Results 121 to 130 of about 71,688 (285)

Obesity in Classic Congenital Adrenal Hyperplasia: Mechanisms, Complications and Management

Clinical Endocrinology, EarlyView.
ABSTRACT Classic congenital adrenal hyperplasia (CCAH) is an autosomal recessive genetic disorder primarily caused by 21‐hydroxylase deficiency. Although the survival rate of patients has significantly improved with glucocorticoid replacement therapy, long‐term use of supraphysiological doses and multiple factors inherent to the disease itself have led
Jialin Mu, Yue Li, Meng Sun, Yulin Li, Panpan Li, Hui Zou   +5 more
wiley   +1 more source

Challenges in Diagnosing Central Adrenal Insufficiency in Children: Cortisol‐Stimulating Tests are Safe and Often Required

Clinical Endocrinology, EarlyView.
ABSTRACT Introduction The accuracy and safety of cortisol‐stimulating tests (CSTs) for assessing hypothalamic–pituitary–adrenal (HPA) axis integrity, including the diagnosis of central adrenal insufficiency (CAI), in children remain uncertain. Although these tests can simultaneously evaluate cortisol and growth hormone secretion, the present study ...
Mariana Peduti Halah, Ana Carolina Maia Teodózio, Davi Casale Aragon, Paula Conde Lamparelli Elias, Margaret de Castro, Ayrton Custodio Moreira, Sonir Rauber Antonini   +6 more
wiley   +1 more source

Normal adrenocorticotropic hormone levels do not exclude adrenal insufficiency during immune checkpoint inhibitor therapy: evidence from clinical, steroid, and structural analyses

Frontiers in Endocrinology
IntroductionImmune checkpoint inhibitor-induced isolated adrenocorticotropic hormone (ACTH) deficiency (ICI-IAD) represents a critical endocrine immune-related adverse event (irAE) that may become life-threatening without timely diagnosis.
Yuria Ishibashi, Ryuta Baba, Akira Okada, Yu Otagaki, Takaya Kodama, Gentaro Egusa, Gaku Nagano, Tsuguka Matsuda, Ryoichi Miura, Atsushi Ono, Masataka Tsuge, Noboru Hattori, Haruya Ohno   +12 more
doaj   +1 more source

The hypothalamic-pituitary-adrenal axis and perinatal treatment of premature foals

, 2013
The danger and vulnerability associated with a preterm birth seem to be closely correlated with a dysfunction of the fetal hypothalamic-pituitary-adrenal (HPA) axis, whose maturation in the foal is without a doubt as delicate as it is important. Not only
Göransson, Lina
core  

Preclinical Cushing's syndrome in adrenal incidentalomas [PDF]

, 1992
Adrenal tumors are usually diagnosed by clinical symptoms of hormone excess. The increasing use of ultrasound and computed tomography results in the detection of a substantial number of incidentally discovered adrenal tumors.
Winkelmann, W., Saeger, W., Krestin, G. P., Nieke, J., Allolio, B., Reincke, Martin   +5 more
core  

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source

Utility of Adrenal Vein Sampling With and Without Ultra‐Low Dose ACTH Infusion in the Diagnostic Evaluation of Primary Aldosteronism

Endocrinology, Diabetes & Metabolism
Background Adrenal vein sampling (AVS), integral to identifying surgically remediable unilateral primary aldosteronism (PA), is technically challenging and subject to fluctuations in cortisol and aldosterone secretion.
Christopher A. Preston, Eric X. Z. Yong, Benjamin Marginson, Stephen G. Farrell, Matthew P. Sawyer, Hikaru Hashimura, Maresa M. Derbyshire, Richard J. MacIsaac, Nirupa Sachithanandan   +8 more
doaj   +1 more source

ACTH gel in the treatment of multiple sclerosis exacerbation: a case study

, 2015
Salvatore Napoli Neuro Institute of New England, Foxborough, MA, USA Abstract: Patients may refuse, be unable to use, or show nonresponse to conventional steroid treatment of multiple sclerosis (MS) exacerbation.
Napoli S
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Circulating Adrenocorticotropin (ACTH) as a Controlled Variable in the Regulation of ACTH Secretion

, 1971
Rats received 21 daily injections of hydrocortisone acetate, beginning 5 days after bilateral adrenalectomy. Immediately following cessation of hydrocortisone administration, adenohypo-physial adrenocorticotropin (ACTH) concentration was reduced to ...
R. G. Conrad, J. Kraicer
core   +1 more source

Clinical Implications and Research Progress of Salivary Biomarkers for Endocrine and Metabolic Disorders

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Similar to blood, saliva contains a broad range of biomarkers and may offer a non‐invasive, repeatable specimen for endocrine and metabolic assessment. This review aims to synthesise and evaluate recent advances in the clinical translation of salivary biomarkers, while providing a critical assessment of the diagnostic reliability and ...
Chuyan Yu, Jiaying Ni, Qian Dou, Hang Su, Ziyi Zhang, Xiaojing Ma, Qing Dai, Jian Zhou   +7 more
wiley   +1 more source