Results 81 to 90 of about 46,008 (253)

[The risk of acquired long QT syndrome during a coronavirus epidemic. Focus on hydroxychloroquine].

open access: yesOrvosi Hetilap, 2020
Hydroxychloroquine is an immunomodulatory agent used primarily in malaria, lupus erythematosus, and rheumatoid arthritis. The authors summarize the potential proarrhythmic effect of this formulation and the key signs of drug-induced long QT syndrome. The
J. Tomcsányi, Kristóf Tomcsányi
semanticscholar   +1 more source

Artificial intelligence in preclinical epilepsy research: Current state, potential, and challenges

open access: yesEpilepsia Open, EarlyView.
Abstract Preclinical translational epilepsy research uses animal models to better understand the mechanisms underlying epilepsy and its comorbidities, as well as to analyze and develop potential treatments that may mitigate this neurological disorder and its associated conditions. Artificial intelligence (AI) has emerged as a transformative tool across
Jesús Servando Medel‐Matus   +7 more
wiley   +1 more source

Systems Pharmacology [PDF]

open access: yes, 2008
The slides are from a presentation given by Professor Ravi Iyengar from Mount Sinai School of Medicine at the Drug Forum Meeting #9 that took place in Washington, DC on February 20-21, 2008.
Ravi Iyengar
core   +2 more sources

QT Prolongation and Acquired Long QT Syndrome in Climbers on Mount Everest

open access: hybridJACC: Clinical Electrophysiology
Thomas Pilgrim   +9 more
openalex   +3 more sources

Unmasking Long QT Syndrome in the Emergency Department: A Case Report

open access: yesClinical Practice and Cases in Emergency Medicine, 2021
Introduction: Long QT syndrome (LQTS) is an uncommon disorder that can lead to potentially life-threatening dysrhythmias. LQTS can be genetic, acquired, or both.
Eric Leslie   +2 more
doaj   +1 more source

Andersen-Tawil Syndrome [PDF]

open access: yes, 2006
Andersen-Tawil syndrome (ATS) is a rare condition consisting of ventricular arrhythmias, periodic paralysis, and dysmorphic features. In 2001, mutations in KCNJ2, which encodes the α subunit of the potassium channel Kir2.1, were identified in patients ...
Fish, Frank A   +2 more
core   +2 more sources

Arrhythmic risk in elderly patients candidates to transcatheter aortic valve replacement. predicative role of repolarization temporal dispersion [PDF]

open access: yes, 2019
Degenerative aortic valve stenosis (AS) is associated to ventricular arrhythmias and sudden cardiac death, as well as mental stress in specific patients. In such a context, substrate, autonomic imbalance as well as repolarization dispersion abnormalities ...
Crapanzano, Davide   +11 more
core   +1 more source

Accelerating virtual patient generation with a Bayesian optimization and machine learning surrogate model

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 486-494, March 2025.
Abstract The pharmaceutical industry has increasingly adopted model‐informed drug discovery and development (MID3) to enhance productivity in drug discovery and development. Quantitative systems pharmacology (QSP), which integrates drug action mechanisms and disease complexities to predict clinical endpoints and biomarkers is central to MID3.
Hiroaki Iwata, Ryuta Saito
wiley   +1 more source

Moderately Prolonged QTc in Computer-Assessed ECG, Random Variation or Significant Risk Factor? A Literature Review

open access: yesCardiogenetics, 2022
Most ECGs in European hospitals are recorded with equipment giving computer measured intervals and interpretation of the recording. In addition to measurements of interval and QRS axis, this interpretation frequently provides the Bazett’s-corrected QTc ...
Jan Hysing   +4 more
doaj   +1 more source

International Guideline on the Diagnosis and Management of Pediatric Patients With Hereditary Angioedema

open access: yesAllergy, EarlyView.
ABSTRACT Hereditary angioedema (HAE) with C1 inhibitor deficiency is a rare disease characterized by unpredictable episodes of tissue swelling (angioedema), which, in most cases, occur first under the age of 18 years, and entail a significant burden of disease not only for the patients but also for their families.
Henriette Farkas   +128 more
wiley   +1 more source

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