Results 11 to 20 of about 325,115 (264)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

What is the source of L1 attrition? The effect of recent L1 re-exposure on Spanish speakers under L1 attrition [PDF]

open access: yes, 2015
The recent hypothesis that L1 attrition affects the ability to process interface structures but not knowledge representations (Sorace, 2011) is tested by investigating the effects of recent L1 re-exposure on antecedent preferences for Spanish pronominal ...
Sturt, Patrick   +2 more
core   +1 more source

The Syntactic Domain of Content

open access: yes, 2013
Borer, H. in press. 'The Syntactic Domain of Content.' In Becker, Misha, John Grinstead and Jason Rothman (eds.), Generative Linguistics and Acquisition: Studies in honor of Nina M. Hyams. 2013. vi, 355 pp. + index (pp. 205–248). http://benjamins.com/#
Hagit Borer, BORER, H
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Morphology, derivational syntax and second language acquisition of resultatives [PDF]

open access: yes, 2005
This thesis explores questions of functional morphology in morphosyntactic theory and in second language acquisition. The work develops Emonds' (2000) notion of a Syntacticon as the store of grammatical lexical items in the Lexicon and it explores the ...
Whong-Barr, Melinda   +1 more
core  

Generative SLA in the age of minimalism: features, interfaces, and beyond : selected proceedings of the 15th Generative approaches to second language acquisition conference Language acquisition & language disorders ;, v.67./ edited by Tania Leal, Elena Shimanskaya, Casilde A. Isabelli, University of Nevada, Reno.

open access: yes, 2022
Proceedings of the 15th Generative approaches to second language acquisition conference which took place at the University of Nevada, Reno on March 22-24, 2019.Includes bibliographical references and index."This volume brings together empirical studies ...
Shimanskaya Elena   +2 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Lexical Link Analysis Application: Improving Web Service to Acquisition Visibility Portal Phase II [PDF]

open access: yes, 2014
Proceedings of the Eleventh Annual Acquisition Research Symposium, Thursday Sessions Volume II.We define awareness as the cognitive interface between decision-makers and a complex system, expressed in a range of terms or features, or specific vocabulary ...
Gallup, Shelley   +2 more
core  

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