Results 31 to 40 of about 325,115 (264)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Optionality in L2 grammars: the acquisition of SV/VS contrast in Spanish [PDF]
, 2008 This study examines the L2 acquisition of word order variation in Spanish by three groups of L1 English learners in an instructed setting. The three groups represent learners at three different L2 proficiencies: beginners, intermediate and advanced.
Domínguez, Laura, Arche, María J.
core
Acquisition of OWL DL Axioms from Lexical Resources
, 2007 Völker J, Hitzler P, Cimiano P. Acquisition of OWL DL Axioms from Lexical Resources. In: Franconi E, Kifer M, May W, eds. The Semantic Web: Research and Applications, 4th European Semantic Web Conference, ESWC 2007, Innsbruck, Austria, June 3-7, 2007 ...
Völker, Johanna +8 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
CIRCLING INTERFACE: AN ALTERNATIVE INTERACTION METHOD FOR ON-SCREEN OBJECT MANIPULATION [PDF]
, 2013 An alternative interaction method, called the circling interface, was developed and evaluated for individuals with disabilities who find it difficult or impossible to consistently and efficiently perform pointing operations involving the left and right ...
Ka, Hyun
core
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
Acquisition of tense and aspect by Persian learners of English as a second language [PDF]
, 1998 This dissertation is a cross-sectional study of the acquisition of tense and aspect by 45 Persian speakers as the experimental group and 15 native English speaking children as the control group.
Jabbari, Ali Akbar
core
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Improved Software Testing for Open Architecture [PDF]
, 2010 Proceedings Paper (for Acquisition Research Program)Applying traditional manual US Navy testing practices to OA systems will limit many benefits of OA, such as system scalability, rapid configuration changes, and effective component reuse.
Berzins, Valdis, Dailey, Paul
core