Results 61 to 70 of about 6,257,191 (161)

Von Willebrand Factor and ADAMTS13 in Relation to Atherosclerosis in the General Population: The Rotterdam Study

European Journal of Haematology, EarlyView.
ABSTRACT Background Higher von Willebrand factor (VWF) levels and lower ADAMTS13 activity are linked to increased risk of atherosclerotic cardiovascular disease, but their association with atherosclerosis burden, a potential underlying mechanism, remains unclear.
Mitra Nekouei Shahraki, Frank W. G. Leebeek, Moniek P. M. de Maat, Maryam Kavousi, Daniel Bos   +4 more
wiley   +1 more source

Performing Large‐Scale Genetic Analysis in the Bleeding Disorders Community

Haemophilia, EarlyView.
ABSTRACT Inherited bleeding disorders encompass a diverse group of conditions caused by genetic defects affecting coagulation factors, fibrinogen, von Willebrand factor, or platelet function. Despite major advances in quantitative and functional laboratory assays, a substantial diagnostic gap remains, particularly in patients with mild or atypical ...
Anna R. Blankstein, Sterre P. E. Willems, Saskia E. M. Schols, Rosanna Asselta, Gillian Lowe, Neil V. Morgan, Paula D. James   +6 more
wiley   +1 more source

Study on the mechanism of bleeding in acquired von Willebrand syndrome [PDF]

, 1997
P(論文)The mechanism of bleeding in acquired von Willebrand syndrome (a-vWS), which is associated with several kinds of disorders, is not established. This report investigated the pathogenesis of a-vWS associated with essential thrombocythemia (ET) and ...
河野, 通史, 小池, 隆夫, 安河内, 太郎, 36936, 36937, 36938, 36939, 25285, 垂水, 隆志, 家子, 正裕, 36940, 36941, 沢田, 賢一, 能登谷, 京   +13 more
core  

Acquired von Willebrand Syndrome in an Infant With Coarctation of the Aorta and Williams Syndrome

, 2017
An infant with coarctation of the aorta and Williams syndrome was noted to have petechiae in cardiology clinic prior to planned surgical intervention.
Clinton D. Cochran, Sonal T. Owens, Rohit S. Madani, Steven Pipe, Daniel Peltier   +4 more
core   +1 more source

Temperature-Dependence of Weibel-Palade Body Exocytosis and Cell Surface Dispersal of von Willebrand Factor and Its Propolypeptide [PDF]

, 2011
Background: Weibel-Palade bodies (WPB) are endothelial cell (EC) specific secretory organelles containing Von Willebrand factor (VWF). The temperature-dependence of Ca2+-driven WPB exocytosis is not known, although indirect evidence suggests that WPB ...
Hewlett, L, Matthew J. Hannah, Carter, T, David Ogden, Hannah, MJ, Matthew J Hannah, Mashanov, G, Gregory Mashanov, Zupančič, G, Knipe, L, Tom Carter, Laura Knipe, Gregor Zupančič, Ogden, D, Lindsay Hewlett, Zupančič Gregor, Hannah, Matthew J., Ogden, David, Hewlett, Lindsay, Carter Tom, Hannah Matthew J., Knipe, Laura, Mashanov, Gregory, Ogden David, Zupančič, Gregor, Hewlett Lindsay, Carter, Tom D., Mashanov Gregory, Knipe Laura   +28 more
core   +1 more source

Rare Bleeding Disorders and Bleeding Disorder of Unknown Cause: Current Understanding and Recent Developments

Haemophilia, EarlyView.
ABSTRACT Rare bleeding disorders (RBDs) represent a diverse group of inherited conditions involving coagulation factors or platelets. These conditions, such as Glanzmann thrombasthenia (GT) or severe coagulation factor deficiencies, are uncommon. In contrast, bleeding disorder of unknown cause (BDUC) is a diagnosis of exclusion without an identifiable ...
Alessandro Casini, Robert Klamroth, Bauke Haisma, Dino Mehic, Saskia E. M. Schols   +4 more
wiley   +1 more source

Acquired von Willebrand Syndrome in Patients With Ventricular Assist Device

Frontiers in Medicine, 2019
During the last decade the use of ventricular assist devices (VADs) for patients with severe heart failure has increased tremendously. However, flow disturbances, mainly high shear induced by the device is associated with bleeding complications.
Antoine Rauch, Antoine Rauch, Sophie Susen, Sophie Susen, Barbara Zieger   +4 more
doaj   +1 more source

Smartphone‐Based Teledentistry to Support Clinical Triage and Risk‐Informed Dental Care in Patients With Inherited Bleeding and Haemoglobin Disorders: A Cross‐Sectional Diagnostic Agreement Study

Haemophilia, EarlyView.
ABSTRACT Introduction Patients with inherited bleeding and haemoglobin disorders face barriers to accessing timely dental care, increasing the risk of untreated oral disease and complications related to invasive procedures. Aim To evaluate the agreement between smartphone‐based asynchronous teledentistry and face‐to‐face examination for oral conditions,
Victor Cordeiro da Silva, Carolina Mendes Frusca do Monte, Leandro Tavares da Silva, Gabriela Silva Almeida, Claudia Santos Lorenzato, José Vitor Nogara Borges de Menezes, Fabian Calixto Fraiz, Cassius Carvalho Torres‐Pereira   +7 more
wiley   +1 more source

Acquired von Willebrand syndrome in respiratory extracorporeal life support: A systematic review of the literature

, 2017
Background and objective: Venovenous extracorporeal membrane oxygenation (VV ECMO) and extracorporeal CO2 removal (ECCO2R) are increasingly used in the management of severe respiratory failure.
von Bahr, V, Obonyo, NG, Millar, JE, Malfertheiner, MV, Suen, JY, Fraser, JF, Pimenta, LP, Pellegrino, V   +7 more
core   +1 more source

How I Investigate Bleeding Disorders of Unknown Cause: Current Diagnostic Pathways and Gaps in Laboratory Investigation

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Bleeding disorder of unknown cause (BDUC) constitutes the largest group of patients presenting with a mild‐to‐moderate bleeding tendency in tertiary care settings. Their clinical bleeding phenotype is characterized by mucocutaneous bleeding, as well as bleeding following surgical challenges or childbirth, and is associated with impaired health‐
Dino Mehic, Faris Karaselimovic, Tim Dreier, Johanna Gebhart   +3 more
wiley   +1 more source