Results 71 to 80 of about 314,382 (265)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Os *caracoles são azules? Dados espontâneos e experimentais sobre a aquisição dos plurais das palavras com lateral final

Linguística, 2017
The paper describes longitudinal spontaneous and experimental cross-sectional production data from Portuguese children on the acquisition of irregular plural forms of words with final lateral.
Maria João Freitas, Catarina Afonso
doaj  

Development of graphical user interface for design of experiments via Gaussian process regression and its case study

Science and Technology of Advanced Materials: Methods
Bayesian optimization, coupled with Gaussian process regression and acquisition functions, has proven to be a powerful tool in the field of experimental design.
Yoshiki Hasukawa, Mikael Kuwahara, Lauren Takahashi, Keisuke Takahashi   +3 more
doaj   +1 more source

Emergent Frameworks for Decision Support Systems [PDF]

Informatică economică, 2011
Knowledge is generated and accessed from heterogeneous spaces. The recent advances in in-formation technologies provide enhanced tools for improving the efficiency of knowledge-based decision support systems.
Ioana Andreea STANESCU, Florin Gheorghe FILIP   +1 more
doaj  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Interfaces with syntax in language acquisition

, 2016
published
Kupisch, Tanja, Rothman, Jason
openaire   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Mergers And Acquisitions: An Interface To Economic Development

International Journal of Engineering and Advanced Technology, 2019
Economic development is a wide aspect which gradually is one of the sole motives of any country. There are numerous ways by which they try to achieve this goal and become a powerful country among all other nations. Financial power is one such power which keeps any nation on its toes to make any powerful decisions, at any time of the day.
Angi Sinha, Astha Srivastava, Anwesha Pathak   +2 more
openaire   +1 more source