Results 161 to 170 of about 508,488 (299)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Enhanced Identifications and Quantification Through Retention Time Down-Sampling in Fast-Cycling Diagonal-PASEF Methods. [PDF]

Mol Cell Proteomics
Below CR, Bernhardt OM, Kaspar-Schönefeld S, Willems S, Coronado E, Karemaker ID, Streckenbach B, Pepelnjak M, Räss L, Schär S, Trede D, Krieger JR, Gandhi T, Bruderer R, Reiter L.   +14 more
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Bicomponent Mapping of Cortical Bone Using a New Interleaved UTE Imaging Sequence. [PDF]

Magn Reson Med
Shin SH, Athertya JS, Suprana A, Lo J, Wang J, Moazamian D, Chapelin F, Ma Y.   +7 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Mergers and Acquisitions [PDF]

Alan J. Auerbach, David Reishus
core   +3 more sources

LesionSCynth: A simple parametric lesion synthesis method to improve spinal cord lesion segmentation in low-data scenarios. [PDF]

Imaging Neurosci (Camb)
Walsh R, Kaur P, Karimi D, Kerbrat A, Warfield SK, Galassi F, Combès B.   +6 more
europepmc   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Trends in Private Equity Acquisitions of Assisted Living Facilities.

JAMA Netw Open
Bunker JN, Singh Y, Gadkari G, Bowblis J, Smith L, Carder P, Huang S, Rahman M, Thomas KS.   +8 more
europepmc   +1 more source

Feasibility of opportunistic dental diagnostics in routine photon-counting CT examinations of the cervical spine. [PDF]

BMC Oral Health
Sawall S, Maier J, Sen S, Gehrig H, Kim TS, Ziener CH, Schlemmer HP, Schoenberg SO, Froelich MF, Kachelrieß M, Ruetters M.   +10 more
europepmc   +1 more source