Results 51 to 60 of about 314,382 (265)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design of physiological data acquisition and processing system for underground personnel

Gong-kuang zidonghua, 2017
A design scheme of physiological data acquisition and processing system for underground personnel was proposed. Hardware design of data acquisition terminal, data acquisition and processing method and ZigBee data transmission design of the system were ...
GUO Tianwen, HUI Qiang, PAN Yuanhong, QIAO Ziyu, JI Xiaoxiang   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Design of professional audio interface available for electroacoustic testing system

Dianzi Jishu Yingyong, 2019
Aiming at low cost and high performance for audio interface requirements used in the electroacoustic testing system, a special audio interface is designed, which is composed of the slave computer embedded system and the host computer software.
Zhou Jinglei, Li Tengfei, Feng Yuan
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Research of Data Acquisition System Based on LabVIEW

Gong-kuang zidonghua, 2010
In view of problems that data acquisition card must be used to collect experimental data in use of virtual instrument and price of private data acquisition card is very high, the paper put forward a design scheme of data acquisition system based on ...
LI Tao, LEI Wan-zhong
doaj  

Nexus: A Modular Open-Source Multichannel Data Logger—Architecture and Proof of Concept

Automation
This paper presents Nexus, a proof-of-concept low-cost, modular, and reprogrammable multichannel data logger aimed at validating the architectural feasibility of an open and scalable acquisition platform for scientific instrumentation.
Marcio Luis Munhoz Amorim, Oswaldo Hideo Ando Junior, Mario Gazziro, João Paulo Pereira do Carmo   +3 more
doaj   +1 more source