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2014
Acromegaly is due to excessive production of growth hormone (GH), generally by a pituitary GH-secreting adenoma. Its prevalence is estimated at 40-130 cases per million inhabitants. Acromegaly is characterized by slowly progressive acquired somatic disfigurement (mainly involving the face and extremities) and systemic manifestations. The rheumatologic,
Philippe, Chanson +2 more
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Acromegaly is due to excessive production of growth hormone (GH), generally by a pituitary GH-secreting adenoma. Its prevalence is estimated at 40-130 cases per million inhabitants. Acromegaly is characterized by slowly progressive acquired somatic disfigurement (mainly involving the face and extremities) and systemic manifestations. The rheumatologic,
Philippe, Chanson +2 more
openaire +2 more sources
Minerva Endocrinology, 2018
Growth hormone (GH) and insulin-like growth factor-I (IGF-I) have pleiotropic effects on the skeleton throughout the lifespan by influencing bone formation and resorption. Despite these positive effects on skeletal metabolism, in presence of GH and IGF-I excess, bone turnover increases excessively leading to deterioration of bone microarchitecture and ...
Filippo, Maffezzoni, Anna M, Formenti
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Growth hormone (GH) and insulin-like growth factor-I (IGF-I) have pleiotropic effects on the skeleton throughout the lifespan by influencing bone formation and resorption. Despite these positive effects on skeletal metabolism, in presence of GH and IGF-I excess, bone turnover increases excessively leading to deterioration of bone microarchitecture and ...
Filippo, Maffezzoni, Anna M, Formenti
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Annals of Internal Medicine, 1981
Excerpt Acromegaly is a chronic disease not to be neglected. In addition to its metabolic abnormalities that are the consequence of excessive growth hormone secretion, neurologic sequelae can be ca...
O H, Pearson, B, Arafah, J, Brodkey
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Excerpt Acromegaly is a chronic disease not to be neglected. In addition to its metabolic abnormalities that are the consequence of excessive growth hormone secretion, neurologic sequelae can be ca...
O H, Pearson, B, Arafah, J, Brodkey
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The Journal of Clinical Endocrinology & Metabolism, 1954
THE occurrence of two normal pregnancies in an acromegalic female afforded an opportunity for a detailed study of this rather unusual relationship. A review of the world literature revealed 33 reported cases of pregnancy occurring in patients with acromegaly.
W A, ABELOVE, J J, RUPP, K E, PASCHKIS
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THE occurrence of two normal pregnancies in an acromegalic female afforded an opportunity for a detailed study of this rather unusual relationship. A review of the world literature revealed 33 reported cases of pregnancy occurring in patients with acromegaly.
W A, ABELOVE, J J, RUPP, K E, PASCHKIS
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The American Journal of the Medical Sciences, 1984
Ten patients with acromegaly, six with active acromegaly and four with inactive acromegaly were studied with regard to the possible relationship between aldosterone metabolism and hypertension. It was noted that tetrahydroaldosterone-3-glucuronide levels were highest in those cases which exhibited the highest prolactin levels.
P, Marks +3 more
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Ten patients with acromegaly, six with active acromegaly and four with inactive acromegaly were studied with regard to the possible relationship between aldosterone metabolism and hypertension. It was noted that tetrahydroaldosterone-3-glucuronide levels were highest in those cases which exhibited the highest prolactin levels.
P, Marks +3 more
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Neuroendocrinology, 2015
Pierre Marie coined the term ‘acromegaly' in 1886 and linked it to a distinct clinical disease with a characteristic clinical picture. However, Pierre Marie was not the first physician to give a full record of the clinical picture of acromegaly; others had preceded him, like the Dutch physician Johannes Wier.
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Pierre Marie coined the term ‘acromegaly' in 1886 and linked it to a distinct clinical disease with a characteristic clinical picture. However, Pierre Marie was not the first physician to give a full record of the clinical picture of acromegaly; others had preceded him, like the Dutch physician Johannes Wier.
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Pathophysiology of Acromegaly*
Endocrine Reviews, 1983This review discusses the pathophysiology of acromegaly. Acromegaly has been classified in this paper into distinct entities based on etiology, ultrastructural features of the pituitary, and cytogenesis. This classification has been proposed based on clinical signs, immunoperoxidase techniques, transmission electromicroscopy and immunoelectron ...
S, Melmed +4 more
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Clinical and Experimental Dermatology, 1991
A 56-year-old man with long-standing chronic plaque psoriasis was noted to be acromegalic. Investigations confirmed the presence of a large pituitary adenoma and following treatment of this by hypophysectomy his psoriasis cleared dramatically within 3 weeks.
D J, Todd, D J, Eedy, J C, McMillan
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A 56-year-old man with long-standing chronic plaque psoriasis was noted to be acromegalic. Investigations confirmed the presence of a large pituitary adenoma and following treatment of this by hypophysectomy his psoriasis cleared dramatically within 3 weeks.
D J, Todd, D J, Eedy, J C, McMillan
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Endocrinology and Metabolism Clinics of North America, 1991
Acromegaly may result from ectopic production of the hypothalamic peptide, growth hormone releasing hormone (GHRH), or growth hormone (GH) itself. Hypothalamic, carcinoid, and pancreatic tumors account for most of these cases. The pathogenesis, etiology, and diagnosis of acromegaly caused by these nonpituitary tumors is discussed, and an approach to ...
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Acromegaly may result from ectopic production of the hypothalamic peptide, growth hormone releasing hormone (GHRH), or growth hormone (GH) itself. Hypothalamic, carcinoid, and pancreatic tumors account for most of these cases. The pathogenesis, etiology, and diagnosis of acromegaly caused by these nonpituitary tumors is discussed, and an approach to ...
openaire +2 more sources