Results 131 to 140 of about 5,566 (287)

CALB2 is a Mechanoresistance Gene in Metastatic Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer cell lines of differing origins were cultured over many passages while being subjected to semi‐lethal levels of fluid shear stress, representing the harsh mechanical environment these cells are subjected to in the circulation during the process of distant metastasis.
Abigail R. Fabiano, Allen C. Luo, Paul Taufalele, Jenna A. Dombroski, Ehsan Aalaei, Schyler J. Rowland, Melissa S. Cantú, Alexandria T. Carter, Samantha V. Knoblauch, Cynthia A. Reinhart‐King, Michael R. King   +10 more
wiley   +1 more source

Thermal Stability and Utility of Dienes as Protecting Groups for Acrylamides

Acrylamides are privileged electrophiles used in targeted covalent therapies, often installed at the end of a synthetic sequence due to their reactive nature.
Alexander S. Burns (5445590), Annie R. Hooper (12419382)   +1 more
core   +1 more source

Synthesis of Quinolinones with Palladium-Catalyzed Oxidative Annulation between Acrylamides and Arynes

, 2016
An unprecedented palladium-catalyzed oxidative annulation of acrylamides with benzyne precursors has been successfully developed. By using this mild “N–H activation/Heck reaction” method, a wide variety of quinolinones were conveniently prepared in one ...
Xiangyun Zhao (1642981), Chen-Ho Tung (654283), Zhenghu Xu (129883), Weiguo Wang (538511), Xiaoyu Qin (1642984), Chen Ma (714759), Xianglong Peng (1642987)   +6 more
core   +1 more source

Bound Water as a Reinforcing Element for Ultra‐Strong Polyacrylamide

Advanced Science, EarlyView.
Rather than acting as a conventional plasticizer, bound water serves as a reinforcing element in polyacrylamide by constructing strong PAM–water–PAM hydrogen‐bond networks. This water‐mediated architecture delivers ultra‐high mechanical strength and exceptional flame resistance, redefining the role of water in polymer reinforcement.
Sirawit Pruksawan, Nannan Li, Zehuang Lin, Jianwei Zheng, Terence Jun En Loh, Yi Ting Chong, Junhua Kong, Xunan Hou, Xian Jun Loh, Chaobin He, FuKe Wang   +10 more
wiley   +1 more source

Leveraging molecular descriptors and explainable machine learning for monomer conversion prediction in photoinduced electron transfer-reversible addition-fragmentation chain transfer polymerization

Scientific Reports
This study presents a molecular descriptor-based machine learning (ML) architecture for predicting monomer conversion in photoinduced electron transfer-reversible addition-fragmentation chain transfer (PET-RAFT) polymerization systems. Unlike traditional
Berna Alemdag, Azra Kocaarslan, Gözde Kabay   +2 more
doaj   +1 more source

Tunable Reversible Photochromic Ultralong Organic Phosphorescence via a Universal Phenylpyridine Noncovalent Assembly Strategy

Advanced Science, EarlyView.
A concise supramolecular assembly strategy using α‐cyclodextrin and phenylpyridine derivatives affords dual‐functional materials with switchable multicolor photochromism and tunable ultralong organic phosphorescence, offering new platforms for various photonic applications. ABSTRACT Supramolecular photochromic materials capable of reversible alteration
Xue Bai, Renliang Wang, Hong‐Jin Xue, Zhuofan Jiang, Shuo Yang, Chiming Li, Yanqing Ge, Caihong Liu, Xian‐Yin Dai   +8 more
wiley   +1 more source

Probiotic‐Derived Vesicles Rectally Delivered via Thermo‐Gelling Copolymer Promote Mucosal Healing and Reduce Inflammation in Ulcerative Colitis

Advanced Science, EarlyView.
A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal, Ubaid Tariq, Shreya Mehrotra, Saravanan Matheshwaran, Jan Marsal, Ashok Kumar   +5 more
wiley   +1 more source

Programmable Encapsulation Enables On‐Demand Proliferation of Therapeutic Bacteria for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
A programmable encapsulation technology is developed to reduce bacterial immunogenicity and proliferation after systemic administration. The cross‐linked polymer networks around individual bacteria enable immunogenic shielding and permit selective proliferation in tumors, allowing the bacteria to convert tumor‐accumulated ammonia into L‐arginine and ...
Jianhui Yang, Ao Peng, Shuaiqiang Li, Yaning Huang, Jian Yan, Leyuan Wang, Zhihui Zhu, Fei‐Long Liu, Erbao Bian, Yang Liu, Dasheng Tian, Fenghe Li, Qi Liu   +12 more
wiley   +1 more source

The Regio- and Stereoselective One-Pot Catalytic Preparation of β-Selenyl Acrylamides

, 2016
Pd(PPh3)4 is found to catalytically assemble sulfenamides, terminal aliphatic alkynes, carbon monoxide, and diphenyl diselenides regio- and stereoselectively in a single-pot reaction to produce good yields of β-selenyl ...
Tara Y. Meyer (1532398), Daniel J. Knapton (2693998)   +1 more
core   +1 more source

Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation

Advanced Science, EarlyView.
Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon, Maria Tsiokou, Patricia Marqués, Enriqueta Rodríguez‐Diaz, Hazel Ang, Federico Pietrocola, Christian G. Riedel   +6 more
wiley   +1 more source