources
Torsades de pointes in the PACU after outpatient endoscopy: a case report
BMC Anesthesiology, 2021 Background This case demonstrates the severe electrolyte derangements that may present after a common therapy such as a bowel preparation for an outpatient procedure and the rare yet potential detrimental outcomes of those abnormalities.
Andrew Schaar +2 more
doaj +1 more source
Genetics update: monogenetics, polygene disorders and the quest for modifying genes [PDF]
, 2018 The genetic channelopathies are a broad collection of diseases. Many ion channel genes demonstrate wide phenotypic pleiotropy, but nonetheless concerted efforts have been made to characterise genotype-phenotype relationships.
Symonds, Joseph D., Zuberi, Sameer M.
core +1 more source