Results 121 to 130 of about 54,662 (205)
Abstract Clinically non‐functioning pituitary neuroendocrine tumors (NF‐PitNETs) lack effective medical therapies, and the role of somatostatin receptor ligands (SRLs) and dopamine agonists (DAs) in this setting is controversial. We evaluated the in vitro response of NF‐PitNETs to multiple SRL and/or DA treatments, focusing on the role of receptor ...
Claudia Campana +9 more
wiley +1 more source
Abstract Prolactinomas in the transition age present unique challenges; treatment strategies and long‐term outcomes in this population remain incompletely characterised. This is a multicentre, retrospective study of 110 consecutive patients (33 males) with prolactinomas, aged 15–25 years, across five Italian referral centres (2010–2025).
Dario De Alcubierre +17 more
wiley +1 more source
The Skin‐Lightening Efficacy and Mechanisms of Botanical Extracts: A Comprehensive Review
ABSTRACT Background Skin pigmentation is regulated by a complex network involving melanogenesis, melanosome transfer, oxidative stress, environmental stimuli, and epidermal turnover. Botanical extracts and phytochemicals have attracted increasing interest as potential skin‐lightening agents. This review evaluates their efficacy, mechanisms, and safety.
Siting Yang +6 more
wiley +1 more source
Case 24: A 42-Year-Old Woman With Fever and Shock. [PDF]
Bae S, Lee J, Ha J, Lim DJ, Lee J.
europepmc +1 more source
Liver cirrhosis is associated with altered glucocorticoid metabolism related to disease severity
Abstract Background Liver cirrhosis (LC) is frequently complicated by adrenal dysfunction; however, whether cirrhosis drives the coordinated, pathway‐specific reprogramming of cortisol metabolism remains unclear. Objectives We aimed to characterize axis‐specific alterations in cortisol metabolism in patients with LC, those with adrenal insufficiency ...
Soyeon Park +8 more
wiley +1 more source
Short Cationic ACTH-Related Peptides Can Modulate the Na<sub>V</sub>1.8 Channel Functioning, Resulting in an Analgesic Effect. [PDF]
Rogachevskii IV +13 more
europepmc +1 more source
ABSTRACT Sleep loss and low‐grade inflammation are common stressors that affect behaviour and recovery needs. To examine their separate and combined effects on motivation for everyday behaviours, we developed a two‐hit experimental model. Participants (N = 56, 31 women) completed three experimental visits: sleep saturation (two nights, 9 h in bed/night)
John Axelsson +6 more
wiley +1 more source
Prepubertal Screening for Testicular Adrenal Rest Tumors in Boys with Classic Congenital Adrenal Hyperplasia: Emerging Evidence and Practical Implications. [PDF]
Ranieri A +6 more
europepmc +1 more source
ABSTRACT Narcolepsy is classified as type 1 (NT1) or type 2 (NT2) mainly according to hypocretin deficiency rather than cataplexy. While CRH neuron loss in the PVN has been described in NT1, it remains unclear whether similar changes occur in narcolepsy without cataplexy.
Ling Shan +5 more
wiley +1 more source
A control theoretic primer for systems endocrinology. [PDF]
Boroujerdi M.
europepmc +1 more source

