Results 51 to 60 of about 4,287,423 (312)

Improved migration of tumor ascites lymphocytes to ovarian cancer microenvironment by CXCR2 transduction

OncoImmunology, 2018
Chemokines are essential mediators of cellular trafficking, interactions and tumor development. Though adoptive cell therapy (ACT) has been a tremendous success in the treatment of metastatic melanoma (MM), a major obstacle for successful ACT, is limited
Manja Idorn, Maria Olsen, Hólmfrídur Rósa Halldórsdóttir, Signe Koggersbøl Skadborg, Magnus Pedersen, Claus Høgdall, Estrid Høgdall, Özcan Met, Per thor Straten   +8 more
doaj   +1 more source

Free treatment, rapid malaria diagnostic tests and malaria village workers can hasten progress toward achieving the malaria related millennium development goals: The Médecins Sans Frontières experience from Chad, Sierra-Leone and Mali

Journal of Public Health in Africa, 2011
Halving the burden of malaria by 2015 and ensuring that 80% of people with malaria receive treatment is among the health related targets of the Millennium Development Goals (MDGs). Despite political momentum toward achieving this target, progress is slow
Katie Tayler-Smith, Alice Kociejowski, Nadine de Lamotte, Seco Gerard, Frederique Ponsar, Mit Philips, Rony Zachariah   +6 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma.

Cancer Cell, 2014
Sonic hedgehog (Shh), a soluble ligand overexpressed by neoplastic cells in pancreatic ductal adenocarcinoma (PDAC), drives formation of a fibroblast-rich desmoplastic stroma.
A. Rhim, A. Rhim, P. Oberstein, Dafydd H. Thomas, Emily T Mirek, Carmine F. Palermo, Stephen A. Sastra, Erin N Dekleva, T. Saunders, Claudia P. Becerra, I. Tattersall, C. B. Westphalen, J. Kitajewski, Maite G. Fernández-Barrena, M. Fernandez-Zapico, C. Iacobuzio-Donahue, K. Olive, B. Stanger   +17 more
semanticscholar   +1 more source

Economic evaluation of return-to-work interventions for mental disorder-related sickness absence: two years follow-up of a randomized clinical trial

Scandinavian Journal of Work, Environment & Health, 2022
OBJECTIVE: The objective was to (i) assess the long-term cost-effectiveness of acceptance and commitment therapy (ACT), a workplace dialog intervention (WDI), and ACT+WDI compared to treatment as usual (TAU) for common mental disorders and (ii ...
Anna Finnes, Jeffrey S Hoch, Pia Enebrink, JoAnne Dahl, Ata Ghaderi, Anna Nager, Inna Feldman   +6 more
doaj   +1 more source

Planning and acting [PDF]

Cognitive Science, 1978
A new theory of problem solving is presented, which embeds problem solving in the theory of action; in this theory, a problem is just a difficult action. Making this work requires a sophisticated language for‐talking about plans and their execution.
openaire   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Learning to Speak and Act in a Fantasy Text Adventure Game [PDF]

Conference on Empirical Methods in Natural Language Processing, 2019
We introduce a large-scale crowdsourced text adventure game as a research platform for studying grounded dialogue. In it, agents can perceive, emote, and act whilst conducting dialogue with other agents.
Jack Urbanek, Angela Fan, Siddharth Karamcheti, Saachi Jain, Samuel Humeau, Emily Dinan, Tim Rocktäschel, Douwe Kiela, Arthur Szlam, J. Weston   +9 more
semanticscholar   +1 more source

Relativismul lingvistic în proverbe

Limbaj si Context, 2009
The linguistic relativism appears as an attitude, a response to the language used to express a manner of thinking. People usually understand more than they say and can express.
Anca-Mariana Pegulescu
doaj   +1 more source

Psychoeducation Strategy: Acceptance and Commitment Therapy (ACT) to Improve Self-Efficacy of Stroke Patients

IJNP (Indonesian Journal of Nursing Practices), 2021
Background: Stroke is the most common cerebrovascular event. Stroke patients often have biological, spiritual, and psychosocial changes. Psychosocial problems experienced in stroke patients include problems with self-efficacy.
Tri Wahyuni Ismoyowati, Ratna Puspita Adiyasa   +1 more
doaj   +1 more source