Results 71 to 80 of about 2,373,177 (247)
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
MU'TEZİLE MEZHEBİNDE İNSANIN FİİLLERİ PROBLEMİ
Cumhuriyet Üniversitesi İlahiyat Fakültesi Dergisi, 2004 Mu'tezile'nin beş temel prensibinden birisi adalettir. Onların bu prensibine göre insan hürdür ve kendi fiilierini kendisi yapar. Allah insanlara bir eylemi yapıp yapmama gücü vermiştir.
Harndi GÜNDOGAR
doaj
THE ROLE OF NATIONAL PARLIAMENTS IN VERIFYING THE COMPLIANCE WITH THE PRINCIPLES OF PROPORTIONALITY AND SUBSIDIARITY [PDF]
Challenges of the Knowledge Society, 2018 The decision-making process of the European Union is a particularly complex one and its democratic legitimacy has almost always been a preoccupation for the citizens involved in European affairs, researchers, practitioners of Union law and, ultimately,
Dragoș – Adrian BANTAȘ
doaj
On the Institution of Public Hearing – An Analysis from the Theoretical Point of View and the Perspective of the State’s Political Practice (Fifth to Ninth Term of the Sejm of the Republic of Poland) [PDF]
Krytyka PrawaThe purpose of the study is to evaluate the public hearings’ role in law-making. The study addresses the problem of whether the institution of public hearing is an instrument that has a real impact on the law-making process.
Bogusław Przywora +1 more
doaj +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Inaction as a Legal Fact in Civil Law (on the Example of the Republic of Belarus)
Teisė, 2019 Unlike other legal sciences, the science of civil law did not produce any meaningful theory of inaction as a legal fact. The purpose of this article is to fill in this blank space. As a result of research, the author exposes certain features of the legal
Ana Šafalovič
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source